DegronMD - Q6UXX5(ITIH6)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P926T	TCGA-22-4591	LUSC	TCGA	PSSTT	DEG_SPOP_SBC_1	914:918	Mutation rewiring degron network	0.1111
p.P926T	DO26620	LUSC	ICGC	PSSTT	DEG_SPOP_SBC_1	914:918	Mutation rewiring degron network	0.1111
p.V645L	TCGA-33-4587	LUSC	TCGA	PSSSS	DEG_SPOP_SBC_1	635:639	Mutation rewiring degron network	0.1667
p.V645L	DO27683	LUSC	ICGC	PSSSS	DEG_SPOP_SBC_1	635:639	Mutation rewiring degron network	0.1667
p.P781A	TCGA-34-8454	LUSC	TCGA	VTPLHS	DEG_SCF_FBW7_1	779:784	Mutation altering degron motif	0.7503
p.P781A	DO50094	LUSC	ICGC	VTPLHS	DEG_SCF_FBW7_1	779:784	Mutation altering degron motif	0.7503
p.S921Y	TCGA-50-5933	LUAD	TCGA	PSSTT	DEG_SPOP_SBC_1	914:918	Mutation rewiring degron network	0.25
p.S921Y	DO24800	LUAD	ICGC	PSSTT	DEG_SPOP_SBC_1	914:918	Mutation rewiring degron network	0.25
p.P905L	TCGA-64-5779	LUAD	TCGA	PSSTT	DEG_SPOP_SBC_1	914:918	Mutation rewiring degron network	0.0833
p.P905L	DO24930	LUAD	ICGC	PSSTT	DEG_SPOP_SBC_1	914:918	Mutation rewiring degron network	0.0833
p.G787C	TCGA-67-3774	LUAD	TCGA	VTPLHS	DEG_SCF_FBW7_1	779:784	Mutation rewiring degron network	0.25
p.G787C	DO24990	LUAD	ICGC	VTPLHS	DEG_SCF_FBW7_1	779:784	Mutation rewiring degron network	0.25
p.G787C	SIDM01103	Squamous Cell Lung Carcinoma	GDSC	VTPLHS	DEG_SCF_FBW7_1	779:784	Mutation rewiring degron network	0.25
p.G787C	ACH-000665	Lung Cancer	CCLE	VTPLHS	DEG_SCF_FBW7_1	779:784	Mutation rewiring degron network	0.25
p.G787C	SK-MES-1	lung	COSMIC	VTPLHS	DEG_SCF_FBW7_1	779:784	Mutation rewiring degron network	0.25
p.P905S	TCGA-86-8054	LUAD	TCGA	PSSTT	DEG_SPOP_SBC_1	914:918	Mutation rewiring degron network	0.0833
p.P905S	DO23923	LUAD	ICGC	PSSTT	DEG_SPOP_SBC_1	914:918	Mutation rewiring degron network	0.0833
p.S910R	TCGA-AA-3966	COAD	TCGA	PSSTT	DEG_SPOP_SBC_1	914:918	Mutation rewiring degron network	0.2222
p.S910R	DO10068	COAD	ICGC	PSSTT	DEG_SPOP_SBC_1	914:918	Mutation rewiring degron network	0.2222
p.S973A	TCGA-AJ-A3EK	UCEC	TCGA	PTPEGS	DEG_SCF_FBW7_1	975:980	Mutation rewiring degron network	0.2778
p.S973A	DO41584	UCEC	ICGC	PTPEGS	DEG_SCF_FBW7_1	975:980	Mutation rewiring degron network	0.2778
p.G642A	TCGA-AJ-A3EK	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	635:639	Mutation rewiring degron network	0.25
p.G642A	DO41584	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	635:639	Mutation rewiring degron network	0.25
p.K777N	TCGA-AN-A046	BRCA	TCGA	VTPLHS	DEG_SCF_FBW7_1	779:784	Mutation rewiring degron network	0.2778
p.K777N	DO1285	BRCA	ICGC	VTPLHS	DEG_SCF_FBW7_1	779:784	Mutation rewiring degron network	0.2778
p.G644V	TCGA-BF-A1PZ	SKCM	TCGA	PSSSS	DEG_SPOP_SBC_1	635:639	Mutation rewiring degron network	0.1944
p.G644V	DO50279	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	635:639	Mutation rewiring degron network	0.1944
p.H783Y	TCGA-BG-A222	UCEC	TCGA	VTPLHS	DEG_SCF_FBW7_1	779:784	Mutation altering degron motif	0.6118
p.H783Y	DO42977	UCEC	ICGC	VTPLHS	DEG_SCF_FBW7_1	779:784	Mutation altering degron motif	0.6118
p.P786S	TCGA-BS-A0UF	UCEC	TCGA	VTPLHS	DEG_SCF_FBW7_1	779:784	Mutation rewiring degron network	0.2778
p.P786S	DO41488	UCEC	ICGC	VTPLHS	DEG_SCF_FBW7_1	779:784	Mutation rewiring degron network	0.2778
p.T626N	TCGA-CR-6484	HNSC	TCGA	PSSSS	DEG_SPOP_SBC_1	635:639	Mutation rewiring degron network	0.0833
p.T626N	DO15206	HNSC	ICGC	PSSSS	DEG_SPOP_SBC_1	635:639	Mutation rewiring degron network	0.0833
p.S910G	TCGA-D7-A4Z0	STAD	TCGA	PSSTT	DEG_SPOP_SBC_1	914:918	Mutation rewiring degron network	0.2222
p.S910G	DO47765	STAD	ICGC	PSSTT	DEG_SPOP_SBC_1	914:918	Mutation rewiring degron network	0.2222
p.S973F	TCGA-DK-A3IS	BLCA	TCGA	PTPEGS	DEG_SCF_FBW7_1	975:980	Mutation rewiring degron network	0.2778
p.S973F	DO566	BLCA	ICGC	PTPEGS	DEG_SCF_FBW7_1	975:980	Mutation rewiring degron network	0.2778
p.I633V	TCGA-EO-A3B0	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	635:639	Mutation rewiring degron network	0.2778
p.I633V	DO219773	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	635:639	Mutation rewiring degron network	0.2778
p.P977S	TCGA-EY-A215	UCEC	TCGA	PTPEGS	DEG_SCF_FBW7_1	975:980	Mutation altering degron motif	0.6752
p.P977S	DO42665	UCEC	ICGC	PTPEGS	DEG_SCF_FBW7_1	975:980	Mutation altering degron motif	0.6752
p.I986M	TCGA-EY-A54A	UCEC	TCGA	PTPEGS	DEG_SCF_FBW7_1	975:980	Mutation rewiring degron network	0.1667
p.I986M	DO48175	UCEC	ICGC	PTPEGS	DEG_SCF_FBW7_1	975:980	Mutation rewiring degron network	0.1667
p.S627Y	TCGA-FI-A2D5	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	635:639	Mutation rewiring degron network	0.1111
p.S627Y	DO41331	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	635:639	Mutation rewiring degron network	0.1111
p.C778Y	TCGA-HT-8563	LGG	TCGA	VTPLHS	DEG_SCF_FBW7_1	779:784	Mutation rewiring degron network	0.3056
p.C778Y	DO44596	LGG	ICGC	VTPLHS	DEG_SCF_FBW7_1	779:784	Mutation rewiring degron network	0.3056
p.M967I	TCGA-IB-7651	PAAD	TCGA	PTPEGS	DEG_SCF_FBW7_1	975:980	Mutation rewiring degron network	0.1111
p.M967I	DO46657	PAAD	ICGC	PTPEGS	DEG_SCF_FBW7_1	975:980	Mutation rewiring degron network	0.1111
p.P914S	TCGA-W3-AA1V	SKCM	TCGA	PSSTT	DEG_SPOP_SBC_1	914:918	Mutation altering degron motif	0.6752
p.P914S	DO51276	SKCM	ICGC	PSSTT	DEG_SPOP_SBC_1	914:918	Mutation altering degron motif	0.6752
p.E925K	TCGA-XF-A8HB	BLCA	TCGA	PSSTT	DEG_SPOP_SBC_1	914:918	Mutation rewiring degron network	0.1389
p.E925K	DO51907	BLCA	ICGC	PSSTT	DEG_SPOP_SBC_1	914:918	Mutation rewiring degron network	0.1389
p.S636L	TCGA-Z2-A8RT	SKCM	TCGA	PSSSS	DEG_SPOP_SBC_1	635:639	Mutation altering degron motif	0.6556
p.S636L	DO51301	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	635:639	Mutation altering degron motif	0.6556
p.P771S	DO227943	BRCA	ICGC	VTPLHS	DEG_SCF_FBW7_1	779:784	Mutation rewiring degron network	0.1111
p.P28H	DO228948	LICA	ICGC	PASSS	DEG_SPOP_SBC_1	28:32	Mutation altering degron motif	0.7694
p.S770L	DO228965	LICA	ICGC	VTPLHS	DEG_SCF_FBW7_1	779:784	Mutation blocking phosphorylation signal	0.5278
p.T21K	DO229008	LICA	ICGC	PASSS	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.1389
p.P965L	DO23198	LINC	ICGC	PTPEGS	DEG_SCF_FBW7_1	975:980	Mutation rewiring degron network	0.0556
p.K777E	DO231326	THCA	ICGC	VTPLHS	DEG_SCF_FBW7_1	779:784	Mutation rewiring degron network	0.2778
p.T626I	SIDM02041	Colorectal Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	635:639	Mutation rewiring degron network	0.0833
p.A788V	SIDM02013	Colorectal Carcinoma	GDSC	VTPLHS	DEG_SCF_FBW7_1	779:784	Mutation rewiring degron network	0.2222
p.A788V	SIDM01133	Other Solid Cancers	GDSC	VTPLHS	DEG_SCF_FBW7_1	779:784	Mutation rewiring degron network	0.2222
p.A788V	ACH-002177	Lung Cancer	CCLE	VTPLHS	DEG_SCF_FBW7_1	779:784	Mutation rewiring degron network	0.2222
p.A788V	NCI-H835	lung	COSMIC	VTPLHS	DEG_SCF_FBW7_1	779:784	Mutation rewiring degron network	0.2222
p.I908L	SIDM00856	Other Solid Cancers	GDSC	PSSTT	DEG_SPOP_SBC_1	914:918	Mutation rewiring degron network	0.1667
p.I908L	SIDM01056	Breast Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	914:918	Mutation rewiring degron network	0.1667
p.Y22H	SIDM00475	Ovarian Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.1667
p.Y22H	ACH-000091	Ovarian Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.1667
p.Y22H	OV-56	ovary	COSMIC	PASSS	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.1667
p.I908V	SIDM00047	Non-Small Cell Lung Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	914:918	Mutation rewiring degron network	0.1667
p.I908V	EMC-BAC-2	lung	COSMIC	PSSTT	DEG_SPOP_SBC_1	914:918	Mutation rewiring degron network	0.1667
p.H641D	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	635:639	Mutation rewiring degron network	0.2778
p.H641D	ACH-002101	Lung Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	635:639	Mutation rewiring degron network	0.2778
p.H641D	EMC-BAC-1	lung	COSMIC	PSSSS	DEG_SPOP_SBC_1	635:639	Mutation rewiring degron network	0.2778
p.P771H	SIDM00740	Squamous Cell Lung Carcinoma	GDSC	VTPLHS	DEG_SCF_FBW7_1	779:784	Mutation rewiring degron network	0.1111
p.P771H	ACH-000747	Lung Cancer	CCLE	VTPLHS	DEG_SCF_FBW7_1	779:784	Mutation rewiring degron network	0.1111
p.P771H	NCI-H1703	lung	COSMIC	VTPLHS	DEG_SCF_FBW7_1	779:784	Mutation rewiring degron network	0.1111
p.K772N	SIDM00726	Non-Small Cell Lung Carcinoma	GDSC	VTPLHS	DEG_SCF_FBW7_1	779:784	Mutation substituting flanking lysine	0.25
p.K772N	ACH-000875	Lung Cancer	CCLE	VTPLHS	DEG_SCF_FBW7_1	779:784	Mutation substituting flanking lysine	0.25
p.K772N	NCI-H2347	lung	COSMIC	VTPLHS	DEG_SCF_FBW7_1	779:784	Mutation substituting flanking lysine	0.25
p.L794V	SIDM00959	Acute Myeloid Leukemia	GDSC	VTPLHS	DEG_SCF_FBW7_1	779:784	Mutation rewiring degron network	0.0556
p.L794V	ACH-000641	Leukemia	CCLE	VTPLHS	DEG_SCF_FBW7_1	779:784	Mutation rewiring degron network	0.0556
p.L794V	CMK	haematopoietic and lymphoid tissue	COSMIC	VTPLHS	DEG_SCF_FBW7_1	779:784	Mutation rewiring degron network	0.0556
p.S41C	ACH-000923	Lymphoma	CCLE	PASSS	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.0833
p.N983D	ACH-000982	Colon/Colorectal Cancer	CCLE	PTPEGS	DEG_SCF_FBW7_1	975:980	Mutation rewiring degron network	0.25
p.P905A	ACH-001522	Skin Cancer	CCLE	PSSTT	DEG_SPOP_SBC_1	914:918	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ITIH6

UniProt ID: Q6UXX5

Entrez ID: 347365

Protein name: Inter-alpha-trypsin inhibitor heavy chain H6 (Inter-alpha-trypsin inhibitor heavy chain H5-like protein) (Inter-alpha inhibitor H5-like protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ITIH6 in