DegronMD

Uniprot ID: Q6UXX5

Source protein: Inter-alpha-trypsin inhibitor heavy chain H6

Source gene: ITIH6

Class: DEG_SCF_FBW7_1

Location: 975:980

E3 ligase: FBXW7

DEGRON score: 0.8896

ASA_SCORE: 78.0667

COIL: 0.9143

CONS_SCORE: 0.1753

DSS_SCORE: 0.5731

HELIX: 0.0142

FCONS_SCORE: 0.9845

RIG_SCORE: 0.5472

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S973A	TCGA-AJ-A3EK	UCEC	TCGA	PTPEGS	DEG_SCF_FBW7_1	0.2778
p.S973A	DO41584	UCEC	ICGC	PTPEGS	DEG_SCF_FBW7_1	0.2778
p.S973F	TCGA-DK-A3IS	BLCA	TCGA	PTPEGS	DEG_SCF_FBW7_1	0.2778
p.S973F	DO566	BLCA	ICGC	PTPEGS	DEG_SCF_FBW7_1	0.2778
p.P977S	TCGA-EY-A215	UCEC	TCGA	PTPEGS	DEG_SCF_FBW7_1	0.6752
p.P977S	DO42665	UCEC	ICGC	PTPEGS	DEG_SCF_FBW7_1	0.6752
p.I986M	TCGA-EY-A54A	UCEC	TCGA	PTPEGS	DEG_SCF_FBW7_1	0.1667
p.I986M	DO48175	UCEC	ICGC	PTPEGS	DEG_SCF_FBW7_1	0.1667
p.M967I	TCGA-IB-7651	PAAD	TCGA	PTPEGS	DEG_SCF_FBW7_1	0.1111
p.M967I	DO46657	PAAD	ICGC	PTPEGS	DEG_SCF_FBW7_1	0.1111
p.P965L	DO23198	LINC	ICGC	PTPEGS	DEG_SCF_FBW7_1	0.0556
p.N983D	ACH-000982	Colon/Colorectal Cancer	CCLE	PTPEGS	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6UXX5	Inter-alpha-trypsin inhibitor heavy chain H6	DEG_SCF_FBW7_1	975:980	PTPEGS	FBXW7	0.8896	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons