DegronMD

Uniprot ID: Q6UXX5

Source protein: Inter-alpha-trypsin inhibitor heavy chain H6

Source gene: ITIH6

Class: DEG_SCF_FBW7_1

Location: 779:784

E3 ligase: FBXW7

DEGRON score: 0.9948

ASA_SCORE: 54.5833

COIL: 0.804

CONS_SCORE: 0.2355

DSS_SCORE: 0.6302

HELIX: 0.039

FCONS_SCORE: 0.8865

RIG_SCORE: 0.6873

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P781A	TCGA-34-8454	LUSC	TCGA	VTPLHS	DEG_SCF_FBW7_1	0.7503
p.P781A	DO50094	LUSC	ICGC	VTPLHS	DEG_SCF_FBW7_1	0.7503
p.G787C	TCGA-67-3774	LUAD	TCGA	VTPLHS	DEG_SCF_FBW7_1	0.25
p.G787C	DO24990	LUAD	ICGC	VTPLHS	DEG_SCF_FBW7_1	0.25
p.G787C	SIDM01103	Squamous Cell Lung Carcinoma	GDSC	VTPLHS	DEG_SCF_FBW7_1	0.25
p.G787C	ACH-000665	Lung Cancer	CCLE	VTPLHS	DEG_SCF_FBW7_1	0.25
p.G787C	SK-MES-1	lung	COSMIC	VTPLHS	DEG_SCF_FBW7_1	0.25
p.K777N	TCGA-AN-A046	BRCA	TCGA	VTPLHS	DEG_SCF_FBW7_1	0.2778
p.K777N	DO1285	BRCA	ICGC	VTPLHS	DEG_SCF_FBW7_1	0.2778
p.H783Y	TCGA-BG-A222	UCEC	TCGA	VTPLHS	DEG_SCF_FBW7_1	0.6118
p.H783Y	DO42977	UCEC	ICGC	VTPLHS	DEG_SCF_FBW7_1	0.6118
p.P786S	TCGA-BS-A0UF	UCEC	TCGA	VTPLHS	DEG_SCF_FBW7_1	0.2778
p.P786S	DO41488	UCEC	ICGC	VTPLHS	DEG_SCF_FBW7_1	0.2778
p.C778Y	TCGA-HT-8563	LGG	TCGA	VTPLHS	DEG_SCF_FBW7_1	0.3056
p.C778Y	DO44596	LGG	ICGC	VTPLHS	DEG_SCF_FBW7_1	0.3056
p.P771S	DO227943	BRCA	ICGC	VTPLHS	DEG_SCF_FBW7_1	0.1111
p.S770L	DO228965	LICA	ICGC	VTPLHS	DEG_SCF_FBW7_1	0.5278
p.K777E	DO231326	THCA	ICGC	VTPLHS	DEG_SCF_FBW7_1	0.2778
p.A788V	SIDM02013	Colorectal Carcinoma	GDSC	VTPLHS	DEG_SCF_FBW7_1	0.2222
p.A788V	SIDM01133	Other Solid Cancers	GDSC	VTPLHS	DEG_SCF_FBW7_1	0.2222
p.A788V	ACH-002177	Lung Cancer	CCLE	VTPLHS	DEG_SCF_FBW7_1	0.2222
p.A788V	NCI-H835	lung	COSMIC	VTPLHS	DEG_SCF_FBW7_1	0.2222
p.P771H	SIDM00740	Squamous Cell Lung Carcinoma	GDSC	VTPLHS	DEG_SCF_FBW7_1	0.1111
p.P771H	ACH-000747	Lung Cancer	CCLE	VTPLHS	DEG_SCF_FBW7_1	0.1111
p.P771H	NCI-H1703	lung	COSMIC	VTPLHS	DEG_SCF_FBW7_1	0.1111
p.K772N	SIDM00726	Non-Small Cell Lung Carcinoma	GDSC	VTPLHS	DEG_SCF_FBW7_1	0.25
p.K772N	ACH-000875	Lung Cancer	CCLE	VTPLHS	DEG_SCF_FBW7_1	0.25
p.K772N	NCI-H2347	lung	COSMIC	VTPLHS	DEG_SCF_FBW7_1	0.25
p.L794V	SIDM00959	Acute Myeloid Leukemia	GDSC	VTPLHS	DEG_SCF_FBW7_1	0.0556
p.L794V	ACH-000641	Leukemia	CCLE	VTPLHS	DEG_SCF_FBW7_1	0.0556
p.L794V	CMK	haematopoietic_and_lymphoid_tissue	COSMIC	VTPLHS	DEG_SCF_FBW7_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VTPLHS

Degron related mutations and impact score

Drug responses associated with ITIH6 mutations

All proteins holding degron of VTPLHS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6UXX5	Inter-alpha-trypsin inhibitor heavy chain H6	DEG_SCF_FBW7_1	779:784	VTPLHS	FBXW7	0.9948	More...