DegronMD

Uniprot ID: Q6VAB6

Source protein: Kinase suppressor of Ras 2

Source gene: KSR2

Class: DEG_SPOP_SBC_1

Location: 521:525

E3 ligase: SPOP

DEGRON score: 0.982

ASA_SCORE: 86.7

COIL: 0.9604

CONS_SCORE: 0.4211

DSS_SCORE: 0.7806

HELIX: 0.0262

FCONS_SCORE: 1.08

RIG_SCORE: 0.4369

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T524M	TCGA-A6-2686	COAD	TCGA	PSSTT	DEG_SPOP_SBC_1	0.7423
p.T524M	DO7828	COAD	ICGC	PSSTT	DEG_SPOP_SBC_1	0.7423
p.S531L	TCGA-D3-A51T	SKCM	TCGA	PSSTT	DEG_SPOP_SBC_1	0.1667
p.S531L	TCGA-EE-A3JD	SKCM	TCGA	PSSTT	DEG_SPOP_SBC_1	0.1667
p.P512R	TCGA-J4-AATZ	PRAD	TCGA	PSSTT	DEG_SPOP_SBC_1	0.0833
p.P513L	DO9708	COAD	ICGC	PSSTT	DEG_SPOP_SBC_1	0.1111
p.P529T	DO229045	LICA	ICGC	PSSTT	DEG_SPOP_SBC_1	0.2222
p.P521R	SIDM00870	Breast Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	0.7512
p.P521R	HCC202	breast	COSMIC	PSSTT	DEG_SPOP_SBC_1	0.7512
p.R525L	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	0.8428
p.T525A	ACH-000983	Leukemia	CCLE	PSSTT	DEG_SPOP_SBC_1	0.7139
p.T525A	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	PSSTT	DEG_SPOP_SBC_1	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14776	Transcription elongation regulator 1	DEG_SPOP_SBC_1	279:283	PSSTT	SPOP	0.9606	More...
O75626	PR domain zinc finger protein 1	DEG_SPOP_SBC_1	330:334	PSSTT	SPOP	0.9804	More...
P10323	Acrosin	DEG_SPOP_SBC_1	372:376	PSSTT	SPOP	0.9214	More...
P16070	CD44 antigen	DEG_SPOP_SBC_1	389:393	PSSTT	SPOP	0.912	More...
P19801	Amiloride-sensitive amine oxidase [copper-containing]	DEG_SPOP_SBC_1	58:62	PSSTT	SPOP	0.6653	More...
P27816	Microtubule-associated protein 4	DEG_SPOP_SBC_1	913:917	PSSTT	SPOP	0.9979	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1715:1719	PSSTT	SPOP	0.9877	More...
Q16186	Proteasomal ubiquitin receptor ADRM1	DEG_SPOP_SBC_1	218:222	PSSTT	SPOP	0.979	More...
Q6VAB6	Kinase suppressor of Ras 2	DEG_SPOP_SBC_1	521:525	PSSTT	SPOP	0.982	More...
Q8IVT5	Kinase suppressor of Ras 1	DEG_SPOP_SBC_1	448:452	PSSTT	SPOP	0.9811	More...
Q8IWE5	Pleckstrin homology domain-containing family M member 2	DEG_SPOP_SBC_1	379:383	PSSTT	SPOP	0.6967	More...
Q8IYB5	Stromal membrane-associated protein 1	DEG_SPOP_SBC_1	445:449	PSSTT	SPOP	0.9873	More...
Q8IZT6	Abnormal spindle-like microcephaly-associated protein	DEG_SPOP_SBC_1	564:568	PSSTT	SPOP	0.9996	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	2083:2087	PSSTT	SPOP	0.6521	More...
Q9BZ23	Pantothenate kinase 2, mitochondrial	DEG_SPOP_SBC_1	35:39	PSSTT	SPOP	0.9845	More...
Q9UBW5	Bridging integrator 2	DEG_SPOP_SBC_1	363:367	PSSTT	SPOP	0.9824	More...
Q6P4D5	PABIR family member 1	DEG_SPOP_SBC_1	14:18	PSSTT	SPOP	0.8064	More...
Q6UXX5	Inter-alpha-trypsin inhibitor heavy chain H6	DEG_SPOP_SBC_1	914:918	PSSTT	SPOP	0.5086	More...
Q9H1U4	Multiple epidermal growth factor-like domains protein 9	DEG_SPOP_SBC_1	111:115	PSSTT	SPOP	0.8482	More...
Q9UKJ0	Paired immunoglobulin-like type 2 receptor beta	DEG_SPOP_SBC_1	161:165	PSSTT	SPOP	0.9384	More...
Q9ULJ7	Ankyrin repeat domain-containing protein 50	DEG_SPOP_SBC_1	1235:1239	PSSTT	SPOP	0.9936	More...
Q9Y2D5	A-kinase anchor protein 2	DEG_SPOP_SBC_1	153:157	PSSTT	SPOP	0.9567	More...
Q2KHR3	Glutamine and serine-rich protein 1	DEG_SPOP_SBC_1	1195:1199	PSSTT	SPOP	0.9043	More...
Q76KD6	Speriolin	DEG_SPOP_SBC_1	351:355	PSSTT	SPOP	0.9888	More...
Q9HC44	Vasculin-like protein 1	DEG_SPOP_SBC_1	297:301	PSSTT	SPOP	0.9981	More...
Q9P2B7	Cilia- and flagella-associated protein 97	DEG_SPOP_SBC_1	234:238	PSSTT	SPOP	0.9913	More...
A6NM66	Uncharacterized protein encoded by LINC01548	DEG_SPOP_SBC_1	82:86	PSSTT	SPOP	0.6139	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PSSTT

Degron related mutations and impact score

Drug responses associated with KSR2 mutations

All proteins holding degron of PSSTT