DegronMD - Q8IYB5(SMAP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.W452S	TCGA-05-5425	LUAD	TCGA	PSSTT	DEG_SPOP_SBC_1	445:449	Mutation rewiring degron network	0.25
p.G451E	TCGA-34-A5IX	LUSC	TCGA	PSSTT	DEG_SPOP_SBC_1	445:449	Mutation rewiring degron network	0.2778
p.T439S	TCGA-AB-2833	LAML	TCGA	PSSTT	DEG_SPOP_SBC_1	445:449	Mutation rewiring degron network	0.1667
p.S457L	TCGA-BG-A222	UCEC	TCGA	PSSTT	DEG_SPOP_SBC_1	445:449	Mutation rewiring degron network	0.1111
p.L274R	TCGA-BR-8361	STAD	TCGA	LDLFTE	LIG_APCC_ABBA_1	282:287	Mutation rewiring degron network	0.1111
p.S279F	TCGA-BT-A20J	BLCA	TCGA	LDLFTE	LIG_APCC_ABBA_1	282:287	Mutation rewiring degron network	0.25
p.G458C	TCGA-CV-5432	HNSC	TCGA	PSSTT	DEG_SPOP_SBC_1	445:449	Mutation rewiring degron network	0.0833
p.A272E	TCGA-VS-A8QF	CESC	TCGA	LDLFTE	LIG_APCC_ABBA_1	282:287	Mutation rewiring degron network	0.0556
p.Y282H	DO51634	CESC	ICGC	LDLFTE	LIG_APCC_ABBA_1	282:287	Mutation altering degron motif	0.7229
p.K275T	DO234190	ESAD	ICGC	LDLFTE	LIG_APCC_ABBA_1	282:287	Mutation rewiring degron network	0.1389
p.G294V	DO26142	LUAD	ICGC	LDLFTE	LIG_APCC_ABBA_1	282:287	Mutation rewiring degron network	0.1389
p.Q289H	DO232224	PBCA	ICGC	LDLFTE	LIG_APCC_ABBA_1	282:287	Mutation rewiring degron network	0.2778
p.L273F	DO40847	UCEC	ICGC	LDLFTE	LIG_APCC_ABBA_1	282:287	Mutation rewiring degron network	0.0833
p.S280Y	DO43202	UCEC	ICGC	LDLFTE	LIG_APCC_ABBA_1	282:287	Mutation rewiring degron network	0.2778
p.S280F	DO41524	UCEC	ICGC	LDLFTE	LIG_APCC_ABBA_1	282:287	Mutation rewiring degron network	0.2778
p.T278S	SIDM00296	Small Cell Lung Carcinoma	GDSC	LDLFTE	LIG_APCC_ABBA_1	282:287	Mutation rewiring degron network	0.2222
p.T278S	ACH-002051	Lung Cancer	CCLE	LDLFTE	LIG_APCC_ABBA_1	282:287	Mutation rewiring degron network	0.2222
p.T278S	LU-134-A	lung	COSMIC	LDLFTE	LIG_APCC_ABBA_1	282:287	Mutation rewiring degron network	0.2222
p.P438T	SIDM00853	Other Sarcomas	GDSC	PSSTT	DEG_SPOP_SBC_1	445:449	Mutation rewiring degron network	0.1389
p.P438T	GCT	soft tissue	COSMIC	PSSTT	DEG_SPOP_SBC_1	445:449	Mutation rewiring degron network	0.1389
p.T289A	SIDM01608	Endometrial Carcinoma	GDSC	LDLFTE	LIG_APCC_ABBA_1	282:287	Mutation rewiring degron network	0.2778
p.T289A	ACH-000990	Endometrial/Uterine Cancer	CCLE	LDLFTE	LIG_APCC_ABBA_1	282:287	Mutation rewiring degron network	0.2778
p.T292I	NCI-H69	lung	COSMIC	LDLFTE	LIG_APCC_ABBA_1	282:287	Mutation rewiring degron network	0.1944

Kaplan plot for SMAP1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SMAP1

UniProt ID: Q8IYB5

Entrez ID: 60682

Protein name: Stromal membrane-associated protein 1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SMAP1 in