DegronMD

Uniprot ID: Q8IYB5

Source protein: Stromal membrane-associated protein 1

Source gene: SMAP1

Class: LIG_APCC_ABBA_1

Location: 282:287

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9367

ASA_SCORE: 80.4833

COIL: 0.6205

CONS_SCORE: 0.3618

DSS_SCORE: 0.4723

HELIX: 0.3495

FCONS_SCORE: 1.2521

RIG_SCORE: 0.8025

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L274R	TCGA-BR-8361	STAD	TCGA	LDLFTE	LIG_APCC_ABBA_1	0.1111
p.S279F	TCGA-BT-A20J	BLCA	TCGA	LDLFTE	LIG_APCC_ABBA_1	0.25
p.A272E	TCGA-VS-A8QF	CESC	TCGA	LDLFTE	LIG_APCC_ABBA_1	0.0556
p.Y282H	DO51634	CESC	ICGC	LDLFTE	LIG_APCC_ABBA_1	0.7229
p.K275T	DO234190	ESAD	ICGC	LDLFTE	LIG_APCC_ABBA_1	0.1389
p.G294V	DO26142	LUAD	ICGC	LDLFTE	LIG_APCC_ABBA_1	0.1389
p.Q289H	DO232224	PBCA	ICGC	LDLFTE	LIG_APCC_ABBA_1	0.2778
p.L273F	DO40847	UCEC	ICGC	LDLFTE	LIG_APCC_ABBA_1	0.0833
p.S280Y	DO43202	UCEC	ICGC	LDLFTE	LIG_APCC_ABBA_1	0.2778
p.S280F	DO41524	UCEC	ICGC	LDLFTE	LIG_APCC_ABBA_1	0.2778
p.T278S	SIDM00296	Small Cell Lung Carcinoma	GDSC	LDLFTE	LIG_APCC_ABBA_1	0.2222
p.T278S	ACH-002051	Lung Cancer	CCLE	LDLFTE	LIG_APCC_ABBA_1	0.2222
p.T278S	LU-134-A	lung	COSMIC	LDLFTE	LIG_APCC_ABBA_1	0.2222
p.T289A	SIDM01608	Endometrial Carcinoma	GDSC	LDLFTE	LIG_APCC_ABBA_1	0.2778
p.T289A	ACH-000990	Endometrial/Uterine Cancer	CCLE	LDLFTE	LIG_APCC_ABBA_1	0.2778
p.T292I	NCI-H69	lung	COSMIC	LDLFTE	LIG_APCC_ABBA_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IYB5	Stromal membrane-associated protein 1	LIG_APCC_ABBA_1	282:287	LDLFTE	APC,CDC20,FZR1	0.9367	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons