DegronMD - P27816(MAP4)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L530I	TCGA-19-5956	GBM	TCGA	VTPPPE	DEG_SCF_FBW7_2	520:525	Mutation rewiring degron network	0.1944
p.L530I	DO13863	GBM	ICGC	VTPPPE	DEG_SCF_FBW7_2	520:525	Mutation rewiring degron network	0.1944
p.L530I	SIDM01043	Other Sarcomas	GDSC	VTPPPE	DEG_SCF_FBW7_2	520:525	Mutation rewiring degron network	0.1944
p.L530I	ESS-1	endometrium	COSMIC	VTPPPE	DEG_SCF_FBW7_2	520:525	Mutation rewiring degron network	0.1944
p.V534I	TCGA-32-2616	GBM	TCGA	VTPPPE	DEG_SCF_FBW7_2	520:525	Mutation rewiring degron network	0.0833
p.V534I	DO13462	GBM	ICGC	VTPPPE	DEG_SCF_FBW7_2	520:525	Mutation rewiring degron network	0.0833
p.D519Y	TCGA-55-7576	LUAD	TCGA	VTPPPE	DEG_SCF_FBW7_2	520:525	Mutation rewiring degron network	0.3056
p.D519Y	DO24431	LUAD	ICGC	VTPPPE	DEG_SCF_FBW7_2	520:525	Mutation rewiring degron network	0.3056
p.K718R	TCGA-97-A4LX	LUAD	TCGA	AKTST	DEG_SPOP_SBC_1	710:714	Mutation substituting flanking lysine	0.3333
p.K718R	DO218934	LUAD	ICGC	AKTST	DEG_SPOP_SBC_1	710:714	Mutation substituting flanking lysine	0.3333
p.K377N	TCGA-AA-A010	COAD	TCGA	PKENK	DEG_APCC_KENBOX_2	373:377	Mutation altering degron motif	0.5806
p.A815V	TCGA-AB-2833	LAML	TCGA	AKTTT	DEG_SPOP_SBC_1	808:812	Mutation rewiring degron network	0.25
p.A815V	DO21679	LAML	ICGC	AKTTT	DEG_SPOP_SBC_1	808:812	Mutation rewiring degron network	0.25
p.D363G	TCGA-AP-A1DV	UCEC	TCGA	PKENK	DEG_APCC_KENBOX_2	373:377	Mutation rewiring degron network	0.0556
p.D363G	DO43186	UCEC	ICGC	PKENK	DEG_APCC_KENBOX_2	373:377	Mutation rewiring degron network	0.0556
p.E381D	TCGA-AX-A05Z	UCEC	TCGA	PKENK	DEG_APCC_KENBOX_2	373:377	Mutation rewiring degron network	0.2222
p.E381D	DO40884	UCEC	ICGC	PKENK	DEG_APCC_KENBOX_2	373:377	Mutation rewiring degron network	0.2222
p.S715L	TCGA-AX-A06F	UCEC	TCGA	AKTST	DEG_SPOP_SBC_1	710:714	Mutation rewiring degron network	0.3056
p.S715L	TCGA-EE-A2GC	SKCM	TCGA	AKTST	DEG_SPOP_SBC_1	710:714	Mutation rewiring degron network	0.3056
p.S715L	DO37839	SKCM	ICGC	AKTST	DEG_SPOP_SBC_1	710:714	Mutation rewiring degron network	0.3056
p.S715L	DO41752	UCEC	ICGC	AKTST	DEG_SPOP_SBC_1	710:714	Mutation rewiring degron network	0.3056
p.G883W	TCGA-AX-A2HA	UCEC	TCGA	APAAGVVPS	DEG_SIAH_1	879:887	Mutation altering degron motif	0.6714
p.G883W	DO42504	UCEC	ICGC	APAAGVVPS	DEG_SIAH_1	879:887	Mutation altering degron motif	0.6714
p.L920H	TCGA-BP-4985	KIRC	TCGA	PSSTT	DEG_SPOP_SBC_1	913:917	Mutation rewiring degron network	0.25
p.L920H	DO20693	KIRC	ICGC	PSSTT	DEG_SPOP_SBC_1	913:917	Mutation rewiring degron network	0.25
p.V411A	TCGA-BR-7707	STAD	TCGA	PKENK	DEG_APCC_KENBOX_2	399:403	Mutation rewiring degron network	0.1111
p.V411A	DO38487	STAD	ICGC	PKENK	DEG_APCC_KENBOX_2	399:403	Mutation rewiring degron network	0.1111
p.K532T	TCGA-CC-5262	LIHC	TCGA	VTPPPE	DEG_SCF_FBW7_2	520:525	Mutation substituting flanking lysine	0.25
p.K532T	DO22953	LIHC	ICGC	VTPPPE	DEG_SCF_FBW7_2	520:525	Mutation substituting flanking lysine	0.25
p.K802N	TCGA-CD-5800	STAD	TCGA	AKTTT	DEG_SPOP_SBC_1	808:812	Mutation substituting flanking lysine	0.2778
p.K802N	DO38431	STAD	ICGC	AKTTT	DEG_SPOP_SBC_1	808:812	Mutation substituting flanking lysine	0.2778
p.A879V	TCGA-CQ-7068	HNSC	TCGA	APAAGVVPS	DEG_SIAH_1	879:887	Mutation altering degron motif	0.5825
p.A879V	DO15551	HNSC	ICGC	APAAGVVPS	DEG_SIAH_1	879:887	Mutation altering degron motif	0.5825
p.M514I	TCGA-DA-A1I1	SKCM	TCGA	VTPPPE	DEG_SCF_FBW7_2	520:525	Mutation rewiring degron network	0.1667
p.M514I	DO37966	SKCM	ICGC	VTPPPE	DEG_SCF_FBW7_2	520:525	Mutation rewiring degron network	0.1667
p.Q708E	TCGA-EK-A2RJ	CESC	TCGA	AKTST	DEG_SPOP_SBC_1	710:714	Mutation rewiring degron network	0.2778
p.Q708E	DO49950	CESC	ICGC	AKTST	DEG_SPOP_SBC_1	710:714	Mutation rewiring degron network	0.2778
p.P902H	TCGA-EO-A22R	UCEC	TCGA	VKATPMPS	DEG_SCF_FBW7_1	889:896	Mutation rewiring degron network	0.1667
p.P902H	DO42713	UCEC	ICGC	VKATPMPS	DEG_SCF_FBW7_1	889:896	Mutation rewiring degron network	0.1667
p.P366H	TCGA-EO-A22R	UCEC	TCGA	PKENK	DEG_APCC_KENBOX_2	373:377	Mutation rewiring degron network	0.1389
p.P366H	DO42713	UCEC	ICGC	PKENK	DEG_APCC_KENBOX_2	373:377	Mutation rewiring degron network	0.1389
p.I386V	TCGA-GV-A3QG	BLCA	TCGA	PKENK	DEG_APCC_KENBOX_2	373:377	Mutation rewiring degron network	0.0833
p.I386V	DO627	BLCA	ICGC	PKENK	DEG_APCC_KENBOX_2	373:377	Mutation rewiring degron network	0.0833
p.I386V	SIDM01590	Breast Carcinoma	GDSC	PKENK	DEG_APCC_KENBOX_2	373:377	Mutation rewiring degron network	0.0833
p.R860H	TCGA-IB-7651	PAAD	TCGA	PKSTS	DEG_SPOP_SBC_1	861:865	Mutation rewiring degron network	0.3056
p.R860H	DO46657	PAAD	ICGC	PKSTS	DEG_SPOP_SBC_1	861:865	Mutation rewiring degron network	0.3056
p.R860H	SIDM00889	Cervical Carcinoma	GDSC	PKSTS	DEG_SPOP_SBC_1	861:865	Mutation rewiring degron network	0.3056
p.R860H	C-33-A	cervix	COSMIC	PKSTS	DEG_SPOP_SBC_1	861:865	Mutation rewiring degron network	0.3056
p.R897W	TCGA-RP-A694	SKCM	TCGA	VKATPMPS	DEG_SCF_FBW7_1	889:896	Mutation rewiring degron network	0.3056
p.R897W	TCGA-RP-A694	SKCM	TCGA	APAAGVVPS	DEG_SIAH_1	879:887	Mutation rewiring degron network	0.0556
p.R897W	DO51269	SKCM	ICGC	VKATPMPS	DEG_SCF_FBW7_1	889:896	Mutation rewiring degron network	0.3056
p.R897W	DO51269	SKCM	ICGC	APAAGVVPS	DEG_SIAH_1	879:887	Mutation rewiring degron network	0.0556
p.P524L	DO1094	BRCA	ICGC	VTPPPE	DEG_SCF_FBW7_2	520:525	Mutation altering degron motif	0.6471
p.H925N	DO229389	BTCA	ICGC	PSSTT	DEG_SPOP_SBC_1	913:917	Mutation blocking phosphorylation signal	0.5556
p.K399E	DO8264	COAD	ICGC	PKENK	DEG_APCC_KENBOX_2	399:403	Mutation altering degron motif	0.7022
p.S405N	DO228935	COCA	ICGC	PKENK	DEG_APCC_KENBOX_2	399:403	Mutation rewiring degron network	0.2778
p.L853V	DO227709	COCA	ICGC	PKSTS	DEG_SPOP_SBC_1	861:865	Mutation blocking phosphorylation signal	0.5556
p.L853V	DO229010	COCA	ICGC	PKSTS	DEG_SPOP_SBC_1	861:865	Mutation blocking phosphorylation signal	0.5556
p.L853V	DO234205	ESAD	ICGC	PKSTS	DEG_SPOP_SBC_1	861:865	Mutation blocking phosphorylation signal	0.5556
p.L853V	DO228947	LICA	ICGC	PKSTS	DEG_SPOP_SBC_1	861:865	Mutation blocking phosphorylation signal	0.5556
p.K387Q	DO50346	ESAD	ICGC	PKENK	DEG_APCC_KENBOX_2	373:377	Mutation blocking ubiquitination signal	0.5
p.R705C	DO234168	ESAD	ICGC	AKTST	DEG_SPOP_SBC_1	710:714	Mutation rewiring degron network	0.1944
p.A817P	DO234285	ESAD	ICGC	AKTTT	DEG_SPOP_SBC_1	808:812	Mutation rewiring degron network	0.1944
p.A817P	SIDM00704	Small Cell Lung Carcinoma	GDSC	AKTTT	DEG_SPOP_SBC_1	808:812	Mutation rewiring degron network	0.1944
p.D905E	DO228952	LICA	ICGC	VKATPMPS	DEG_SCF_FBW7_1	889:896	Mutation rewiring degron network	0.0833
p.D905E	DO228952	LICA	ICGC	PSSTT	DEG_SPOP_SBC_1	913:917	Mutation rewiring degron network	0.1111
p.D369E	DO228952	LICA	ICGC	PKENK	DEG_APCC_KENBOX_2	373:377	Mutation rewiring degron network	0.2222
p.P805T	DO228974	LICA	ICGC	AKTTT	DEG_SPOP_SBC_1	808:812	Mutation rewiring degron network	0.25
p.A851E	DO228971	LICA	ICGC	PKSTS	DEG_SPOP_SBC_1	861:865	Mutation rewiring degron network	0.0556
p.D809E	DO229019	LICA	ICGC	AKTTT	DEG_SPOP_SBC_1	808:812	Mutation altering degron motif	0.6758
p.N533K	DO229029	LICA	ICGC	VTPPPE	DEG_SCF_FBW7_2	520:525	Mutation rewiring degron network	0.1111
p.P372T	DO229028	LICA	ICGC	PKENK	DEG_APCC_KENBOX_2	373:377	Mutation rewiring degron network	0.3056
p.P855Q	DO229032	LICA	ICGC	PKSTS	DEG_SPOP_SBC_1	861:865	Mutation rewiring degron network	0.1667
p.Q906K	DO229034	LICA	ICGC	VKATPMPS	DEG_SCF_FBW7_1	889:896	Mutation substituting flanking lysine	0.1667
p.Q906K	DO229034	LICA	ICGC	PSSTT	DEG_SPOP_SBC_1	913:917	Mutation substituting flanking lysine	0.25
p.S801Y	DO229036	LICA	ICGC	AKTTT	DEG_SPOP_SBC_1	808:812	Mutation rewiring degron network	0.1389
p.P522Q	DO229038	LICA	ICGC	VTPPPE	DEG_SCF_FBW7_2	520:525	Mutation altering degron motif	0.7035
p.P814T	DO229041	LICA	ICGC	AKTTT	DEG_SPOP_SBC_1	808:812	Mutation rewiring degron network	0.2778
p.P712T	DO229045	LICA	ICGC	AKTST	DEG_SPOP_SBC_1	710:714	Mutation altering degron motif	0.7031
p.P902T	DO50913	LICA	ICGC	VKATPMPS	DEG_SCF_FBW7_1	889:896	Mutation rewiring degron network	0.1667
p.S867G	DO45049	LINC	ICGC	PKSTS	DEG_SPOP_SBC_1	861:865	Mutation rewiring degron network	0.2778
p.E851K	DO23533	LIRI	ICGC	PKSTS	DEG_SPOP_SBC_1	861:865	Mutation rewiring degron network	0.0556
p.P902S	DO222908	MELA	ICGC	VKATPMPS	DEG_SCF_FBW7_1	889:896	Mutation rewiring degron network	0.1667
p.A802D	DO232224	PBCA	ICGC	AKTTT	DEG_SPOP_SBC_1	808:812	Mutation substituting flanking lysine	0.2778
p.K910N	DO36556	READ	ICGC	PSSTT	DEG_SPOP_SBC_1	913:917	Mutation rewiring degron network	0.25
p.K910N	DO36881	READ	ICGC	PSSTT	DEG_SPOP_SBC_1	913:917	Mutation rewiring degron network	0.25
p.E391G	DO220124	SARC	ICGC	PKENK	DEG_APCC_KENBOX_2	399:403	Mutation rewiring degron network	0.1111
p.A401T	DO38192	STAD	ICGC	PKENK	DEG_APCC_KENBOX_2	399:403	Mutation altering degron motif	0.7139
p.N907S	DO42023	UCEC	ICGC	PSSTT	DEG_SPOP_SBC_1	913:917	Mutation substituting flanking lysine	0.2778
p.S888Y	DO43154	UCEC	ICGC	VKATPMPS	DEG_SCF_FBW7_1	889:896	Mutation rewiring degron network	0.3056
p.S888Y	DO43154	UCEC	ICGC	APAAGVVPS	DEG_SIAH_1	879:887	Mutation rewiring degron network	0.3056
p.P874T	DO42608	UCEC	ICGC	APAAGVVPS	DEG_SIAH_1	879:887	Mutation blocking phosphorylation signal	0.6389
p.P874T	DO42608	UCEC	ICGC	PKSTS	DEG_SPOP_SBC_1	861:865	Mutation blocking phosphorylation signal	0.5278
p.T526A	SIDM01174	Cervical Carcinoma	GDSC	VTPPPE	DEG_SCF_FBW7_2	520:525	Mutation blocking phosphorylation signal	0.75
p.T526A	SIDM00803	Kidney Carcinoma	GDSC	VTPPPE	DEG_SCF_FBW7_2	520:525	Mutation blocking phosphorylation signal	0.75
p.T526A	SIDM00210	Ovarian Carcinoma	GDSC	VTPPPE	DEG_SCF_FBW7_2	520:525	Mutation blocking phosphorylation signal	0.75
p.T526A	SIDM00666	Glioma	GDSC	VTPPPE	DEG_SCF_FBW7_2	520:525	Mutation blocking phosphorylation signal	0.75
p.T526A	SIDM01089	B-Cell Non-Hodgkin's Lymphoma	GDSC	VTPPPE	DEG_SCF_FBW7_2	520:525	Mutation blocking phosphorylation signal	0.75
p.T526A	SIDM01757	Bladder Carcinoma	GDSC	VTPPPE	DEG_SCF_FBW7_2	520:525	Mutation blocking phosphorylation signal	0.75
p.T526A	SIDM01491	Colorectal Carcinoma	GDSC	VTPPPE	DEG_SCF_FBW7_2	520:525	Mutation blocking phosphorylation signal	0.75
p.S393F	SIDM00007	Other Solid Cancers	GDSC	PKENK	DEG_APCC_KENBOX_2	399:403	Mutation blocking phosphorylation signal	0.6111
p.S393F	MCC13	skin	COSMIC	PKENK	DEG_APCC_KENBOX_2	399:403	Mutation blocking phosphorylation signal	0.6111
p.P385L	SIDM01060	Melanoma	GDSC	PKENK	DEG_APCC_KENBOX_2	373:377	Mutation rewiring degron network	0.1111
p.P385L	IGR-1	skin	COSMIC	PKENK	DEG_APCC_KENBOX_2	373:377	Mutation rewiring degron network	0.1111
p.P902L	SIDM00931	Thyroid Gland Carcinoma	GDSC	VKATPMPS	DEG_SCF_FBW7_1	889:896	Mutation rewiring degron network	0.1667
p.P902L	CAL-62	thyroid	COSMIC	VKATPMPS	DEG_SCF_FBW7_1	889:896	Mutation rewiring degron network	0.1667
p.A891T	SIDM00081	Melanoma	GDSC	VKATPMPS	DEG_SCF_FBW7_1	889:896	Mutation altering degron motif	0.6028
p.A891T	SIDM01746	Osteosarcoma	GDSC	VKATPMPS	DEG_SCF_FBW7_1	889:896	Mutation altering degron motif	0.6028
p.A891T	SIDM01775	B-Cell Non-Hodgkin's Lymphoma	GDSC	VKATPMPS	DEG_SCF_FBW7_1	889:896	Mutation altering degron motif	0.6028
p.C535G	SIDM01190	Bladder Carcinoma	GDSC	VTPPPE	DEG_SCF_FBW7_2	520:525	Mutation rewiring degron network	0.0556
p.C535G	TCCSUP	urinary tract	COSMIC	VTPPPE	DEG_SCF_FBW7_2	520:525	Mutation rewiring degron network	0.0556
p.A808V	SIDM00732	Glioblastoma	GDSC	AKTTT	DEG_SPOP_SBC_1	808:812	Mutation altering degron motif	0.5825
p.A808V	D-263MG	central nervous system	COSMIC	AKTTT	DEG_SPOP_SBC_1	808:812	Mutation altering degron motif	0.5825
p.S803G	SIDM00816	Kidney Carcinoma	GDSC	AKTTT	DEG_SPOP_SBC_1	808:812	Mutation blocking phosphorylation signal	0.6389
p.S803G	RCC-MF	kidney	COSMIC	AKTTT	DEG_SPOP_SBC_1	808:812	Mutation blocking phosphorylation signal	0.6389
p.T706A	SIDM00451	T-Lymphoblastic Leukemia	GDSC	AKTST	DEG_SPOP_SBC_1	710:714	Mutation blocking phosphorylation signal	0.6667
p.T706A	PF-382	haematopoietic and lymphoid tissue	COSMIC	AKTST	DEG_SPOP_SBC_1	710:714	Mutation blocking phosphorylation signal	0.6667
p.S910L	SIDM01398	Melanoma	GDSC	PSSTT	DEG_SPOP_SBC_1	913:917	Mutation rewiring degron network	0.25
p.P511S	ACH-000547	Bladder Cancer	CCLE	VTPPPE	DEG_SCF_FBW7_2	520:525	Mutation rewiring degron network	0.0833
p.P511S	HT-1197	urinary tract	COSMIC	VTPPPE	DEG_SCF_FBW7_2	520:525	Mutation rewiring degron network	0.0833
p.P402L	ACH-000882	Skin Cancer	CCLE	PKENK	DEG_APCC_KENBOX_2	399:403	Mutation altering degron motif	0.7582
p.P402L	IGR-1	skin	COSMIC	PKENK	DEG_APCC_KENBOX_2	399:403	Mutation altering degron motif	0.7582
p.S890F	ACH-000961	Endometrial/Uterine Cancer	CCLE	VKATPMPS	DEG_SCF_FBW7_1	889:896	Mutation altering degron motif	0.7982
p.A811V	ACH-001484	Leukemia	CCLE	AKTTT	DEG_SPOP_SBC_1	808:812	Mutation altering degron motif	0.6936
p.A811V	ACH-001485	Leukemia	CCLE	AKTTT	DEG_SPOP_SBC_1	808:812	Mutation altering degron motif	0.6936
p.A802V	ACH-001515	Cervical Cancer	CCLE	AKTTT	DEG_SPOP_SBC_1	808:812	Mutation substituting flanking lysine	0.2778
p.D909N	ACH-001526	Bone Cancer	CCLE	PSSTT	DEG_SPOP_SBC_1	913:917	Mutation blocking phosphorylation signal	0.6667
p.S410F	ACH-001550	Skin Cancer	CCLE	PKENK	DEG_APCC_KENBOX_2	399:403	Mutation rewiring degron network	0.1389
p.S410F	MCC13	skin	COSMIC	PKENK	DEG_APCC_KENBOX_2	399:403	Mutation rewiring degron network	0.1389
p.G714R	EoL-1-cell	haematopoietic and lymphoid tissue	COSMIC	AKTST	DEG_SPOP_SBC_1	710:714	Mutation altering degron motif	0.7568
p.L875V	201T	lung	COSMIC	APAAGVVPS	DEG_SIAH_1	879:887	Mutation rewiring degron network	0.2222
p.L875V	201T	lung	COSMIC	PKSTS	DEG_SPOP_SBC_1	861:865	Mutation rewiring degron network	0.0556
p.P807Q	JEKO-1	haematopoietic and lymphoid tissue	COSMIC	AKTTT	DEG_SPOP_SBC_1	808:812	Mutation rewiring degron network	0.3056
p.T872P	OCI-LY-19	haematopoietic and lymphoid tissue	COSMIC	APAAGVVPS	DEG_SIAH_1	879:887	Mutation blocking phosphorylation signal	0.5833
p.T872P	OCI-LY-19	haematopoietic and lymphoid tissue	COSMIC	PKSTS	DEG_SPOP_SBC_1	861:865	Mutation blocking phosphorylation signal	0.5833
p.P511L	EFO-27	ovary	COSMIC	VTPPPE	DEG_SCF_FBW7_2	520:525	Mutation rewiring degron network	0.0833
p.E521Q	NCI-H2342	lung	COSMIC	VTPPPE	DEG_SCF_FBW7_2	520:525	Mutation altering degron motif	0.6744

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MAP4

UniProt ID: P27816

Entrez ID: 4134

Protein name: Microtubule-associated protein 4 (MAP-4)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for MAP4 in