DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
PKENK
Uniprot ID:
P27816
Source protein:
Microtubule-associated protein 4
Source gene:
MAP4
Class:
DEG_APCC_KENBOX_2
Location:
373:377
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.8238
ASA_SCORE:
119.14
COIL:
0.8444
CONS_SCORE:
0.1137
DSS_SCORE:
0.776
HELIX:
0.1334
FCONS_SCORE:
0.2364
RIG_SCORE:
0.5824
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.K377N
TCGA-AA-A010
COAD
TCGA
PKENK
DEG_APCC_KENBOX_2
0.5806
p.D363G
TCGA-AP-A1DV
UCEC
TCGA
PKENK
DEG_APCC_KENBOX_2
0.0556
p.D363G
DO43186
UCEC
ICGC
PKENK
DEG_APCC_KENBOX_2
0.0556
p.E381D
TCGA-AX-A05Z
UCEC
TCGA
PKENK
DEG_APCC_KENBOX_2
0.2222
p.E381D
DO40884
UCEC
ICGC
PKENK
DEG_APCC_KENBOX_2
0.2222
p.P366H
TCGA-EO-A22R
UCEC
TCGA
PKENK
DEG_APCC_KENBOX_2
0.1389
p.P366H
DO42713
UCEC
ICGC
PKENK
DEG_APCC_KENBOX_2
0.1389
p.I386V
TCGA-GV-A3QG
BLCA
TCGA
PKENK
DEG_APCC_KENBOX_2
0.0833
p.I386V
DO627
BLCA
ICGC
PKENK
DEG_APCC_KENBOX_2
0.0833
p.I386V
SIDM01590
Breast Carcinoma
GDSC
PKENK
DEG_APCC_KENBOX_2
0.0833
p.K387Q
DO50346
ESAD
ICGC
PKENK
DEG_APCC_KENBOX_2
0.5
p.D369E
DO228952
LICA
ICGC
PKENK
DEG_APCC_KENBOX_2
0.2222
p.P372T
DO229028
LICA
ICGC
PKENK
DEG_APCC_KENBOX_2
0.3056
p.P385L
SIDM01060
Melanoma
GDSC
PKENK
DEG_APCC_KENBOX_2
0.1111
p.P385L
IGR-1
skin
COSMIC
PKENK
DEG_APCC_KENBOX_2
0.1111
Drug responses associated with MAP4 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PKENK
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O43379
WD repeat-containing protein 62
DEG_APCC_KENBOX_2
98:102
PKENK
APC,CDC20,FZR1
0.5471
More...
P13521
Secretogranin-2
DEG_APCC_KENBOX_2
129:133
PKENK
APC,CDC20,FZR1
0.5373
More...
P14902
Indoleamine 2,3-dioxygenase 1
DEG_APCC_KENBOX_2
362:366
PKENK
APC,CDC20,FZR1
0.5041
More...
P27816
Microtubule-associated protein 4
DEG_APCC_KENBOX_2
373:377
PKENK
APC,CDC20,FZR1
0.8238
More...
P27816
Microtubule-associated protein 4
DEG_APCC_KENBOX_2
399:403
PKENK
APC,CDC20,FZR1
0.689
More...
P42568
Protein AF-9
DEG_APCC_KENBOX_2
236:240
PKENK
APC,CDC20,FZR1
0.9558
More...
Q5H9J7
Protein BEX5
DEG_APCC_KENBOX_2
5:9
PKENK
APC,CDC20,FZR1
0.6674
More...
Q8WWQ0
PH-interacting protein
DEG_APCC_KENBOX_2
763:767
PKENK
APC,CDC20,FZR1
0.8724
More...
Q96S96
Phosphatidylethanolamine-binding protein 4
DEG_APCC_KENBOX_2
166:170
PKENK
APC,CDC20,FZR1
0.761
More...
Q8IZ63
Proline-rich protein 22
DEG_APCC_KENBOX_2
188:192
PKENK
APC,CDC20,FZR1
0.9074
More...