DegronMD

Uniprot ID: P42568

Source protein: Protein AF-9

Source gene: MLLT3

Class: DEG_APCC_KENBOX_2

Location: 236:240

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9558

ASA_SCORE: 122.06

COIL: 0.9418

CONS_SCORE: 0.5196

DSS_SCORE: 0.7028

HELIX: 0.0372

FCONS_SCORE: 1.0344

RIG_SCORE: 0.5608

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V248I	TCGA-50-5049	LUAD	TCGA	PKENK	DEG_APCC_KENBOX_2	0.1111
p.V248I	SIDM00068	Colorectal Carcinoma	GDSC	PKENK	DEG_APCC_KENBOX_2	0.1111
p.V248I	ACH-002394	Colon/Colorectal Cancer	CCLE	PKENK	DEG_APCC_KENBOX_2	0.1111
p.V248I	GEO	large_intestine	COSMIC	PKENK	DEG_APCC_KENBOX_2	0.1111
p.N226K	TCGA-63-A5MS	LUSC	TCGA	PKENK	DEG_APCC_KENBOX_2	0.0556
p.E231Q	TCGA-BL-A3JM	BLCA	TCGA	PKENK	DEG_APCC_KENBOX_2	0.1944
p.K240E	TCGA-DB-A64Q	LGG	TCGA	PKENK	DEG_APCC_KENBOX_2	0.591
p.E245D	TCGA-FJ-A3Z7	BLCA	TCGA	PKENK	DEG_APCC_KENBOX_2	0.1944
p.E245D	DO463	BLCA	ICGC	PKENK	DEG_APCC_KENBOX_2	0.1944
p.S233F	TCGA-GN-A8LK	SKCM	TCGA	PKENK	DEG_APCC_KENBOX_2	0.25
p.S233F	DO222837	MELA	ICGC	PKENK	DEG_APCC_KENBOX_2	0.25
p.S233F	DO51259	SKCM	ICGC	PKENK	DEG_APCC_KENBOX_2	0.25
p.E228Q	DO532	BLCA	ICGC	PKENK	DEG_APCC_KENBOX_2	0.1111
p.V245I	DO23705	LUAD	ICGC	PKENK	DEG_APCC_KENBOX_2	0.1944
p.V245I	GEO	large_intestine	COSMIC	PKENK	DEG_APCC_KENBOX_2	0.1944
p.E231D	SIDM00845	Burkitt's Lymphoma	GDSC	PKENK	DEG_APCC_KENBOX_2	0.1944
p.E231D	SIDM00461	Acute Myeloid Leukemia	GDSC	PKENK	DEG_APCC_KENBOX_2	0.1944
p.E231D	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PKENK	DEG_APCC_KENBOX_2	0.1944
p.E231D	SIDM01519	Head and Neck Carcinoma	GDSC	PKENK	DEG_APCC_KENBOX_2	0.1944
p.E231D	ACH-000786	Lymphoma	CCLE	PKENK	DEG_APCC_KENBOX_2	0.1944
p.E231D	ACH-000992	Head and Neck Cancer	CCLE	PKENK	DEG_APCC_KENBOX_2	0.1944
p.E231D	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	PKENK	DEG_APCC_KENBOX_2	0.1944
p.E231D	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PKENK	DEG_APCC_KENBOX_2	0.1944
p.E231D	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	PKENK	DEG_APCC_KENBOX_2	0.1944
p.E238Q	SIDM00262	Ewing's Sarcoma	GDSC	PKENK	DEG_APCC_KENBOX_2	0.6744
p.E238Q	ACH-002107	Bone Cancer	CCLE	PKENK	DEG_APCC_KENBOX_2	0.6744
p.E238Q	ES6	bone	COSMIC	PKENK	DEG_APCC_KENBOX_2	0.6744
p.E235Q	ES6	bone	COSMIC	PKENK	DEG_APCC_KENBOX_2	0.3056
p.E228D	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	PKENK	DEG_APCC_KENBOX_2	0.1111
p.E228D	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PKENK	DEG_APCC_KENBOX_2	0.1111
p.E228D	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	PKENK	DEG_APCC_KENBOX_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43379	WD repeat-containing protein 62	DEG_APCC_KENBOX_2	98:102	PKENK	APC,CDC20,FZR1	0.5471	More...
P13521	Secretogranin-2	DEG_APCC_KENBOX_2	129:133	PKENK	APC,CDC20,FZR1	0.5373	More...
P14902	Indoleamine 2,3-dioxygenase 1	DEG_APCC_KENBOX_2	362:366	PKENK	APC,CDC20,FZR1	0.5041	More...
P27816	Microtubule-associated protein 4	DEG_APCC_KENBOX_2	373:377	PKENK	APC,CDC20,FZR1	0.8238	More...
P27816	Microtubule-associated protein 4	DEG_APCC_KENBOX_2	399:403	PKENK	APC,CDC20,FZR1	0.689	More...
P42568	Protein AF-9	DEG_APCC_KENBOX_2	236:240	PKENK	APC,CDC20,FZR1	0.9558	More...
Q5H9J7	Protein BEX5	DEG_APCC_KENBOX_2	5:9	PKENK	APC,CDC20,FZR1	0.6674	More...
Q8WWQ0	PH-interacting protein	DEG_APCC_KENBOX_2	763:767	PKENK	APC,CDC20,FZR1	0.8724	More...
Q96S96	Phosphatidylethanolamine-binding protein 4	DEG_APCC_KENBOX_2	166:170	PKENK	APC,CDC20,FZR1	0.761	More...
Q8IZ63	Proline-rich protein 22	DEG_APCC_KENBOX_2	188:192	PKENK	APC,CDC20,FZR1	0.9074	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PKENK

Degron related mutations and impact score

Drug responses associated with MLLT3 mutations

All proteins holding degron of PKENK