DegronMD

Uniprot ID: Q8WWQ0

Source protein: PH-interacting protein

Source gene: PHIP

Class: DEG_APCC_KENBOX_2

Location: 763:767

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8724

ASA_SCORE: 125.8

COIL: 0.8504

CONS_SCORE: 0.2823

DSS_SCORE: 0.6189

HELIX: 0.1186

FCONS_SCORE: 0.9624

RIG_SCORE: 0.678

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V771A	TCGA-20-1685	OV	TCGA	PKENK	DEG_APCC_KENBOX_2	0.2222
p.V771A	DO29688	OV	ICGC	PKENK	DEG_APCC_KENBOX_2	0.2222
p.K767N	TCGA-AX-A05Z	UCEC	TCGA	PKENK	DEG_APCC_KENBOX_2	0.5806
p.K767N	DO40884	UCEC	ICGC	PKENK	DEG_APCC_KENBOX_2	0.5806
p.H775Y	TCGA-B5-A3FC	UCEC	TCGA	PKENK	DEG_APCC_KENBOX_2	0.1111
p.H775Y	DO41871	UCEC	ICGC	PKENK	DEG_APCC_KENBOX_2	0.1111
p.A776T	TCGA-BH-A18G	BRCA	TCGA	PKENK	DEG_APCC_KENBOX_2	0.0833
p.A776T	DO3686	BRCA	ICGC	PKENK	DEG_APCC_KENBOX_2	0.0833
p.K773E	TCGA-DU-6392	LGG	TCGA	PKENK	DEG_APCC_KENBOX_2	0.6111
p.K773E	DO22237	LGG	ICGC	PKENK	DEG_APCC_KENBOX_2	0.6111
p.P769H	SIDM00660	Colorectal Carcinoma	GDSC	PKENK	DEG_APCC_KENBOX_2	0.2778
p.P769H	ACH-000985	Colon/Colorectal Cancer	CCLE	PKENK	DEG_APCC_KENBOX_2	0.2778
p.P769H	LS-411N	large_intestine	COSMIC	PKENK	DEG_APCC_KENBOX_2	0.2778
p.I768V	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	PKENK	DEG_APCC_KENBOX_2	0.3056
p.I768V	ACH-000916	Lung Cancer	CCLE	PKENK	DEG_APCC_KENBOX_2	0.3056
p.I768V	NCI-H1573	lung	COSMIC	PKENK	DEG_APCC_KENBOX_2	0.3056
p.K758T	ACH-001991	Primary	CCLE	PKENK	DEG_APCC_KENBOX_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43379	WD repeat-containing protein 62	DEG_APCC_KENBOX_2	98:102	PKENK	APC,CDC20,FZR1	0.5471	More...
P13521	Secretogranin-2	DEG_APCC_KENBOX_2	129:133	PKENK	APC,CDC20,FZR1	0.5373	More...
P14902	Indoleamine 2,3-dioxygenase 1	DEG_APCC_KENBOX_2	362:366	PKENK	APC,CDC20,FZR1	0.5041	More...
P27816	Microtubule-associated protein 4	DEG_APCC_KENBOX_2	373:377	PKENK	APC,CDC20,FZR1	0.8238	More...
P27816	Microtubule-associated protein 4	DEG_APCC_KENBOX_2	399:403	PKENK	APC,CDC20,FZR1	0.689	More...
P42568	Protein AF-9	DEG_APCC_KENBOX_2	236:240	PKENK	APC,CDC20,FZR1	0.9558	More...
Q5H9J7	Protein BEX5	DEG_APCC_KENBOX_2	5:9	PKENK	APC,CDC20,FZR1	0.6674	More...
Q8WWQ0	PH-interacting protein	DEG_APCC_KENBOX_2	763:767	PKENK	APC,CDC20,FZR1	0.8724	More...
Q96S96	Phosphatidylethanolamine-binding protein 4	DEG_APCC_KENBOX_2	166:170	PKENK	APC,CDC20,FZR1	0.761	More...
Q8IZ63	Proline-rich protein 22	DEG_APCC_KENBOX_2	188:192	PKENK	APC,CDC20,FZR1	0.9074	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons