DegronMD - P14902(IDO1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E369D	TCGA-AD-6889	COAD	TCGA	PKENK	DEG_APCC_KENBOX_2	362:366	Mutation rewiring degron network	0.25
p.E369D	DO8463	COAD	ICGC	PKENK	DEG_APCC_KENBOX_2	362:366	Mutation rewiring degron network	0.25
p.I356T	TCGA-D3-A2JF	SKCM	TCGA	PKENK	DEG_APCC_KENBOX_2	362:366	Mutation rewiring degron network	0.1667
p.I356T	DO38153	SKCM	ICGC	PKENK	DEG_APCC_KENBOX_2	362:366	Mutation rewiring degron network	0.1667
p.P371S	TCGA-D3-A8GM	SKCM	TCGA	PKENK	DEG_APCC_KENBOX_2	362:366	Mutation rewiring degron network	0.1944
p.P371S	DO50288	SKCM	ICGC	PKENK	DEG_APCC_KENBOX_2	362:366	Mutation rewiring degron network	0.1944
p.S372L	TCGA-DA-A95Z	SKCM	TCGA	PKENK	DEG_APCC_KENBOX_2	362:366	Mutation blocking phosphorylation signal	0.6111
p.S372L	DO219481	SKCM	ICGC	PKENK	DEG_APCC_KENBOX_2	362:366	Mutation blocking phosphorylation signal	0.6111
p.E364K	TCGA-EB-A3Y7	SKCM	TCGA	PKENK	DEG_APCC_KENBOX_2	362:366	Mutation altering degron motif	0.7022
p.E364K	DO37499	SKCM	ICGC	PKENK	DEG_APCC_KENBOX_2	362:366	Mutation altering degron motif	0.7022
p.S359G	DO10859	ESAD	ICGC	PKENK	DEG_APCC_KENBOX_2	362:366	Mutation rewiring degron network	0.25
p.S359I	DO228976	LICA	ICGC	PKENK	DEG_APCC_KENBOX_2	362:366	Mutation rewiring degron network	0.25
p.N365S	SIDM00568	Gastric Carcinoma	GDSC	PKENK	DEG_APCC_KENBOX_2	362:366	Mutation altering degron motif	0.7069
p.N365S	SIDM00817	Kidney Carcinoma	GDSC	PKENK	DEG_APCC_KENBOX_2	362:366	Mutation altering degron motif	0.7069
p.N365S	OCUM-1	stomach	COSMIC	PKENK	DEG_APCC_KENBOX_2	362:366	Mutation altering degron motif	0.7069
p.P362L	SIDM00006	Other Solid Cancers	GDSC	PKENK	DEG_APCC_KENBOX_2	362:366	Mutation altering degron motif	0.6471
p.P362L	ACH-001552	Skin Cancer	CCLE	PKENK	DEG_APCC_KENBOX_2	362:366	Mutation altering degron motif	0.6471
p.P362L	MCC26	skin	COSMIC	PKENK	DEG_APCC_KENBOX_2	362:366	Mutation altering degron motif	0.6471
p.K352N	SIDM00861	Ovarian Carcinoma	GDSC	PKENK	DEG_APCC_KENBOX_2	362:366	Mutation substituting flanking lysine	0.1667
p.K352N	ES-2	ovary	COSMIC	PKENK	DEG_APCC_KENBOX_2	362:366	Mutation substituting flanking lysine	0.1667

Kaplan plot for IDO1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

IDO1

UniProt ID: P14902

Entrez ID: 3620

Protein name: Indoleamine 2,3-dioxygenase 1 (IDO-1) (EC 1.13.11.52) (Indoleamine-pyrrole 2,3-dioxygenase)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for IDO1 in