DegronMD

Uniprot ID: P14902

Source protein: Indoleamine 2,3-dioxygenase 1

Source gene: IDO1

Class: DEG_APCC_KENBOX_2

Location: 362:366

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5041

ASA_SCORE: 108.02

COIL: 0.8374

CONS_SCORE: 0.3731

DSS_SCORE: 0.5759

HELIX: 0.1348

FCONS_SCORE: 0.7021

RIG_SCORE: 0.6553

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E369D	TCGA-AD-6889	COAD	TCGA	PKENK	DEG_APCC_KENBOX_2	0.25
p.E369D	DO8463	COAD	ICGC	PKENK	DEG_APCC_KENBOX_2	0.25
p.I356T	TCGA-D3-A2JF	SKCM	TCGA	PKENK	DEG_APCC_KENBOX_2	0.1667
p.I356T	DO38153	SKCM	ICGC	PKENK	DEG_APCC_KENBOX_2	0.1667
p.P371S	TCGA-D3-A8GM	SKCM	TCGA	PKENK	DEG_APCC_KENBOX_2	0.1944
p.P371S	DO50288	SKCM	ICGC	PKENK	DEG_APCC_KENBOX_2	0.1944
p.S372L	TCGA-DA-A95Z	SKCM	TCGA	PKENK	DEG_APCC_KENBOX_2	0.6111
p.S372L	DO219481	SKCM	ICGC	PKENK	DEG_APCC_KENBOX_2	0.6111
p.E364K	TCGA-EB-A3Y7	SKCM	TCGA	PKENK	DEG_APCC_KENBOX_2	0.7022
p.E364K	DO37499	SKCM	ICGC	PKENK	DEG_APCC_KENBOX_2	0.7022
p.S359G	DO10859	ESAD	ICGC	PKENK	DEG_APCC_KENBOX_2	0.25
p.S359I	DO228976	LICA	ICGC	PKENK	DEG_APCC_KENBOX_2	0.25
p.N365S	SIDM00568	Gastric Carcinoma	GDSC	PKENK	DEG_APCC_KENBOX_2	0.7069
p.N365S	SIDM00817	Kidney Carcinoma	GDSC	PKENK	DEG_APCC_KENBOX_2	0.7069
p.N365S	OCUM-1	stomach	COSMIC	PKENK	DEG_APCC_KENBOX_2	0.7069
p.P362L	SIDM00006	Other Solid Cancers	GDSC	PKENK	DEG_APCC_KENBOX_2	0.6471
p.P362L	ACH-001552	Skin Cancer	CCLE	PKENK	DEG_APCC_KENBOX_2	0.6471
p.P362L	MCC26	skin	COSMIC	PKENK	DEG_APCC_KENBOX_2	0.6471
p.K352N	SIDM00861	Ovarian Carcinoma	GDSC	PKENK	DEG_APCC_KENBOX_2	0.1667
p.K352N	ES-2	ovary	COSMIC	PKENK	DEG_APCC_KENBOX_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43379	WD repeat-containing protein 62	DEG_APCC_KENBOX_2	98:102	PKENK	APC,CDC20,FZR1	0.5471	More...
P13521	Secretogranin-2	DEG_APCC_KENBOX_2	129:133	PKENK	APC,CDC20,FZR1	0.5373	More...
P14902	Indoleamine 2,3-dioxygenase 1	DEG_APCC_KENBOX_2	362:366	PKENK	APC,CDC20,FZR1	0.5041	More...
P27816	Microtubule-associated protein 4	DEG_APCC_KENBOX_2	373:377	PKENK	APC,CDC20,FZR1	0.8238	More...
P27816	Microtubule-associated protein 4	DEG_APCC_KENBOX_2	399:403	PKENK	APC,CDC20,FZR1	0.689	More...
P42568	Protein AF-9	DEG_APCC_KENBOX_2	236:240	PKENK	APC,CDC20,FZR1	0.9558	More...
Q5H9J7	Protein BEX5	DEG_APCC_KENBOX_2	5:9	PKENK	APC,CDC20,FZR1	0.6674	More...
Q8WWQ0	PH-interacting protein	DEG_APCC_KENBOX_2	763:767	PKENK	APC,CDC20,FZR1	0.8724	More...
Q96S96	Phosphatidylethanolamine-binding protein 4	DEG_APCC_KENBOX_2	166:170	PKENK	APC,CDC20,FZR1	0.761	More...
Q8IZ63	Proline-rich protein 22	DEG_APCC_KENBOX_2	188:192	PKENK	APC,CDC20,FZR1	0.9074	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons