DegronMD - P42568(MLLT3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S385C	TCGA-06-1802	GBM	TCGA	PASSS	DEG_SPOP_SBC_1	381:385	Mutation altering degron motif	0.8652
p.S385C	DO12100	GBM	ICGC	PASSS	DEG_SPOP_SBC_1	381:385	Mutation altering degron motif	0.8652
p.D365H	TCGA-39-5016	LUSC	TCGA	LPPFDD	LIG_APCC_ABBA_1	352:357	Mutation rewiring degron network	0.1111
p.D365H	DO26701	LUSC	ICGC	LPPFDD	LIG_APCC_ABBA_1	352:357	Mutation rewiring degron network	0.1111
p.V248I	TCGA-50-5049	LUAD	TCGA	PKENK	DEG_APCC_KENBOX_2	236:240	Mutation rewiring degron network	0.1111
p.V248I	SIDM00068	Colorectal Carcinoma	GDSC	PKENK	DEG_APCC_KENBOX_2	236:240	Mutation rewiring degron network	0.1111
p.V248I	ACH-002394	Colon/Colorectal Cancer	CCLE	PKENK	DEG_APCC_KENBOX_2	236:240	Mutation rewiring degron network	0.1111
p.V248I	GEO	large intestine	COSMIC	PKENK	DEG_APCC_KENBOX_2	236:240	Mutation rewiring degron network	0.1111
p.N226K	TCGA-63-A5MS	LUSC	TCGA	PKENK	DEG_APCC_KENBOX_2	236:240	Mutation rewiring degron network	0.0556
p.P394A	TCGA-91-6836	LUAD	TCGA	PASSS	DEG_SPOP_SBC_1	381:385	Mutation rewiring degron network	0.0833
p.P394A	DO23854	LUAD	ICGC	PASSS	DEG_SPOP_SBC_1	381:385	Mutation rewiring degron network	0.0833
p.T351M	TCGA-AX-A1CE	UCEC	TCGA	LPPFDD	LIG_APCC_ABBA_1	352:357	Mutation rewiring degron network	0.3056
p.T351M	TCGA-BG-A18B	UCEC	TCGA	LPPFDD	LIG_APCC_ABBA_1	352:357	Mutation rewiring degron network	0.3056
p.T351M	SIDM00958	Chronic Myelogenous Leukemia	GDSC	LPPFDD	LIG_APCC_ABBA_1	352:357	Mutation rewiring degron network	0.3056
p.T351M	CML-T1	haematopoietic and lymphoid tissue	COSMIC	LPPFDD	LIG_APCC_ABBA_1	352:357	Mutation rewiring degron network	0.3056
p.E231Q	TCGA-BL-A3JM	BLCA	TCGA	PKENK	DEG_APCC_KENBOX_2	236:240	Mutation rewiring degron network	0.1944
p.P361T	TCGA-CG-5730	STAD	TCGA	LPPFDD	LIG_APCC_ABBA_1	352:357	Mutation rewiring degron network	0.2222
p.P361T	DO38324	STAD	ICGC	LPPFDD	LIG_APCC_ABBA_1	352:357	Mutation rewiring degron network	0.2222
p.K240E	TCGA-DB-A64Q	LGG	TCGA	PKENK	DEG_APCC_KENBOX_2	236:240	Mutation altering degron motif	0.591
p.E245D	TCGA-FJ-A3Z7	BLCA	TCGA	PKENK	DEG_APCC_KENBOX_2	236:240	Mutation rewiring degron network	0.1944
p.E245D	DO463	BLCA	ICGC	PKENK	DEG_APCC_KENBOX_2	236:240	Mutation rewiring degron network	0.1944
p.S233F	TCGA-GN-A8LK	SKCM	TCGA	PKENK	DEG_APCC_KENBOX_2	236:240	Mutation rewiring degron network	0.25
p.S233F	DO222837	MELA	ICGC	PKENK	DEG_APCC_KENBOX_2	236:240	Mutation rewiring degron network	0.25
p.S233F	DO51259	SKCM	ICGC	PKENK	DEG_APCC_KENBOX_2	236:240	Mutation rewiring degron network	0.25
p.D375N	TCGA-LN-A4A9	ESCA	TCGA	PASSS	DEG_SPOP_SBC_1	381:385	Mutation rewiring degron network	0.1667
p.T351R	TCGA-WE-AAA0	SKCM	TCGA	LPPFDD	LIG_APCC_ABBA_1	352:357	Mutation rewiring degron network	0.3056
p.T351R	DO51294	SKCM	ICGC	LPPFDD	LIG_APCC_ABBA_1	352:357	Mutation rewiring degron network	0.3056
p.E228Q	DO532	BLCA	ICGC	PKENK	DEG_APCC_KENBOX_2	236:240	Mutation rewiring degron network	0.1111
p.S389I	DO6685	CLLE	ICGC	PASSS	DEG_SPOP_SBC_1	381:385	Mutation rewiring degron network	0.2222
p.P381H	DO233652	GACA	ICGC	PASSS	DEG_SPOP_SBC_1	381:385	Mutation altering degron motif	0.7694
p.P381H	DO229037	LICA	ICGC	PASSS	DEG_SPOP_SBC_1	381:385	Mutation altering degron motif	0.7694
p.A382D	DO228948	LICA	ICGC	PASSS	DEG_SPOP_SBC_1	381:385	Mutation altering degron motif	0.6682
p.S391R	DO229026	LICA	ICGC	PASSS	DEG_SPOP_SBC_1	381:385	Mutation rewiring degron network	0.1667
p.T344A	DO50949	LICA	ICGC	LPPFDD	LIG_APCC_ABBA_1	352:357	Mutation rewiring degron network	0.1111
p.V245I	DO23705	LUAD	ICGC	PKENK	DEG_APCC_KENBOX_2	236:240	Mutation rewiring degron network	0.1944
p.V245I	GEO	large intestine	COSMIC	PKENK	DEG_APCC_KENBOX_2	236:240	Mutation rewiring degron network	0.1944
p.E231D	SIDM00845	Burkitt's Lymphoma	GDSC	PKENK	DEG_APCC_KENBOX_2	236:240	Mutation rewiring degron network	0.1944
p.E231D	SIDM00461	Acute Myeloid Leukemia	GDSC	PKENK	DEG_APCC_KENBOX_2	236:240	Mutation rewiring degron network	0.1944
p.E231D	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PKENK	DEG_APCC_KENBOX_2	236:240	Mutation rewiring degron network	0.1944
p.E231D	SIDM01519	Head and Neck Carcinoma	GDSC	PKENK	DEG_APCC_KENBOX_2	236:240	Mutation rewiring degron network	0.1944
p.E231D	ACH-000786	Lymphoma	CCLE	PKENK	DEG_APCC_KENBOX_2	236:240	Mutation rewiring degron network	0.1944
p.E231D	ACH-000992	Head and Neck Cancer	CCLE	PKENK	DEG_APCC_KENBOX_2	236:240	Mutation rewiring degron network	0.1944
p.E231D	DND-41	haematopoietic and lymphoid tissue	COSMIC	PKENK	DEG_APCC_KENBOX_2	236:240	Mutation rewiring degron network	0.1944
p.E231D	Daudi	haematopoietic and lymphoid tissue	COSMIC	PKENK	DEG_APCC_KENBOX_2	236:240	Mutation rewiring degron network	0.1944
p.E231D	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	PKENK	DEG_APCC_KENBOX_2	236:240	Mutation rewiring degron network	0.1944
p.S371F	SIDM01175	Other Sarcomas	GDSC	PASSS	DEG_SPOP_SBC_1	381:385	Mutation rewiring degron network	0.0556
p.S371F	ACH-002309	Sarcoma	CCLE	PASSS	DEG_SPOP_SBC_1	381:385	Mutation rewiring degron network	0.0556
p.S371F	SW684	soft tissue	COSMIC	PASSS	DEG_SPOP_SBC_1	381:385	Mutation rewiring degron network	0.0556
p.E238Q	SIDM00262	Ewing's Sarcoma	GDSC	PKENK	DEG_APCC_KENBOX_2	236:240	Mutation altering degron motif	0.6744
p.E238Q	ACH-002107	Bone Cancer	CCLE	PKENK	DEG_APCC_KENBOX_2	236:240	Mutation altering degron motif	0.6744
p.E238Q	ES6	bone	COSMIC	PKENK	DEG_APCC_KENBOX_2	236:240	Mutation altering degron motif	0.6744
p.P381S	SIDM00118	Colorectal Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	381:385	Mutation altering degron motif	0.6752
p.P381S	ACH-001081	Colon/Colorectal Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	381:385	Mutation altering degron motif	0.6752
p.P381S	HCC2998	large intestine	COSMIC	PASSS	DEG_SPOP_SBC_1	381:385	Mutation altering degron motif	0.6752
p.D357V	SIDM01667	B-Cell Non-Hodgkin's Lymphoma	GDSC	LPPFDD	LIG_APCC_ABBA_1	352:357	Mutation altering degron motif	0.7785
p.D357V	ACH-000220	Lymphoma	CCLE	LPPFDD	LIG_APCC_ABBA_1	352:357	Mutation altering degron motif	0.7785
p.E235Q	ES6	bone	COSMIC	PKENK	DEG_APCC_KENBOX_2	236:240	Mutation rewiring degron network	0.3056
p.E228D	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	PKENK	DEG_APCC_KENBOX_2	236:240	Mutation rewiring degron network	0.1111
p.E228D	Daudi	haematopoietic and lymphoid tissue	COSMIC	PKENK	DEG_APCC_KENBOX_2	236:240	Mutation rewiring degron network	0.1111
p.E228D	DND-41	haematopoietic and lymphoid tissue	COSMIC	PKENK	DEG_APCC_KENBOX_2	236:240	Mutation rewiring degron network	0.1111
p.T348M	CML-T1	haematopoietic and lymphoid tissue	COSMIC	LPPFDD	LIG_APCC_ABBA_1	352:357	Mutation substituting flanking lysine	0.3333
p.P378S	HCC2998	large intestine	COSMIC	PASSS	DEG_SPOP_SBC_1	381:385	Mutation rewiring degron network	0.25

Kaplan plot for MLLT3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MLLT3

UniProt ID: P42568

Entrez ID: 4300

Protein name: Protein AF-9 (ALL1-fused gene from chromosome 9 protein) (Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein) (YEATS domain-containing protein 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MLLT3 in