DegronMD

Uniprot ID: P42568

Source protein: Protein AF-9

Source gene: MLLT3

Class: LIG_APCC_ABBA_1

Location: 352:357

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7817

ASA_SCORE: 88.8

COIL: 0.7822

CONS_SCORE: 0.4689

DSS_SCORE: 0.6638

HELIX: 0.208

FCONS_SCORE: 0.9799

RIG_SCORE: 0.7011

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D365H	TCGA-39-5016	LUSC	TCGA	LPPFDD	LIG_APCC_ABBA_1	0.1111
p.D365H	DO26701	LUSC	ICGC	LPPFDD	LIG_APCC_ABBA_1	0.1111
p.T351M	TCGA-AX-A1CE	UCEC	TCGA	LPPFDD	LIG_APCC_ABBA_1	0.3056
p.T351M	TCGA-BG-A18B	UCEC	TCGA	LPPFDD	LIG_APCC_ABBA_1	0.3056
p.T351M	SIDM00958	Chronic Myelogenous Leukemia	GDSC	LPPFDD	LIG_APCC_ABBA_1	0.3056
p.T351M	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	LPPFDD	LIG_APCC_ABBA_1	0.3056
p.P361T	TCGA-CG-5730	STAD	TCGA	LPPFDD	LIG_APCC_ABBA_1	0.2222
p.P361T	DO38324	STAD	ICGC	LPPFDD	LIG_APCC_ABBA_1	0.2222
p.T351R	TCGA-WE-AAA0	SKCM	TCGA	LPPFDD	LIG_APCC_ABBA_1	0.3056
p.T351R	DO51294	SKCM	ICGC	LPPFDD	LIG_APCC_ABBA_1	0.3056
p.T344A	DO50949	LICA	ICGC	LPPFDD	LIG_APCC_ABBA_1	0.1111
p.D357V	SIDM01667	B-Cell Non-Hodgkin's Lymphoma	GDSC	LPPFDD	LIG_APCC_ABBA_1	0.7785
p.D357V	ACH-000220	Lymphoma	CCLE	LPPFDD	LIG_APCC_ABBA_1	0.7785
p.T348M	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	LPPFDD	LIG_APCC_ABBA_1	0.3333

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P42568	Protein AF-9	LIG_APCC_ABBA_1	352:357	LPPFDD	APC,CDC20,FZR1	0.7817	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons