DegronMD

Uniprot ID: Q8IZ63

Source protein: Proline-rich protein 22

Source gene: PRR22

Class: DEG_APCC_KENBOX_2

Location: 188:192

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9074

ASA_SCORE: 123.8

COIL: 0.9168

CONS_SCORE: 0.8214

DSS_SCORE: 0.6723

HELIX: 0.0478

FCONS_SCORE: 1.1912

RIG_SCORE: 0.5269

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P185L	TCGA-EB-A6R0	SKCM	TCGA	PKENK	DEG_APCC_KENBOX_2	0.25
p.P185L	DO48646	SKCM	ICGC	PKENK	DEG_APCC_KENBOX_2	0.25
p.P188H	DO50958	LICA	ICGC	PKENK	DEG_APCC_KENBOX_2	0.6583
p.P193L	DO224596	PACA	ICGC	PKENK	DEG_APCC_KENBOX_2	0.3056
p.P187H	DO229257	THCA	ICGC	PKENK	DEG_APCC_KENBOX_2	0.3056
p.A202V	DO229216	THCA	ICGC	PKENK	DEG_APCC_KENBOX_2	0.0556
p.P184S	DO229227	THCA	ICGC	PKENK	DEG_APCC_KENBOX_2	0.2222
p.P188A	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	PKENK	DEG_APCC_KENBOX_2	0.6392
p.P188A	SIDM00808	Burkitt's Lymphoma	GDSC	PKENK	DEG_APCC_KENBOX_2	0.6392
p.P188A	SIDM01254	Burkitt's Lymphoma	GDSC	PKENK	DEG_APCC_KENBOX_2	0.6392
p.A202E	SIDM00490	Glioma	GDSC	PKENK	DEG_APCC_KENBOX_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43379	WD repeat-containing protein 62	DEG_APCC_KENBOX_2	98:102	PKENK	APC,CDC20,FZR1	0.5471	More...
P13521	Secretogranin-2	DEG_APCC_KENBOX_2	129:133	PKENK	APC,CDC20,FZR1	0.5373	More...
P14902	Indoleamine 2,3-dioxygenase 1	DEG_APCC_KENBOX_2	362:366	PKENK	APC,CDC20,FZR1	0.5041	More...
P27816	Microtubule-associated protein 4	DEG_APCC_KENBOX_2	373:377	PKENK	APC,CDC20,FZR1	0.8238	More...
P27816	Microtubule-associated protein 4	DEG_APCC_KENBOX_2	399:403	PKENK	APC,CDC20,FZR1	0.689	More...
P42568	Protein AF-9	DEG_APCC_KENBOX_2	236:240	PKENK	APC,CDC20,FZR1	0.9558	More...
Q5H9J7	Protein BEX5	DEG_APCC_KENBOX_2	5:9	PKENK	APC,CDC20,FZR1	0.6674	More...
Q8WWQ0	PH-interacting protein	DEG_APCC_KENBOX_2	763:767	PKENK	APC,CDC20,FZR1	0.8724	More...
Q96S96	Phosphatidylethanolamine-binding protein 4	DEG_APCC_KENBOX_2	166:170	PKENK	APC,CDC20,FZR1	0.761	More...
Q8IZ63	Proline-rich protein 22	DEG_APCC_KENBOX_2	188:192	PKENK	APC,CDC20,FZR1	0.9074	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons