DegronMD

Uniprot ID: Q96S96

Source protein: Phosphatidylethanolamine-binding protein 4

Source gene: PEBP4

Class: DEG_APCC_KENBOX_2

Location: 166:170

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.761

ASA_SCORE: 113.74

COIL: 0.8636

CONS_SCORE: 0.4184

DSS_SCORE: 0.3292

HELIX: 0.0938

FCONS_SCORE: 0.951

RIG_SCORE: 0.7786

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M177I	TCGA-05-4396	LUAD	TCGA	PKENK	DEG_APCC_KENBOX_2	0.1389
p.M177I	TCGA-EE-A183	SKCM	TCGA	PKENK	DEG_APCC_KENBOX_2	0.1389
p.M177I	DO23838	LUAD	ICGC	PKENK	DEG_APCC_KENBOX_2	0.1389
p.M177I	DO37715	SKCM	ICGC	PKENK	DEG_APCC_KENBOX_2	0.1389
p.Q157H	TCGA-5L-AAT1	BRCA	TCGA	PKENK	DEG_APCC_KENBOX_2	0.0833
p.Q157H	DO219594	BRCA	ICGC	PKENK	DEG_APCC_KENBOX_2	0.0833
p.P166H	TCGA-D3-A2JP	SKCM	TCGA	PKENK	DEG_APCC_KENBOX_2	0.6583
p.P166H	DO47407	SKCM	ICGC	PKENK	DEG_APCC_KENBOX_2	0.6583
p.E168K	TCGA-EE-A17Y	SKCM	TCGA	PKENK	DEG_APCC_KENBOX_2	0.7022
p.E168K	TCGA-EE-A2GO	SKCM	TCGA	PKENK	DEG_APCC_KENBOX_2	0.7022
p.E168K	DO37823	SKCM	ICGC	PKENK	DEG_APCC_KENBOX_2	0.7022
p.E168K	DO47459	SKCM	ICGC	PKENK	DEG_APCC_KENBOX_2	0.7022
p.S163C	DO233134	GACA	ICGC	PKENK	DEG_APCC_KENBOX_2	0.25
p.L156R	DO233748	GACA	ICGC	PKENK	DEG_APCC_KENBOX_2	0.0556
p.R172G	DO51014	LAML	ICGC	PKENK	DEG_APCC_KENBOX_2	0.2778
p.D178E	DO229008	LICA	ICGC	PKENK	DEG_APCC_KENBOX_2	0.1111
p.R172Q	SIDM00360	Other Solid Cancers	GDSC	PKENK	DEG_APCC_KENBOX_2	0.2778
p.R172Q	ACH-000347	Pancreatic Cancer	CCLE	PKENK	DEG_APCC_KENBOX_2	0.2778
p.R172Q	QGP-1	pancreas	COSMIC	PKENK	DEG_APCC_KENBOX_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43379	WD repeat-containing protein 62	DEG_APCC_KENBOX_2	98:102	PKENK	APC,CDC20,FZR1	0.5471	More...
P13521	Secretogranin-2	DEG_APCC_KENBOX_2	129:133	PKENK	APC,CDC20,FZR1	0.5373	More...
P14902	Indoleamine 2,3-dioxygenase 1	DEG_APCC_KENBOX_2	362:366	PKENK	APC,CDC20,FZR1	0.5041	More...
P27816	Microtubule-associated protein 4	DEG_APCC_KENBOX_2	373:377	PKENK	APC,CDC20,FZR1	0.8238	More...
P27816	Microtubule-associated protein 4	DEG_APCC_KENBOX_2	399:403	PKENK	APC,CDC20,FZR1	0.689	More...
P42568	Protein AF-9	DEG_APCC_KENBOX_2	236:240	PKENK	APC,CDC20,FZR1	0.9558	More...
Q5H9J7	Protein BEX5	DEG_APCC_KENBOX_2	5:9	PKENK	APC,CDC20,FZR1	0.6674	More...
Q8WWQ0	PH-interacting protein	DEG_APCC_KENBOX_2	763:767	PKENK	APC,CDC20,FZR1	0.8724	More...
Q96S96	Phosphatidylethanolamine-binding protein 4	DEG_APCC_KENBOX_2	166:170	PKENK	APC,CDC20,FZR1	0.761	More...
Q8IZ63	Proline-rich protein 22	DEG_APCC_KENBOX_2	188:192	PKENK	APC,CDC20,FZR1	0.9074	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons