DegronMD

Uniprot ID: P13521

Source protein: Secretogranin-2

Source gene: SCG2

Class: DEG_APCC_KENBOX_2

Location: 129:133

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5373

ASA_SCORE: 112.22

COIL: 0.8664

CONS_SCORE: 0.5975

DSS_SCORE: 0.6897

HELIX: 0.1068

FCONS_SCORE: 1

RIG_SCORE: 0.6322

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K141N	TCGA-AJ-A3EL	UCEC	TCGA	PKENK	DEG_APCC_KENBOX_2	0.2222
p.K141N	TCGA-EO-A22X	UCEC	TCGA	PKENK	DEG_APCC_KENBOX_2	0.2222
p.K141N	DO41542	UCEC	ICGC	PKENK	DEG_APCC_KENBOX_2	0.2222
p.K141N	DO43907	UCEC	ICGC	PKENK	DEG_APCC_KENBOX_2	0.2222
p.P129L	TCGA-BP-5178	KIRC	TCGA	PKENK	DEG_APCC_KENBOX_2	0.6471
p.P129L	DO18582	KIRC	ICGC	PKENK	DEG_APCC_KENBOX_2	0.6471
p.L137F	TCGA-DF-A2KV	UCEC	TCGA	PKENK	DEG_APCC_KENBOX_2	0.2222
p.L137F	TCGA-FB-AAPP	PAAD	TCGA	PKENK	DEG_APCC_KENBOX_2	0.2222
p.L137F	DO218963	PAAD	ICGC	PKENK	DEG_APCC_KENBOX_2	0.2222
p.L137F	DO219771	UCEC	ICGC	PKENK	DEG_APCC_KENBOX_2	0.2222
p.P129S	TCGA-UY-A8OB	BLCA	TCGA	PKENK	DEG_APCC_KENBOX_2	0.5641
p.P129S	DO219037	BLCA	ICGC	PKENK	DEG_APCC_KENBOX_2	0.5641
p.K141T	DO233937	GACA	ICGC	PKENK	DEG_APCC_KENBOX_2	0.2222
p.P125H	DO228974	LICA	ICGC	PKENK	DEG_APCC_KENBOX_2	0.2222
p.P125L	DO222578	MELA	ICGC	PKENK	DEG_APCC_KENBOX_2	0.2222
p.E124D	SIDM00645	Non-Small Cell Lung Carcinoma	GDSC	PKENK	DEG_APCC_KENBOX_2	0.1944
p.E124D	NCI-H1355	lung	COSMIC	PKENK	DEG_APCC_KENBOX_2	0.1944
p.A136V	SIDM00498	Colorectal Carcinoma	GDSC	PKENK	DEG_APCC_KENBOX_2	0.25
p.A136V	ACH-000970	Colon/Colorectal Cancer	CCLE	PKENK	DEG_APCC_KENBOX_2	0.25
p.A136V	SNU-C5	large_intestine	COSMIC	PKENK	DEG_APCC_KENBOX_2	0.25
p.P134L	ACH-000774	Lung Cancer	CCLE	PKENK	DEG_APCC_KENBOX_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43379	WD repeat-containing protein 62	DEG_APCC_KENBOX_2	98:102	PKENK	APC,CDC20,FZR1	0.5471	More...
P13521	Secretogranin-2	DEG_APCC_KENBOX_2	129:133	PKENK	APC,CDC20,FZR1	0.5373	More...
P14902	Indoleamine 2,3-dioxygenase 1	DEG_APCC_KENBOX_2	362:366	PKENK	APC,CDC20,FZR1	0.5041	More...
P27816	Microtubule-associated protein 4	DEG_APCC_KENBOX_2	373:377	PKENK	APC,CDC20,FZR1	0.8238	More...
P27816	Microtubule-associated protein 4	DEG_APCC_KENBOX_2	399:403	PKENK	APC,CDC20,FZR1	0.689	More...
P42568	Protein AF-9	DEG_APCC_KENBOX_2	236:240	PKENK	APC,CDC20,FZR1	0.9558	More...
Q5H9J7	Protein BEX5	DEG_APCC_KENBOX_2	5:9	PKENK	APC,CDC20,FZR1	0.6674	More...
Q8WWQ0	PH-interacting protein	DEG_APCC_KENBOX_2	763:767	PKENK	APC,CDC20,FZR1	0.8724	More...
Q96S96	Phosphatidylethanolamine-binding protein 4	DEG_APCC_KENBOX_2	166:170	PKENK	APC,CDC20,FZR1	0.761	More...
Q8IZ63	Proline-rich protein 22	DEG_APCC_KENBOX_2	188:192	PKENK	APC,CDC20,FZR1	0.9074	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons