DegronMD

Uniprot ID: O43379

Source protein: WD repeat-containing protein 62

Source gene: WDR62

Class: DEG_APCC_KENBOX_2

Location: 98:102

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5471

ASA_SCORE: 93.3

COIL: 0.9152

CONS_SCORE: 0.3519

DSS_SCORE: 0.165

HELIX: 0.0194

FCONS_SCORE: 0.8531

RIG_SCORE: 0.8112

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T109S	TCGA-77-A5G8	LUSC	TCGA	PKENK	DEG_APCC_KENBOX_2	0.1389
p.T109S	DO50099	LUSC	ICGC	PKENK	DEG_APCC_KENBOX_2	0.1389
p.C91W	TCGA-UY-A78O	BLCA	TCGA	PKENK	DEG_APCC_KENBOX_2	0.1389
p.C91W	DO219035	BLCA	ICGC	PKENK	DEG_APCC_KENBOX_2	0.1389
p.V93L	DO229022	LICA	ICGC	PKENK	DEG_APCC_KENBOX_2	0.1944
p.V93L	DO229032	LICA	ICGC	PKENK	DEG_APCC_KENBOX_2	0.1944
p.L96F	DO229032	LICA	ICGC	PKENK	DEG_APCC_KENBOX_2	0.2778
p.P98S	DO220851	MELA	ICGC	PKENK	DEG_APCC_KENBOX_2	0.5641
p.Q104H	SIDM00584	Osteosarcoma	GDSC	PKENK	DEG_APCC_KENBOX_2	0.2778
p.Q104H	SIDM00231	Kidney Carcinoma	GDSC	PKENK	DEG_APCC_KENBOX_2	0.2778
p.Q104H	SIDM00283	B-Cell Non-Hodgkin's Lymphoma	GDSC	PKENK	DEG_APCC_KENBOX_2	0.2778
p.Q104H	SIDM01551	Gastric Carcinoma	GDSC	PKENK	DEG_APCC_KENBOX_2	0.2778
p.Q104H	ACH-000485	Gastric Cancer	CCLE	PKENK	DEG_APCC_KENBOX_2	0.2778
p.Q104H	ACH-002142	Bone Cancer	CCLE	PKENK	DEG_APCC_KENBOX_2	0.2778
p.Q104H	ACH-002167	Kidney Cancer	CCLE	PKENK	DEG_APCC_KENBOX_2	0.2778
p.Q104H	ACH-002221	Lymphoma	CCLE	PKENK	DEG_APCC_KENBOX_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43379	WD repeat-containing protein 62	DEG_APCC_KENBOX_2	98:102	PKENK	APC,CDC20,FZR1	0.5471	More...
P13521	Secretogranin-2	DEG_APCC_KENBOX_2	129:133	PKENK	APC,CDC20,FZR1	0.5373	More...
P14902	Indoleamine 2,3-dioxygenase 1	DEG_APCC_KENBOX_2	362:366	PKENK	APC,CDC20,FZR1	0.5041	More...
P27816	Microtubule-associated protein 4	DEG_APCC_KENBOX_2	373:377	PKENK	APC,CDC20,FZR1	0.8238	More...
P27816	Microtubule-associated protein 4	DEG_APCC_KENBOX_2	399:403	PKENK	APC,CDC20,FZR1	0.689	More...
P42568	Protein AF-9	DEG_APCC_KENBOX_2	236:240	PKENK	APC,CDC20,FZR1	0.9558	More...
Q5H9J7	Protein BEX5	DEG_APCC_KENBOX_2	5:9	PKENK	APC,CDC20,FZR1	0.6674	More...
Q8WWQ0	PH-interacting protein	DEG_APCC_KENBOX_2	763:767	PKENK	APC,CDC20,FZR1	0.8724	More...
Q96S96	Phosphatidylethanolamine-binding protein 4	DEG_APCC_KENBOX_2	166:170	PKENK	APC,CDC20,FZR1	0.761	More...
Q8IZ63	Proline-rich protein 22	DEG_APCC_KENBOX_2	188:192	PKENK	APC,CDC20,FZR1	0.9074	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons