DegronMD

Uniprot ID: Q5H9J7

Source protein: Protein BEX5

Source gene: BEX5

Class: DEG_APCC_KENBOX_2

Location: 5:9

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6674

ASA_SCORE: 114.06

COIL: 0.713

CONS_SCORE: 0.727

DSS_SCORE: 0.7387

HELIX: 0.2864

FCONS_SCORE: 0.8932

RIG_SCORE: 0.7209

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V4D	TCGA-AD-6964	COAD	TCGA	PKENK	DEG_APCC_KENBOX_2	0.3056
p.V4D	DO8360	COAD	ICGC	PKENK	DEG_APCC_KENBOX_2	0.3056
p.V4D	SIDM00789	Colorectal Carcinoma	GDSC	PKENK	DEG_APCC_KENBOX_2	0.3056
p.V4D	ACH-000997	Colon/Colorectal Cancer	CCLE	PKENK	DEG_APCC_KENBOX_2	0.3056
p.V10A	TCGA-EO-A3AY	UCEC	TCGA	PKENK	DEG_APCC_KENBOX_2	0.3056
p.V10A	DO43202	UCEC	ICGC	PKENK	DEG_APCC_KENBOX_2	0.3056
p.A14D	DO229019	LICA	ICGC	PKENK	DEG_APCC_KENBOX_2	0.1944
p.K9R	DO23232	LINC	ICGC	PKENK	DEG_APCC_KENBOX_2	0.6126
p.P5R	SIDM00711	Squamous Cell Lung Carcinoma	GDSC	PKENK	DEG_APCC_KENBOX_2	0.6401
p.P5R	ACH-000727	Lung Cancer	CCLE	PKENK	DEG_APCC_KENBOX_2	0.6401
p.P5R	NCI-H2066	lung	COSMIC	PKENK	DEG_APCC_KENBOX_2	0.6401
p.K6T	SIDM01617	Endometrial Carcinoma	GDSC	PKENK	DEG_APCC_KENBOX_2	0.7306
p.K6T	ACH-000994	Endometrial/Uterine Cancer	CCLE	PKENK	DEG_APCC_KENBOX_2	0.7306

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43379	WD repeat-containing protein 62	DEG_APCC_KENBOX_2	98:102	PKENK	APC,CDC20,FZR1	0.5471	More...
P13521	Secretogranin-2	DEG_APCC_KENBOX_2	129:133	PKENK	APC,CDC20,FZR1	0.5373	More...
P14902	Indoleamine 2,3-dioxygenase 1	DEG_APCC_KENBOX_2	362:366	PKENK	APC,CDC20,FZR1	0.5041	More...
P27816	Microtubule-associated protein 4	DEG_APCC_KENBOX_2	373:377	PKENK	APC,CDC20,FZR1	0.8238	More...
P27816	Microtubule-associated protein 4	DEG_APCC_KENBOX_2	399:403	PKENK	APC,CDC20,FZR1	0.689	More...
P42568	Protein AF-9	DEG_APCC_KENBOX_2	236:240	PKENK	APC,CDC20,FZR1	0.9558	More...
Q5H9J7	Protein BEX5	DEG_APCC_KENBOX_2	5:9	PKENK	APC,CDC20,FZR1	0.6674	More...
Q8WWQ0	PH-interacting protein	DEG_APCC_KENBOX_2	763:767	PKENK	APC,CDC20,FZR1	0.8724	More...
Q96S96	Phosphatidylethanolamine-binding protein 4	DEG_APCC_KENBOX_2	166:170	PKENK	APC,CDC20,FZR1	0.761	More...
Q8IZ63	Proline-rich protein 22	DEG_APCC_KENBOX_2	188:192	PKENK	APC,CDC20,FZR1	0.9074	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons