DegronMD

Uniprot ID: P27816

Source protein: Microtubule-associated protein 4

Source gene: MAP4

Class: DEG_APCC_KENBOX_2

Location: 399:403

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.689

ASA_SCORE: 119.98

COIL: 0.8692

CONS_SCORE: 0.5249

DSS_SCORE: 0.5482

HELIX: 0.0624

FCONS_SCORE: 0.9782

RIG_SCORE: 0.6799

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V411A	TCGA-BR-7707	STAD	TCGA	PKENK	DEG_APCC_KENBOX_2	0.1111
p.V411A	DO38487	STAD	ICGC	PKENK	DEG_APCC_KENBOX_2	0.1111
p.K399E	DO8264	COAD	ICGC	PKENK	DEG_APCC_KENBOX_2	0.7022
p.S405N	DO228935	COCA	ICGC	PKENK	DEG_APCC_KENBOX_2	0.2778
p.E391G	DO220124	SARC	ICGC	PKENK	DEG_APCC_KENBOX_2	0.1111
p.A401T	DO38192	STAD	ICGC	PKENK	DEG_APCC_KENBOX_2	0.7139
p.S393F	SIDM00007	Other Solid Cancers	GDSC	PKENK	DEG_APCC_KENBOX_2	0.6111
p.S393F	MCC13	skin	COSMIC	PKENK	DEG_APCC_KENBOX_2	0.6111
p.P402L	ACH-000882	Skin Cancer	CCLE	PKENK	DEG_APCC_KENBOX_2	0.7582
p.P402L	IGR-1	skin	COSMIC	PKENK	DEG_APCC_KENBOX_2	0.7582
p.S410F	ACH-001550	Skin Cancer	CCLE	PKENK	DEG_APCC_KENBOX_2	0.1389
p.S410F	MCC13	skin	COSMIC	PKENK	DEG_APCC_KENBOX_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43379	WD repeat-containing protein 62	DEG_APCC_KENBOX_2	98:102	PKENK	APC,CDC20,FZR1	0.5471	More...
P13521	Secretogranin-2	DEG_APCC_KENBOX_2	129:133	PKENK	APC,CDC20,FZR1	0.5373	More...
P14902	Indoleamine 2,3-dioxygenase 1	DEG_APCC_KENBOX_2	362:366	PKENK	APC,CDC20,FZR1	0.5041	More...
P27816	Microtubule-associated protein 4	DEG_APCC_KENBOX_2	373:377	PKENK	APC,CDC20,FZR1	0.8238	More...
P27816	Microtubule-associated protein 4	DEG_APCC_KENBOX_2	399:403	PKENK	APC,CDC20,FZR1	0.689	More...
P42568	Protein AF-9	DEG_APCC_KENBOX_2	236:240	PKENK	APC,CDC20,FZR1	0.9558	More...
Q5H9J7	Protein BEX5	DEG_APCC_KENBOX_2	5:9	PKENK	APC,CDC20,FZR1	0.6674	More...
Q8WWQ0	PH-interacting protein	DEG_APCC_KENBOX_2	763:767	PKENK	APC,CDC20,FZR1	0.8724	More...
Q96S96	Phosphatidylethanolamine-binding protein 4	DEG_APCC_KENBOX_2	166:170	PKENK	APC,CDC20,FZR1	0.761	More...
Q8IZ63	Proline-rich protein 22	DEG_APCC_KENBOX_2	188:192	PKENK	APC,CDC20,FZR1	0.9074	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons