DegronMD - O43379(WDR62)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P1046L	TCGA-06-1805	GBM	TCGA	VPSSS	DEG_SPOP_SBC_1	1045:1049	Mutation altering degron motif	0.6471
p.P1046L	DO11567	GBM	ICGC	VPSSS	DEG_SPOP_SBC_1	1045:1049	Mutation altering degron motif	0.6471
p.E546D	TCGA-06-5416	GBM	TCGA	SRDRLIHVL	DEG_APCC_DBOX_1	556:564	Mutation rewiring degron network	0.0556
p.E546D	DO10880	GBM	ICGC	SRDRLIHVL	DEG_APCC_DBOX_1	556:564	Mutation rewiring degron network	0.0556
p.P1043S	TCGA-19-5956	GBM	TCGA	LPQTPEQE	DEG_SCF_FBW7_2	1050:1057	Mutation rewiring degron network	0.1389
p.P1043S	TCGA-19-5956	GBM	TCGA	VPSSS	DEG_SPOP_SBC_1	1045:1049	Mutation rewiring degron network	0.2778
p.P1043S	DO13863	GBM	ICGC	LPQTPEQE	DEG_SCF_FBW7_2	1050:1057	Mutation rewiring degron network	0.1389
p.P1043S	DO13863	GBM	ICGC	VPSSS	DEG_SPOP_SBC_1	1045:1049	Mutation rewiring degron network	0.2778
p.G75V	TCGA-21-5786	LUSC	TCGA	NRVSLEKVL	DEG_APCC_DBOX_1	58:66	Mutation rewiring degron network	0.0833
p.G75V	DO26830	LUSC	ICGC	NRVSLEKVL	DEG_APCC_DBOX_1	58:66	Mutation rewiring degron network	0.0833
p.G75V	SIDM01129	Small Cell Lung Carcinoma	GDSC	NRVSLEKVL	DEG_APCC_DBOX_1	58:66	Mutation rewiring degron network	0.0833
p.G75V	ACH-000816	Lung Cancer	CCLE	NRVSLEKVL	DEG_APCC_DBOX_1	58:66	Mutation rewiring degron network	0.0833
p.G75V	NCI-H524	lung	COSMIC	NRVSLEKVL	DEG_APCC_DBOX_1	58:66	Mutation rewiring degron network	0.0833
p.V1045I	TCGA-32-1976	GBM	TCGA	VPSSS	DEG_SPOP_SBC_1	1045:1049	Mutation altering degron motif	0.7076
p.V1045I	TCGA-A5-A0G2	UCEC	TCGA	VPSSS	DEG_SPOP_SBC_1	1045:1049	Mutation altering degron motif	0.7076
p.V1045I	DO12142	GBM	ICGC	VPSSS	DEG_SPOP_SBC_1	1045:1049	Mutation altering degron motif	0.7076
p.V1045I	DO41235	UCEC	ICGC	VPSSS	DEG_SPOP_SBC_1	1045:1049	Mutation altering degron motif	0.7076
p.R59L	TCGA-68-7757	LUSC	TCGA	NRVSLEKVL	DEG_APCC_DBOX_1	58:66	Mutation altering degron motif	0.8428
p.R59L	DO26886	LUSC	ICGC	NRVSLEKVL	DEG_APCC_DBOX_1	58:66	Mutation altering degron motif	0.8428
p.T109S	TCGA-77-A5G8	LUSC	TCGA	PKENK	DEG_APCC_KENBOX_2	98:102	Mutation rewiring degron network	0.1389
p.T109S	DO50099	LUSC	ICGC	PKENK	DEG_APCC_KENBOX_2	98:102	Mutation rewiring degron network	0.1389
p.Q574H	TCGA-86-8073	LUAD	TCGA	SRDRLIHVL	DEG_APCC_DBOX_1	556:564	Mutation rewiring degron network	0.0556
p.Q574H	DO23624	LUAD	ICGC	SRDRLIHVL	DEG_APCC_DBOX_1	556:564	Mutation rewiring degron network	0.0556
p.V566M	TCGA-AD-A5EJ	COAD	TCGA	SRDRLIHVL	DEG_APCC_DBOX_1	556:564	Mutation rewiring degron network	0.2778
p.V566M	DO50090	COAD	ICGC	SRDRLIHVL	DEG_APCC_DBOX_1	556:564	Mutation rewiring degron network	0.2778
p.R1061H	TCGA-AP-A1DV	UCEC	TCGA	LPQTPEQE	DEG_SCF_FBW7_2	1050:1057	Mutation rewiring degron network	0.2222
p.R1061H	DO43186	UCEC	ICGC	LPQTPEQE	DEG_SCF_FBW7_2	1050:1057	Mutation rewiring degron network	0.2222
p.E1041D	TCGA-BF-A1PU	SKCM	TCGA	LPQTPEQE	DEG_SCF_FBW7_2	1050:1057	Mutation rewiring degron network	0.0833
p.E1041D	TCGA-BF-A1PU	SKCM	TCGA	VPSSS	DEG_SPOP_SBC_1	1045:1049	Mutation rewiring degron network	0.2222
p.E1041D	DO50278	SKCM	ICGC	LPQTPEQE	DEG_SCF_FBW7_2	1050:1057	Mutation rewiring degron network	0.0833
p.E1041D	DO50278	SKCM	ICGC	VPSSS	DEG_SPOP_SBC_1	1045:1049	Mutation rewiring degron network	0.2222
p.E54K	TCGA-CK-4951	COAD	TCGA	NRVSLEKVL	DEG_APCC_DBOX_1	58:66	Mutation rewiring degron network	0.2222
p.E54K	DO10582	COAD	ICGC	NRVSLEKVL	DEG_APCC_DBOX_1	58:66	Mutation rewiring degron network	0.2222
p.R557Q	TCGA-D3-A1Q8	SKCM	TCGA	SRDRLIHVL	DEG_APCC_DBOX_1	556:564	Mutation altering degron motif	0.7329
p.R557Q	DO37446	SKCM	ICGC	SRDRLIHVL	DEG_APCC_DBOX_1	556:564	Mutation altering degron motif	0.7329
p.S1049F	TCGA-ER-A19E	SKCM	TCGA	VPSSS	DEG_SPOP_SBC_1	1045:1049	Mutation altering degron motif	0.9093
p.S1049F	DO47542	SKCM	ICGC	VPSSS	DEG_SPOP_SBC_1	1045:1049	Mutation altering degron motif	0.9093
p.C91W	TCGA-UY-A78O	BLCA	TCGA	PKENK	DEG_APCC_KENBOX_2	98:102	Mutation rewiring degron network	0.1389
p.C91W	DO219035	BLCA	ICGC	PKENK	DEG_APCC_KENBOX_2	98:102	Mutation rewiring degron network	0.1389
p.H1062Q	DO225335	BRCA	ICGC	LPQTPEQE	DEG_SCF_FBW7_2	1050:1057	Mutation rewiring degron network	0.1944
p.L560V	DO4155	BRCA	ICGC	SRDRLIHVL	DEG_APCC_DBOX_1	556:564	Mutation altering degron motif	0.6765
p.E63D	DO229013	COCA	ICGC	NRVSLEKVL	DEG_APCC_DBOX_1	58:66	Mutation altering degron motif	0.5647
p.V566L	DO228978	LICA	ICGC	SRDRLIHVL	DEG_APCC_DBOX_1	556:564	Mutation rewiring degron network	0.2778
p.V93L	DO229022	LICA	ICGC	PKENK	DEG_APCC_KENBOX_2	98:102	Mutation rewiring degron network	0.1944
p.V93L	DO229032	LICA	ICGC	PKENK	DEG_APCC_KENBOX_2	98:102	Mutation rewiring degron network	0.1944
p.L96F	DO229032	LICA	ICGC	PKENK	DEG_APCC_KENBOX_2	98:102	Mutation rewiring degron network	0.2778
p.P98S	DO220851	MELA	ICGC	PKENK	DEG_APCC_KENBOX_2	98:102	Mutation altering degron motif	0.5641
p.E63K	DO27893	ORCA	ICGC	NRVSLEKVL	DEG_APCC_DBOX_1	58:66	Mutation altering degron motif	0.591
p.A51T	DO232761	PBCA	ICGC	NRVSLEKVL	DEG_APCC_DBOX_1	58:66	Mutation rewiring degron network	0.1389
p.L66F	DO38404	STAD	ICGC	NRVSLEKVL	DEG_APCC_DBOX_1	58:66	Mutation altering degron motif	0.587
p.G548R	DO229224	THCA	ICGC	SRDRLIHVL	DEG_APCC_DBOX_1	556:564	Mutation rewiring degron network	0.1111
p.R559W	SIDM02049	Pancreatic Carcinoma	GDSC	SRDRLIHVL	DEG_APCC_DBOX_1	556:564	Mutation altering degron motif	0.7523
p.E1041K	SIDM00525	Osteosarcoma	GDSC	LPQTPEQE	DEG_SCF_FBW7_2	1050:1057	Mutation rewiring degron network	0.0833
p.E1041K	SIDM00525	Osteosarcoma	GDSC	VPSSS	DEG_SPOP_SBC_1	1045:1049	Mutation rewiring degron network	0.2222
p.E1041K	ACH-000359	Bone Cancer	CCLE	LPQTPEQE	DEG_SCF_FBW7_2	1050:1057	Mutation rewiring degron network	0.0833
p.E1041K	ACH-000359	Bone Cancer	CCLE	VPSSS	DEG_SPOP_SBC_1	1045:1049	Mutation rewiring degron network	0.2222
p.E1041K	MG-63	bone	COSMIC	LPQTPEQE	DEG_SCF_FBW7_2	1050:1057	Mutation rewiring degron network	0.0833
p.E1041K	MG-63	bone	COSMIC	VPSSS	DEG_SPOP_SBC_1	1045:1049	Mutation rewiring degron network	0.2222
p.Q104H	SIDM00584	Osteosarcoma	GDSC	PKENK	DEG_APCC_KENBOX_2	98:102	Mutation rewiring degron network	0.2778
p.Q104H	SIDM00231	Kidney Carcinoma	GDSC	PKENK	DEG_APCC_KENBOX_2	98:102	Mutation rewiring degron network	0.2778
p.Q104H	SIDM00283	B-Cell Non-Hodgkin's Lymphoma	GDSC	PKENK	DEG_APCC_KENBOX_2	98:102	Mutation rewiring degron network	0.2778
p.Q104H	SIDM01551	Gastric Carcinoma	GDSC	PKENK	DEG_APCC_KENBOX_2	98:102	Mutation rewiring degron network	0.2778
p.Q104H	ACH-000485	Gastric Cancer	CCLE	PKENK	DEG_APCC_KENBOX_2	98:102	Mutation rewiring degron network	0.2778
p.Q104H	ACH-002142	Bone Cancer	CCLE	PKENK	DEG_APCC_KENBOX_2	98:102	Mutation rewiring degron network	0.2778
p.Q104H	ACH-002167	Kidney Cancer	CCLE	PKENK	DEG_APCC_KENBOX_2	98:102	Mutation rewiring degron network	0.2778
p.Q104H	ACH-002221	Lymphoma	CCLE	PKENK	DEG_APCC_KENBOX_2	98:102	Mutation rewiring degron network	0.2778
p.S49W	SIDM00633	Breast Carcinoma	GDSC	NRVSLEKVL	DEG_APCC_DBOX_1	58:66	Mutation blocking phosphorylation signal	0.5278
p.E1065D	SIDM00630	Breast Carcinoma	GDSC	LPQTPEQE	DEG_SCF_FBW7_2	1050:1057	Mutation rewiring degron network	0.1111
p.E1065D	ACH-000876	Breast Cancer	CCLE	LPQTPEQE	DEG_SCF_FBW7_2	1050:1057	Mutation rewiring degron network	0.1111
p.E1065D	MDA-MB-415	breast	COSMIC	LPQTPEQE	DEG_SCF_FBW7_2	1050:1057	Mutation rewiring degron network	0.1111
p.T547M	SIDM01073	Other Blood Cancers	GDSC	SRDRLIHVL	DEG_APCC_DBOX_1	556:564	Mutation rewiring degron network	0.0833
p.T547M	ACH-002242	Leukemia	CCLE	SRDRLIHVL	DEG_APCC_DBOX_1	556:564	Mutation rewiring degron network	0.0833
p.T547M	HC-1	haematopoietic and lymphoid tissue	COSMIC	SRDRLIHVL	DEG_APCC_DBOX_1	556:564	Mutation rewiring degron network	0.0833
p.E1065A	SIDM00498	Colorectal Carcinoma	GDSC	LPQTPEQE	DEG_SCF_FBW7_2	1050:1057	Mutation rewiring degron network	0.1111
p.E1065A	SNU-C5	large intestine	COSMIC	LPQTPEQE	DEG_SCF_FBW7_2	1050:1057	Mutation rewiring degron network	0.1111
p.Q57H	SIDM00245	Small Cell Lung Carcinoma	GDSC	NRVSLEKVL	DEG_APCC_DBOX_1	58:66	Mutation rewiring degron network	0.3056
p.S554L	ACH-000841	Lung Cancer	CCLE	SRDRLIHVL	DEG_APCC_DBOX_1	556:564	Mutation rewiring degron network	0.2778
p.L1060P	ACH-000978	Endometrial/Uterine Cancer	CCLE	LPQTPEQE	DEG_SCF_FBW7_2	1050:1057	Mutation rewiring degron network	0.25
p.L1060P	EN	endometrium	COSMIC	LPQTPEQE	DEG_SCF_FBW7_2	1050:1057	Mutation rewiring degron network	0.25
p.L76I	ACH-000981	Leukemia	CCLE	NRVSLEKVL	DEG_APCC_DBOX_1	58:66	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

WDR62

UniProt ID: O43379

Entrez ID: 284403

Protein name: WD repeat-containing protein 62

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for WDR62 in