DegronMD

Uniprot ID: O43379

Source protein: WD repeat-containing protein 62

Source gene: WDR62

Class: DEG_SCF_FBW7_2

Location: 1050:1057

E3 ligase: FBXW7

DEGRON score: 0.9602

ASA_SCORE: 79.85

COIL: 0.5054

CONS_SCORE: 0.3246

DSS_SCORE: 0.6663

HELIX: 0.4823

FCONS_SCORE: 1.0234

RIG_SCORE: 0.6265

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1043S	TCGA-19-5956	GBM	TCGA	LPQTPEQE	DEG_SCF_FBW7_2	0.1389
p.P1043S	DO13863	GBM	ICGC	LPQTPEQE	DEG_SCF_FBW7_2	0.1389
p.R1061H	TCGA-AP-A1DV	UCEC	TCGA	LPQTPEQE	DEG_SCF_FBW7_2	0.2222
p.R1061H	DO43186	UCEC	ICGC	LPQTPEQE	DEG_SCF_FBW7_2	0.2222
p.E1041D	TCGA-BF-A1PU	SKCM	TCGA	LPQTPEQE	DEG_SCF_FBW7_2	0.0833
p.E1041D	DO50278	SKCM	ICGC	LPQTPEQE	DEG_SCF_FBW7_2	0.0833
p.H1062Q	DO225335	BRCA	ICGC	LPQTPEQE	DEG_SCF_FBW7_2	0.1944
p.E1041K	SIDM00525	Osteosarcoma	GDSC	LPQTPEQE	DEG_SCF_FBW7_2	0.0833
p.E1041K	ACH-000359	Bone Cancer	CCLE	LPQTPEQE	DEG_SCF_FBW7_2	0.0833
p.E1041K	MG-63	bone	COSMIC	LPQTPEQE	DEG_SCF_FBW7_2	0.0833
p.E1065D	SIDM00630	Breast Carcinoma	GDSC	LPQTPEQE	DEG_SCF_FBW7_2	0.1111
p.E1065D	ACH-000876	Breast Cancer	CCLE	LPQTPEQE	DEG_SCF_FBW7_2	0.1111
p.E1065D	MDA-MB-415	breast	COSMIC	LPQTPEQE	DEG_SCF_FBW7_2	0.1111
p.E1065A	SIDM00498	Colorectal Carcinoma	GDSC	LPQTPEQE	DEG_SCF_FBW7_2	0.1111
p.E1065A	SNU-C5	large_intestine	COSMIC	LPQTPEQE	DEG_SCF_FBW7_2	0.1111
p.L1060P	ACH-000978	Endometrial/Uterine Cancer	CCLE	LPQTPEQE	DEG_SCF_FBW7_2	0.25
p.L1060P	EN	endometrium	COSMIC	LPQTPEQE	DEG_SCF_FBW7_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43379	WD repeat-containing protein 62	DEG_SCF_FBW7_2	1050:1057	LPQTPEQE	FBXW7	0.9602	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons