DegronMD

Uniprot ID: O43379

Source protein: WD repeat-containing protein 62

Source gene: WDR62

Class: DEG_APCC_DBOX_1

Location: 58:66

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9605

ASA_SCORE: 54.8

COIL: 0.2246

CONS_SCORE: 0.415

DSS_SCORE: 0.339

HELIX: 0.053

FCONS_SCORE: 1.1626

RIG_SCORE: 0.8286

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G75V	TCGA-21-5786	LUSC	TCGA	NRVSLEKVL	DEG_APCC_DBOX_1	0.0833
p.G75V	DO26830	LUSC	ICGC	NRVSLEKVL	DEG_APCC_DBOX_1	0.0833
p.G75V	SIDM01129	Small Cell Lung Carcinoma	GDSC	NRVSLEKVL	DEG_APCC_DBOX_1	0.0833
p.G75V	ACH-000816	Lung Cancer	CCLE	NRVSLEKVL	DEG_APCC_DBOX_1	0.0833
p.G75V	NCI-H524	lung	COSMIC	NRVSLEKVL	DEG_APCC_DBOX_1	0.0833
p.R59L	TCGA-68-7757	LUSC	TCGA	NRVSLEKVL	DEG_APCC_DBOX_1	0.8428
p.R59L	DO26886	LUSC	ICGC	NRVSLEKVL	DEG_APCC_DBOX_1	0.8428
p.E54K	TCGA-CK-4951	COAD	TCGA	NRVSLEKVL	DEG_APCC_DBOX_1	0.2222
p.E54K	DO10582	COAD	ICGC	NRVSLEKVL	DEG_APCC_DBOX_1	0.2222
p.E63D	DO229013	COCA	ICGC	NRVSLEKVL	DEG_APCC_DBOX_1	0.5647
p.E63K	DO27893	ORCA	ICGC	NRVSLEKVL	DEG_APCC_DBOX_1	0.591
p.A51T	DO232761	PBCA	ICGC	NRVSLEKVL	DEG_APCC_DBOX_1	0.1389
p.L66F	DO38404	STAD	ICGC	NRVSLEKVL	DEG_APCC_DBOX_1	0.587
p.S49W	SIDM00633	Breast Carcinoma	GDSC	NRVSLEKVL	DEG_APCC_DBOX_1	0.5278
p.Q57H	SIDM00245	Small Cell Lung Carcinoma	GDSC	NRVSLEKVL	DEG_APCC_DBOX_1	0.3056
p.L76I	ACH-000981	Leukemia	CCLE	NRVSLEKVL	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43379	WD repeat-containing protein 62	DEG_APCC_DBOX_1	58:66	NRVSLEKVL	APC,CDC20,FZR1	0.9605	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons