DegronMD

Uniprot ID: O43379

Source protein: WD repeat-containing protein 62

Source gene: WDR62

Class: DEG_APCC_DBOX_1

Location: 556:564

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5378

ASA_SCORE: 26.6556

COIL: 0.4481

CONS_SCORE: 0.617

DSS_SCORE: 0.1164

HELIX: 0.0031

FCONS_SCORE: 1.4789

RIG_SCORE: 0.8464

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E546D	TCGA-06-5416	GBM	TCGA	SRDRLIHVL	DEG_APCC_DBOX_1	0.0556
p.E546D	DO10880	GBM	ICGC	SRDRLIHVL	DEG_APCC_DBOX_1	0.0556
p.Q574H	TCGA-86-8073	LUAD	TCGA	SRDRLIHVL	DEG_APCC_DBOX_1	0.0556
p.Q574H	DO23624	LUAD	ICGC	SRDRLIHVL	DEG_APCC_DBOX_1	0.0556
p.V566M	TCGA-AD-A5EJ	COAD	TCGA	SRDRLIHVL	DEG_APCC_DBOX_1	0.2778
p.V566M	DO50090	COAD	ICGC	SRDRLIHVL	DEG_APCC_DBOX_1	0.2778
p.R557Q	TCGA-D3-A1Q8	SKCM	TCGA	SRDRLIHVL	DEG_APCC_DBOX_1	0.7329
p.R557Q	DO37446	SKCM	ICGC	SRDRLIHVL	DEG_APCC_DBOX_1	0.7329
p.L560V	DO4155	BRCA	ICGC	SRDRLIHVL	DEG_APCC_DBOX_1	0.6765
p.V566L	DO228978	LICA	ICGC	SRDRLIHVL	DEG_APCC_DBOX_1	0.2778
p.G548R	DO229224	THCA	ICGC	SRDRLIHVL	DEG_APCC_DBOX_1	0.1111
p.R559W	SIDM02049	Pancreatic Carcinoma	GDSC	SRDRLIHVL	DEG_APCC_DBOX_1	0.7523
p.T547M	SIDM01073	Other Blood Cancers	GDSC	SRDRLIHVL	DEG_APCC_DBOX_1	0.0833
p.T547M	ACH-002242	Leukemia	CCLE	SRDRLIHVL	DEG_APCC_DBOX_1	0.0833
p.T547M	HC-1	haematopoietic_and_lymphoid_tissue	COSMIC	SRDRLIHVL	DEG_APCC_DBOX_1	0.0833
p.S554L	ACH-000841	Lung Cancer	CCLE	SRDRLIHVL	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43379	WD repeat-containing protein 62	DEG_APCC_DBOX_1	556:564	SRDRLIHVL	APC,CDC20,FZR1	0.5378	More...
O60336	Mitogen-activated protein kinase-binding protein 1	DEG_APCC_DBOX_1	543:551	SRDRLIHVL	APC,CDC20,FZR1	0.5285	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons