DegronMD - O60336(MAPKBP1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R743H	TCGA-06-2563	GBM	TCGA	MRQRLAELR	DEG_APCC_DBOX_1	740:748	Mutation altering degron motif	0.7133
p.R743H	TCGA-AA-3684	COAD	TCGA	MRQRLAELR	DEG_APCC_DBOX_1	740:748	Mutation altering degron motif	0.7133
p.R1111W	TCGA-14-0866	GBM	TCGA	PSSSS	DEG_SPOP_SBC_1	1115:1119	Mutation rewiring degron network	0.2222
p.V972E	TCGA-56-A62T	LUSC	TCGA	ARGTLGRVY	DEG_APCC_DBOX_1	976:984	Mutation rewiring degron network	0.2222
p.K1257N	TCGA-86-7955	LUAD	TCGA	PTTSS	DEG_SPOP_SBC_1	1250:1254	Mutation substituting flanking lysine	0.3611
p.H1072R	TCGA-94-8491	LUSC	TCGA	PQTPDQE	DEG_SCF_FBW7_2	1060:1066	Mutation rewiring degron network	0.1667
p.R731C	TCGA-B5-A3FC	UCEC	TCGA	MRQRLAELR	DEG_APCC_DBOX_1	740:748	Mutation rewiring degron network	0.0833
p.P1328S	TCGA-BR-4370	STAD	TCGA	AHSTT	DEG_SPOP_SBC_1	1337:1341	Mutation rewiring degron network	0.0833
p.R731H	TCGA-CD-8531	STAD	TCGA	MRQRLAELR	DEG_APCC_DBOX_1	740:748	Mutation rewiring degron network	0.0833
p.R1243W	TCGA-CG-4460	STAD	TCGA	PTTSS	DEG_SPOP_SBC_1	1250:1254	Mutation rewiring degron network	0.1389
p.R1243Q	TCGA-CV-6938	HNSC	TCGA	PTTSS	DEG_SPOP_SBC_1	1250:1254	Mutation rewiring degron network	0.1389
p.Q751R	TCGA-D9-A6EC	SKCM	TCGA	MRQRLAELR	DEG_APCC_DBOX_1	740:748	Mutation rewiring degron network	0.25
p.R544W	TCGA-DU-6392	LGG	TCGA	SRDRLIHVL	DEG_APCC_DBOX_1	543:551	Mutation altering degron motif	0.8634
p.P1331S	TCGA-EE-A3J7	SKCM	TCGA	AHSTT	DEG_SPOP_SBC_1	1337:1341	Mutation rewiring degron network	0.1667
p.S1263Y	TCGA-EO-A22R	UCEC	TCGA	PTTSS	DEG_SPOP_SBC_1	1250:1254	Mutation blocking phosphorylation signal	0.5278
p.R1260C	TCGA-FY-A40N	THCA	TCGA	PTTSS	DEG_SPOP_SBC_1	1250:1254	Mutation rewiring degron network	0.1667
p.P1241L	TCGA-GN-A262	SKCM	TCGA	PTTSS	DEG_SPOP_SBC_1	1250:1254	Mutation rewiring degron network	0.0833
p.P1241L	SIDM00303	Ovarian Carcinoma	GDSC	PTTSS	DEG_SPOP_SBC_1	1250:1254	Mutation rewiring degron network	0.0833
p.P1241L	SIDM00611	Kidney Carcinoma	GDSC	PTTSS	DEG_SPOP_SBC_1	1250:1254	Mutation rewiring degron network	0.0833
p.P1241L	SIDM01197	Colorectal Carcinoma	GDSC	PTTSS	DEG_SPOP_SBC_1	1250:1254	Mutation rewiring degron network	0.0833
p.P1241L	SIDM00352	Ovarian Carcinoma	GDSC	PTTSS	DEG_SPOP_SBC_1	1250:1254	Mutation rewiring degron network	0.0833
p.P1241L	SIDM00551	Esophageal Squamous Cell Carcinoma	GDSC	PTTSS	DEG_SPOP_SBC_1	1250:1254	Mutation rewiring degron network	0.0833
p.P1241L	SIDM00544	Neuroblastoma	GDSC	PTTSS	DEG_SPOP_SBC_1	1250:1254	Mutation rewiring degron network	0.0833
p.P1241L	SIDM00235	Kidney Carcinoma	GDSC	PTTSS	DEG_SPOP_SBC_1	1250:1254	Mutation rewiring degron network	0.0833
p.P1241L	SIDM01146	Gastric Carcinoma	GDSC	PTTSS	DEG_SPOP_SBC_1	1250:1254	Mutation rewiring degron network	0.0833
p.P1241L	SIDM00502	B-Lymphoblastic Leukemia	GDSC	PTTSS	DEG_SPOP_SBC_1	1250:1254	Mutation rewiring degron network	0.0833
p.P1241L	SIDM00245	Small Cell Lung Carcinoma	GDSC	PTTSS	DEG_SPOP_SBC_1	1250:1254	Mutation rewiring degron network	0.0833
p.P1241L	SIDM00575	Glioma	GDSC	PTTSS	DEG_SPOP_SBC_1	1250:1254	Mutation rewiring degron network	0.0833
p.P1241L	SIDM01435	Hepatocellular Carcinoma	GDSC	PTTSS	DEG_SPOP_SBC_1	1250:1254	Mutation rewiring degron network	0.0833
p.P1241L	SIDM01587	Bladder Carcinoma	GDSC	PTTSS	DEG_SPOP_SBC_1	1250:1254	Mutation rewiring degron network	0.0833
p.P1241L	SIDM00015	Esophageal Squamous Cell Carcinoma	GDSC	PTTSS	DEG_SPOP_SBC_1	1250:1254	Mutation rewiring degron network	0.0833
p.P1241L	JHOS-4	ovary	COSMIC	PTTSS	DEG_SPOP_SBC_1	1250:1254	Mutation rewiring degron network	0.0833
p.E1342K	TCGA-K4-A5RJ	BLCA	TCGA	AHSTT	DEG_SPOP_SBC_1	1337:1341	Mutation rewiring degron network	0.3056
p.A540E	TCGA-SX-A7SS	KIRP	TCGA	SRDRLIHVL	DEG_APCC_DBOX_1	543:551	Mutation rewiring degron network	0.25
p.E1336K	DO49784	BLCA	ICGC	AHSTT	DEG_SPOP_SBC_1	1337:1341	Mutation rewiring degron network	0.3056
p.E1343K	DO220823	BRCA	ICGC	AHSTT	DEG_SPOP_SBC_1	1337:1341	Mutation rewiring degron network	0.2778
p.R540Q	DO222427	BTCA	ICGC	SRDRLIHVL	DEG_APCC_DBOX_1	543:551	Mutation rewiring degron network	0.25
p.R744H	DO229355	BTCA	ICGC	MRQRLAELR	DEG_APCC_DBOX_1	740:748	Mutation altering degron motif	0.8244
p.R744H	ACH-000258	Breast Cancer	CCLE	MRQRLAELR	DEG_APCC_DBOX_1	740:748	Mutation altering degron motif	0.8244
p.R744H	DU-4475	breast	COSMIC	MRQRLAELR	DEG_APCC_DBOX_1	740:748	Mutation altering degron motif	0.8244
p.R737H	DO8802	COAD	ICGC	MRQRLAELR	DEG_APCC_DBOX_1	740:748	Mutation rewiring degron network	0.25
p.R737H	DO11525	GBM	ICGC	MRQRLAELR	DEG_APCC_DBOX_1	740:748	Mutation rewiring degron network	0.25
p.S1110P	DO222874	COCA	ICGC	PSSSS	DEG_SPOP_SBC_1	1115:1119	Mutation rewiring degron network	0.1944
p.Q1065H	DO222884	COCA	ICGC	PQTPDQE	DEG_SCF_FBW7_2	1060:1066	Mutation altering degron motif	0.647
p.G1344C	DO229013	COCA	ICGC	AHSTT	DEG_SPOP_SBC_1	1337:1341	Mutation rewiring degron network	0.25
p.R1105W	DO11878	GBM	ICGC	PSSSS	DEG_SPOP_SBC_1	1115:1119	Mutation rewiring degron network	0.0556
p.G1259W	DO11878	GBM	ICGC	PTTSS	DEG_SPOP_SBC_1	1250:1254	Mutation rewiring degron network	0.1944
p.R1105K	DO11854	GBM	ICGC	PSSSS	DEG_SPOP_SBC_1	1115:1119	Mutation rewiring degron network	0.0556
p.E559K	DO14694	HNSC	ICGC	SRDRLIHVL	DEG_APCC_DBOX_1	543:551	Mutation rewiring degron network	0.1111
p.E559K	DO229051	LICA	ICGC	SRDRLIHVL	DEG_APCC_DBOX_1	543:551	Mutation rewiring degron network	0.1111
p.A534E	DO49794	KIRP	ICGC	SRDRLIHVL	DEG_APCC_DBOX_1	543:551	Mutation rewiring degron network	0.0833
p.R538W	DO22237	LGG	ICGC	SRDRLIHVL	DEG_APCC_DBOX_1	543:551	Mutation rewiring degron network	0.1944
p.R746L	DO228974	LICA	ICGC	MRQRLAELR	DEG_APCC_DBOX_1	740:748	Mutation altering degron motif	0.8428
p.E1343D	DO229018	LICA	ICGC	AHSTT	DEG_SPOP_SBC_1	1337:1341	Mutation rewiring degron network	0.2778
p.A1250S	DO229015	LICA	ICGC	PTTSS	DEG_SPOP_SBC_1	1250:1254	Mutation altering degron motif	0.7588
p.G748C	DO229038	LICA	ICGC	MRQRLAELR	DEG_APCC_DBOX_1	740:748	Mutation altering degron motif	0.76
p.K1251N	DO23612	LUAD	ICGC	PTTSS	DEG_SPOP_SBC_1	1250:1254	Mutation altering degron motif	0.6918
p.H1066R	DO219174	LUSC	ICGC	PQTPDQE	DEG_SCF_FBW7_2	1060:1066	Mutation altering degron motif	0.8244
p.V966E	DO219144	LUSC	ICGC	ARGTLGRVY	DEG_APCC_DBOX_1	976:984	Mutation rewiring degron network	0.0556
p.Q555H	DO233296	NACA	ICGC	SRDRLIHVL	DEG_APCC_DBOX_1	543:551	Mutation rewiring degron network	0.2222
p.Q745R	DO50291	SKCM	ICGC	MRQRLAELR	DEG_APCC_DBOX_1	740:748	Mutation altering degron motif	0.7329
p.R1254C	DO38905	THCA	ICGC	PTTSS	DEG_SPOP_SBC_1	1250:1254	Mutation altering degron motif	0.8301
p.S1257Y	DO42713	UCEC	ICGC	PTTSS	DEG_SPOP_SBC_1	1250:1254	Mutation substituting flanking lysine	0.3611
p.G1350C	SIDM00353	Other Sarcomas	GDSC	AHSTT	DEG_SPOP_SBC_1	1337:1341	Mutation rewiring degron network	0.0833
p.G1350C	SIDM00547	Non-Small Cell Lung Carcinoma	GDSC	AHSTT	DEG_SPOP_SBC_1	1337:1341	Mutation rewiring degron network	0.0833
p.G1350C	SIDM00544	Neuroblastoma	GDSC	AHSTT	DEG_SPOP_SBC_1	1337:1341	Mutation rewiring degron network	0.0833
p.G1350C	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	AHSTT	DEG_SPOP_SBC_1	1337:1341	Mutation rewiring degron network	0.0833
p.G1350C	SIDM00348	Esophageal Squamous Cell Carcinoma	GDSC	AHSTT	DEG_SPOP_SBC_1	1337:1341	Mutation rewiring degron network	0.0833
p.G1350C	SIDM00587	Biliary Tract Carcinoma	GDSC	AHSTT	DEG_SPOP_SBC_1	1337:1341	Mutation rewiring degron network	0.0833
p.G1350C	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	AHSTT	DEG_SPOP_SBC_1	1337:1341	Mutation rewiring degron network	0.0833
p.G1350C	SIDM01617	Endometrial Carcinoma	GDSC	AHSTT	DEG_SPOP_SBC_1	1337:1341	Mutation rewiring degron network	0.0833
p.G1350C	SIDM01779	Gastric Carcinoma	GDSC	AHSTT	DEG_SPOP_SBC_1	1337:1341	Mutation rewiring degron network	0.0833
p.G1350C	SIDM01559	Melanoma	GDSC	AHSTT	DEG_SPOP_SBC_1	1337:1341	Mutation rewiring degron network	0.0833
p.S1118L	SIDM00373	Endometrial Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	1115:1119	Mutation altering degron motif	0.7667
p.S1118L	SIDM00370	T-Lymphoblastic Leukemia	GDSC	PSSSS	DEG_SPOP_SBC_1	1115:1119	Mutation altering degron motif	0.7667
p.S1118L	SIDM00465	Ovarian Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	1115:1119	Mutation altering degron motif	0.7667
p.S1118L	SIDM00592	Oral Cavity Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	1115:1119	Mutation altering degron motif	0.7667
p.S1118L	SIDM00970	Bladder Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	1115:1119	Mutation altering degron motif	0.7667
p.S1118L	SIDM00397	Acute Myeloid Leukemia	GDSC	PSSSS	DEG_SPOP_SBC_1	1115:1119	Mutation altering degron motif	0.7667
p.S1118L	SIDM00326	Esophageal Squamous Cell Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	1115:1119	Mutation altering degron motif	0.7667
p.S1118L	SIDM00591	Oral Cavity Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	1115:1119	Mutation altering degron motif	0.7667
p.S1118L	SIDM01033	Bladder Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	1115:1119	Mutation altering degron motif	0.7667
p.S1118L	SIDM00016	Neuroblastoma	GDSC	PSSSS	DEG_SPOP_SBC_1	1115:1119	Mutation altering degron motif	0.7667
p.S1118L	Set2	haematopoietic and lymphoid tissue	COSMIC	PSSSS	DEG_SPOP_SBC_1	1115:1119	Mutation altering degron motif	0.7667
p.S1118L	SNG-M	endometrium	COSMIC	PSSSS	DEG_SPOP_SBC_1	1115:1119	Mutation altering degron motif	0.7667
p.A1127S	SIDM00001	Other Blood Cancers	GDSC	PSSSS	DEG_SPOP_SBC_1	1115:1119	Mutation rewiring degron network	0.1111
p.R752W	SIDM00759	Non-Small Cell Lung Carcinoma	GDSC	MRQRLAELR	DEG_APCC_DBOX_1	740:748	Mutation rewiring degron network	0.2222
p.R752W	SIDM01190	Bladder Carcinoma	GDSC	MRQRLAELR	DEG_APCC_DBOX_1	740:748	Mutation rewiring degron network	0.2222
p.R752W	SIDM00929	Chondrosarcoma	GDSC	MRQRLAELR	DEG_APCC_DBOX_1	740:748	Mutation rewiring degron network	0.2222
p.R752W	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	MRQRLAELR	DEG_APCC_DBOX_1	740:748	Mutation rewiring degron network	0.2222
p.P1063L	SIDM00392	Melanoma	GDSC	PQTPDQE	DEG_SCF_FBW7_2	1060:1066	Mutation altering degron motif	0.7582
p.P1063L	SK-MEL-30	skin	COSMIC	PQTPDQE	DEG_SCF_FBW7_2	1060:1066	Mutation altering degron motif	0.7582
p.C1346Y	SIDM00690	Head and Neck Carcinoma	GDSC	AHSTT	DEG_SPOP_SBC_1	1337:1341	Mutation rewiring degron network	0.1944
p.C1346Y	JHU-029	upper aerodigestive tract	COSMIC	AHSTT	DEG_SPOP_SBC_1	1337:1341	Mutation rewiring degron network	0.1944
p.V1264A	SIDM01157	Other Solid Cancers	GDSC	PTTSS	DEG_SPOP_SBC_1	1250:1254	Mutation rewiring degron network	0.0556
p.V1264A	SW954	vulva	COSMIC	PTTSS	DEG_SPOP_SBC_1	1250:1254	Mutation rewiring degron network	0.0556
p.A542V	SIDM00145	T-Lymphoblastic Leukemia	GDSC	SRDRLIHVL	DEG_APCC_DBOX_1	543:551	Mutation rewiring degron network	0.3056
p.A542V	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	SRDRLIHVL	DEG_APCC_DBOX_1	543:551	Mutation rewiring degron network	0.3056
p.R750H	SIDM01001	Breast Carcinoma	GDSC	MRQRLAELR	DEG_APCC_DBOX_1	740:748	Mutation rewiring degron network	0.2778
p.R750H	DU-4475	breast	COSMIC	MRQRLAELR	DEG_APCC_DBOX_1	740:748	Mutation rewiring degron network	0.2778
p.S1253C	SIDM01628	Non-Small Cell Lung Carcinoma	GDSC	PTTSS	DEG_SPOP_SBC_1	1250:1254	Mutation altering degron motif	0.7541
p.S1253I	SIDM01628	Non-Small Cell Lung Carcinoma	GDSC	PTTSS	DEG_SPOP_SBC_1	1250:1254	Mutation altering degron motif	0.7341
p.S1112L	ACH-000195	Leukemia	CCLE	PSSSS	DEG_SPOP_SBC_1	1115:1119	Mutation rewiring degron network	0.25
p.S1112L	ACH-000197	Leukemia	CCLE	PSSSS	DEG_SPOP_SBC_1	1115:1119	Mutation rewiring degron network	0.25
p.S1112L	ACH-000446	Neuroblastoma	CCLE	PSSSS	DEG_SPOP_SBC_1	1115:1119	Mutation rewiring degron network	0.25
p.S1112L	ACH-000452	Esophageal Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	1115:1119	Mutation rewiring degron network	0.25
p.S1112L	ACH-000486	Bladder Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	1115:1119	Mutation rewiring degron network	0.25
p.S1112L	ACH-000974	Endometrial/Uterine Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	1115:1119	Mutation rewiring degron network	0.25
p.S1112L	ACH-001184	Sarcoma	CCLE	PSSSS	DEG_SPOP_SBC_1	1115:1119	Mutation rewiring degron network	0.25
p.S1112L	ACH-001230	Leukemia	CCLE	PSSSS	DEG_SPOP_SBC_1	1115:1119	Mutation rewiring degron network	0.25
p.S1112L	ACH-001856	Bile Duct Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	1115:1119	Mutation rewiring degron network	0.25
p.S1112L	ACH-002026	Endometrial/Uterine Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	1115:1119	Mutation rewiring degron network	0.25
p.S1112L	ACH-002045	Head and Neck Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	1115:1119	Mutation rewiring degron network	0.25
p.S1112L	ACH-002183	Ovarian Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	1115:1119	Mutation rewiring degron network	0.25
p.S1112L	ACH-002235	Bladder Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	1115:1119	Mutation rewiring degron network	0.25
p.S1112L	ACH-002244	Head and Neck Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	1115:1119	Mutation rewiring degron network	0.25
p.S1112L	Set2	haematopoietic and lymphoid tissue	COSMIC	PSSSS	DEG_SPOP_SBC_1	1115:1119	Mutation rewiring degron network	0.25
p.S1112L	SNG-M	endometrium	COSMIC	PSSSS	DEG_SPOP_SBC_1	1115:1119	Mutation rewiring degron network	0.25
p.A1121S	ACH-000405	Leukemia	CCLE	PSSSS	DEG_SPOP_SBC_1	1115:1119	Mutation rewiring degron network	0.2778
p.P1057L	ACH-000810	Skin Cancer	CCLE	PQTPDQE	DEG_SCF_FBW7_2	1060:1066	Mutation rewiring degron network	0.25
p.P1057L	SK-MEL-30	skin	COSMIC	PQTPDQE	DEG_SCF_FBW7_2	1060:1066	Mutation rewiring degron network	0.25
p.S1253F	ACH-000851	Lung Cancer	CCLE	PTTSS	DEG_SPOP_SBC_1	1250:1254	Mutation altering degron motif	0.7982
p.S1247I	ACH-000851	Lung Cancer	CCLE	PTTSS	DEG_SPOP_SBC_1	1250:1254	Mutation rewiring degron network	0.25
p.R977W	ACH-000960	Leukemia	CCLE	ARGTLGRVY	DEG_APCC_DBOX_1	976:984	Mutation altering degron motif	0.8634
p.A536V	ACH-001127	Leukemia	CCLE	SRDRLIHVL	DEG_APCC_DBOX_1	543:551	Mutation rewiring degron network	0.1389
p.A536V	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	SRDRLIHVL	DEG_APCC_DBOX_1	543:551	Mutation rewiring degron network	0.1389
p.V1258A	ACH-001400	Cervical Cancer	CCLE	PTTSS	DEG_SPOP_SBC_1	1250:1254	Mutation rewiring degron network	0.2222
p.V1258A	SW954	vulva	COSMIC	PTTSS	DEG_SPOP_SBC_1	1250:1254	Mutation rewiring degron network	0.2222
p.P753L	ACH-001864	Bile Duct Cancer	CCLE	MRQRLAELR	DEG_APCC_DBOX_1	740:748	Mutation rewiring degron network	0.1944
p.C1340Y	ACH-002251	Head and Neck Cancer	CCLE	AHSTT	DEG_SPOP_SBC_1	1337:1341	Mutation altering degron motif	0.7087
p.C1340Y	JHU-029	upper aerodigestive tract	COSMIC	AHSTT	DEG_SPOP_SBC_1	1337:1341	Mutation altering degron motif	0.7087

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MAPKBP1

UniProt ID: O60336

Entrez ID: 23005

Protein name: Mitogen-activated protein kinase-binding protein 1 (JNK-binding protein 1) (JNKBP-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MAPKBP1 in