DegronMD

Uniprot ID: O60336

Source protein: Mitogen-activated protein kinase-binding protein 1

Source gene: MAPKBP1

Class: DEG_SPOP_SBC_1

Location: 1250:1254

E3 ligase: SPOP

DEGRON score: 0.9955

ASA_SCORE: 76

COIL: 0.8342

CONS_SCORE: 0.2148

DSS_SCORE: 0.6408

HELIX: 0.1226

FCONS_SCORE: 0.9619

RIG_SCORE: 0.6358

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K1257N	TCGA-86-7955	LUAD	TCGA	PTTSS	DEG_SPOP_SBC_1	0.3611
p.R1243W	TCGA-CG-4460	STAD	TCGA	PTTSS	DEG_SPOP_SBC_1	0.1389
p.R1243Q	TCGA-CV-6938	HNSC	TCGA	PTTSS	DEG_SPOP_SBC_1	0.1389
p.S1263Y	TCGA-EO-A22R	UCEC	TCGA	PTTSS	DEG_SPOP_SBC_1	0.5278
p.R1260C	TCGA-FY-A40N	THCA	TCGA	PTTSS	DEG_SPOP_SBC_1	0.1667
p.P1241L	TCGA-GN-A262	SKCM	TCGA	PTTSS	DEG_SPOP_SBC_1	0.0833
p.P1241L	SIDM00303	Ovarian Carcinoma	GDSC	PTTSS	DEG_SPOP_SBC_1	0.0833
p.P1241L	SIDM00611	Kidney Carcinoma	GDSC	PTTSS	DEG_SPOP_SBC_1	0.0833
p.P1241L	SIDM01197	Colorectal Carcinoma	GDSC	PTTSS	DEG_SPOP_SBC_1	0.0833
p.P1241L	SIDM00352	Ovarian Carcinoma	GDSC	PTTSS	DEG_SPOP_SBC_1	0.0833
p.P1241L	SIDM00551	Esophageal Squamous Cell Carcinoma	GDSC	PTTSS	DEG_SPOP_SBC_1	0.0833
p.P1241L	SIDM00544	Neuroblastoma	GDSC	PTTSS	DEG_SPOP_SBC_1	0.0833
p.P1241L	SIDM00235	Kidney Carcinoma	GDSC	PTTSS	DEG_SPOP_SBC_1	0.0833
p.P1241L	SIDM01146	Gastric Carcinoma	GDSC	PTTSS	DEG_SPOP_SBC_1	0.0833
p.P1241L	SIDM00502	B-Lymphoblastic Leukemia	GDSC	PTTSS	DEG_SPOP_SBC_1	0.0833
p.P1241L	SIDM00245	Small Cell Lung Carcinoma	GDSC	PTTSS	DEG_SPOP_SBC_1	0.0833
p.P1241L	SIDM00575	Glioma	GDSC	PTTSS	DEG_SPOP_SBC_1	0.0833
p.P1241L	SIDM01435	Hepatocellular Carcinoma	GDSC	PTTSS	DEG_SPOP_SBC_1	0.0833
p.P1241L	SIDM01587	Bladder Carcinoma	GDSC	PTTSS	DEG_SPOP_SBC_1	0.0833
p.P1241L	SIDM00015	Esophageal Squamous Cell Carcinoma	GDSC	PTTSS	DEG_SPOP_SBC_1	0.0833
p.P1241L	JHOS-4	ovary	COSMIC	PTTSS	DEG_SPOP_SBC_1	0.0833
p.G1259W	DO11878	GBM	ICGC	PTTSS	DEG_SPOP_SBC_1	0.1944
p.A1250S	DO229015	LICA	ICGC	PTTSS	DEG_SPOP_SBC_1	0.7588
p.K1251N	DO23612	LUAD	ICGC	PTTSS	DEG_SPOP_SBC_1	0.6918
p.R1254C	DO38905	THCA	ICGC	PTTSS	DEG_SPOP_SBC_1	0.8301
p.S1257Y	DO42713	UCEC	ICGC	PTTSS	DEG_SPOP_SBC_1	0.3611
p.V1264A	SIDM01157	Other Solid Cancers	GDSC	PTTSS	DEG_SPOP_SBC_1	0.0556
p.V1264A	SW954	vulva	COSMIC	PTTSS	DEG_SPOP_SBC_1	0.0556
p.S1253C	SIDM01628	Non-Small Cell Lung Carcinoma	GDSC	PTTSS	DEG_SPOP_SBC_1	0.7541
p.S1253I	SIDM01628	Non-Small Cell Lung Carcinoma	GDSC	PTTSS	DEG_SPOP_SBC_1	0.7341
p.S1253F	ACH-000851	Lung Cancer	CCLE	PTTSS	DEG_SPOP_SBC_1	0.7982
p.S1247I	ACH-000851	Lung Cancer	CCLE	PTTSS	DEG_SPOP_SBC_1	0.25
p.V1258A	ACH-001400	Cervical Cancer	CCLE	PTTSS	DEG_SPOP_SBC_1	0.2222
p.V1258A	SW954	vulva	COSMIC	PTTSS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14776	Transcription elongation regulator 1	DEG_SPOP_SBC_1	261:265	PTTSS	SPOP	0.9948	More...
O15054	Lysine-specific demethylase 6B	DEG_SPOP_SBC_1	549:553	PTTSS	SPOP	0.8155	More...
O60336	Mitogen-activated protein kinase-binding protein 1	DEG_SPOP_SBC_1	1250:1254	PTTSS	SPOP	0.9955	More...
P35869	Aryl hydrocarbon receptor	DEG_SPOP_SBC_1	730:734	PTTSS	SPOP	0.9973	More...
P55055	Oxysterols receptor LXR-beta	DEG_SPOP_SBC_1	4:8	PTTSS	SPOP	0.9972	More...
Q12955	Ankyrin-3	DEG_SPOP_SBC_1	2207:2211	PTTSS	SPOP	0.9961	More...
Q15915	Zinc finger protein ZIC 1	DEG_SPOP_SBC_1	417:421	PTTSS	SPOP	0.9909	More...
Q7Z7G0	Target of Nesh-SH3	DEG_SPOP_SBC_1	341:345	PTTSS	SPOP	0.992	More...
Q8IZF0	Sodium leak channel NALCN	DEG_SPOP_SBC_1	682:686	PTTSS	SPOP	0.8231	More...
Q8N0V3	Putative ribosome-binding factor A, mitochondrial	DEG_SPOP_SBC_1	230:234	PTTSS	SPOP	0.9938	More...
Q8N7W2	BEN domain-containing protein 7	DEG_SPOP_SBC_1	144:148	PTTSS	SPOP	0.6957	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	6756:6760	PTTSS	SPOP	0.7898	More...
Q9BRK4	Leucine zipper putative tumor suppressor 2	DEG_SPOP_SBC_1	238:242	PTTSS	SPOP	0.9196	More...
Q9H1H9	Kinesin-like protein KIF13A	DEG_SPOP_SBC_1	1590:1594	PTTSS	SPOP	0.9958	More...
Q9H254	Spectrin beta chain, non-erythrocytic 4	DEG_SPOP_SBC_1	2540:2544	PTTSS	SPOP	0.9961	More...
Q9Y5J3	Hairy/enhancer-of-split related with YRPW motif protein 1	DEG_SPOP_SBC_1	41:45	PTTSS	SPOP	0.6104	More...
Q9H3M9	Ataxin-3-like protein	DEG_SPOP_SBC_1	314:318	PTTSS	SPOP	0.999	More...
O75333	T-box transcription factor TBX10	DEG_SPOP_SBC_1	21:25	PTTSS	SPOP	0.988	More...
Q5JXX7	Transmembrane protein 31	DEG_SPOP_SBC_1	60:64	PTTSS	SPOP	0.5118	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTTSS

Degron related mutations and impact score

Drug responses associated with MAPKBP1 mutations

All proteins holding degron of PTTSS