DegronMD - Q9H1H9(KIF13A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L532P	TCGA-06-0649	GBM	TCGA	VCSTT	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.0833
p.L532P	DO11142	GBM	ICGC	VCSTT	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.0833
p.T517I	TCGA-21-1079	LUSC	TCGA	VCSTT	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.2778
p.T517I	DO26846	LUSC	ICGC	VCSTT	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.2778
p.L525M	TCGA-A5-A1OF	UCEC	TCGA	VCSTT	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.2778
p.L525M	DO42568	UCEC	ICGC	VCSTT	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.2778
p.R530Q	TCGA-A5-A2K5	UCEC	TCGA	VCSTT	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.1389
p.R530Q	TCGA-AA-A00N	COAD	TCGA	VCSTT	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.1389
p.R530Q	DO9876	COAD	ICGC	VCSTT	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.1389
p.R530Q	DO41379	UCEC	ICGC	VCSTT	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.1389
p.G1598C	TCGA-AA-A02O	COAD	TCGA	PTTSS	DEG_SPOP_SBC_1	1590:1594	Mutation rewiring degron network	0.2222
p.S1679G	TCGA-BR-6452	STAD	TCGA	LKENS	DEG_APCC_KENBOX_2	1669:1673	Mutation blocking phosphorylation signal	0.6111
p.L1669P	TCGA-BR-8589	STAD	TCGA	LKENS	DEG_APCC_KENBOX_2	1669:1673	Mutation altering degron motif	0.6471
p.R1588H	TCGA-BW-A5NP	LIHC	TCGA	PTTSS	DEG_SPOP_SBC_1	1590:1594	Mutation rewiring degron network	0.2778
p.R1588H	TCGA-GR-A4D9	DLBC	TCGA	PTTSS	DEG_SPOP_SBC_1	1590:1594	Mutation rewiring degron network	0.2778
p.R1588L	TCGA-CV-6962	HNSC	TCGA	PTTSS	DEG_SPOP_SBC_1	1590:1594	Mutation rewiring degron network	0.2778
p.R1588S	TCGA-GN-A265	SKCM	TCGA	PTTSS	DEG_SPOP_SBC_1	1590:1594	Mutation rewiring degron network	0.2778
p.A1674S	TCGA-XU-A92Q	THYM	TCGA	LKENS	DEG_APCC_KENBOX_2	1669:1673	Mutation rewiring degron network	0.3056
p.A1678T	DO49929	CESC	ICGC	LKENS	DEG_APCC_KENBOX_2	1669:1673	Mutation rewiring degron network	0.1944
p.S1672N	DO223732	CESC	ICGC	LKENS	DEG_APCC_KENBOX_2	1669:1673	Mutation altering degron motif	0.7069
p.A1669D	DO229019	LICA	ICGC	LKENS	DEG_APCC_KENBOX_2	1669:1673	Mutation altering degron motif	0.7793
p.Q1591K	DO229015	LICA	ICGC	PTTSS	DEG_SPOP_SBC_1	1590:1594	Mutation altering degron motif	0.6944
p.L1667I	DO229027	LICA	ICGC	LKENS	DEG_APCC_KENBOX_2	1669:1673	Mutation rewiring degron network	0.2778
p.H527N	DO229037	LICA	ICGC	VCSTT	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.2222
p.H1600N	DO229045	LICA	ICGC	PTTSS	DEG_SPOP_SBC_1	1590:1594	Mutation rewiring degron network	0.1667
p.S1581C	DO24830	LUAD	ICGC	PTTSS	DEG_SPOP_SBC_1	1590:1594	Mutation rewiring degron network	0.0833
p.G1680E	DO222843	MELA	ICGC	LKENS	DEG_APCC_KENBOX_2	1669:1673	Mutation rewiring degron network	0.1389
p.T1592M	DO232761	PBCA	ICGC	PTTSS	DEG_SPOP_SBC_1	1590:1594	Mutation altering degron motif	0.7423
p.S1585L	DO37896	SKCM	ICGC	PTTSS	DEG_SPOP_SBC_1	1590:1594	Mutation rewiring degron network	0.1944
p.D1586N	DO50284	SKCM	ICGC	PTTSS	DEG_SPOP_SBC_1	1590:1594	Mutation rewiring degron network	0.2222
p.S1604L	DO43306	UCEC	ICGC	PTTSS	DEG_SPOP_SBC_1	1590:1594	Mutation rewiring degron network	0.0556
p.K1670R	SIDM00660	Colorectal Carcinoma	GDSC	LKENS	DEG_APCC_KENBOX_2	1669:1673	Mutation altering degron motif	0.7237
p.K1670R	ACH-000985	Colon/Colorectal Cancer	CCLE	LKENS	DEG_APCC_KENBOX_2	1669:1673	Mutation altering degron motif	0.7237
p.K1670R	LS-411N	large intestine	COSMIC	LKENS	DEG_APCC_KENBOX_2	1669:1673	Mutation altering degron motif	0.7237
p.R1588C	SIDM01154	T-Lymphoblastic Leukemia	GDSC	PTTSS	DEG_SPOP_SBC_1	1590:1594	Mutation rewiring degron network	0.2778
p.R1588C	ACH-000953	Leukemia	CCLE	PTTSS	DEG_SPOP_SBC_1	1590:1594	Mutation rewiring degron network	0.2778
p.R1588C	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	PTTSS	DEG_SPOP_SBC_1	1590:1594	Mutation rewiring degron network	0.2778
p.A1676T	SIDM00887	Other Solid Cancers	GDSC	LKENS	DEG_APCC_KENBOX_2	1669:1673	Mutation rewiring degron network	0.25
p.A1676T	ACH-000211	Brain Cancer	CCLE	LKENS	DEG_APCC_KENBOX_2	1669:1673	Mutation rewiring degron network	0.25
p.A1676T	Daoy	central nervous system	COSMIC	LKENS	DEG_APCC_KENBOX_2	1669:1673	Mutation rewiring degron network	0.25
p.P1664Q	NCI-H1755	lung	COSMIC	LKENS	DEG_APCC_KENBOX_2	1669:1673	Mutation rewiring degron network	0.1944
p.S1599F	NCI-H847	lung	COSMIC	PTTSS	DEG_SPOP_SBC_1	1590:1594	Mutation rewiring degron network	0.1944
p.D1594E	COLO-741	large intestine	COSMIC	PTTSS	DEG_SPOP_SBC_1	1590:1594	Mutation altering degron motif	0.6758
p.D1581E	COLO-741	large intestine	COSMIC	PTTSS	DEG_SPOP_SBC_1	1590:1594	Mutation rewiring degron network	0.0833
p.S1600L	NCI-H847	lung	COSMIC	PTTSS	DEG_SPOP_SBC_1	1590:1594	Mutation rewiring degron network	0.1667
p.P1677Q	NCI-H1755	lung	COSMIC	LKENS	DEG_APCC_KENBOX_2	1669:1673	Mutation substituting flanking lysine	0.3333
p.N1680D	LAMA-84	haematopoietic and lymphoid tissue	COSMIC	LKENS	DEG_APCC_KENBOX_2	1669:1673	Mutation rewiring degron network	0.1389
p.D1669E	COLO-741	large intestine	COSMIC	LKENS	DEG_APCC_KENBOX_2	1669:1673	Mutation altering degron motif	0.6758
p.D1669H	NCI-H2342	lung	COSMIC	LKENS	DEG_APCC_KENBOX_2	1669:1673	Mutation altering degron motif	0.7688
p.D1581H	NCI-H2342	lung	COSMIC	PTTSS	DEG_SPOP_SBC_1	1590:1594	Mutation rewiring degron network	0.0833
p.D1594H	NCI-H2342	lung	COSMIC	PTTSS	DEG_SPOP_SBC_1	1590:1594	Mutation altering degron motif	0.7688
p.L1604S	SNU-1040	large intestine	COSMIC	PTTSS	DEG_SPOP_SBC_1	1590:1594	Mutation rewiring degron network	0.0556

Kaplan plot for KIF13A in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KIF13A

UniProt ID: Q9H1H9

Entrez ID: 63971

Protein name: Kinesin-like protein KIF13A (Kinesin-like protein RBKIN)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KIF13A in