DegronMD

Uniprot ID: Q9H1H9

Source protein: Kinesin-like protein KIF13A

Source gene: KIF13A

Class: DEG_APCC_KENBOX_2

Location: 1669:1673

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9972

ASA_SCORE: 98.6

COIL: 0.7088

CONS_SCORE: 0.2519

DSS_SCORE: 0.3709

HELIX: 0.2446

FCONS_SCORE: 1.0745

RIG_SCORE: 0.7855

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1679G	TCGA-BR-6452	STAD	TCGA	LKENS	DEG_APCC_KENBOX_2	0.6111
p.L1669P	TCGA-BR-8589	STAD	TCGA	LKENS	DEG_APCC_KENBOX_2	0.6471
p.A1674S	TCGA-XU-A92Q	THYM	TCGA	LKENS	DEG_APCC_KENBOX_2	0.3056
p.A1678T	DO49929	CESC	ICGC	LKENS	DEG_APCC_KENBOX_2	0.1944
p.S1672N	DO223732	CESC	ICGC	LKENS	DEG_APCC_KENBOX_2	0.7069
p.A1669D	DO229019	LICA	ICGC	LKENS	DEG_APCC_KENBOX_2	0.7793
p.L1667I	DO229027	LICA	ICGC	LKENS	DEG_APCC_KENBOX_2	0.2778
p.G1680E	DO222843	MELA	ICGC	LKENS	DEG_APCC_KENBOX_2	0.1389
p.K1670R	SIDM00660	Colorectal Carcinoma	GDSC	LKENS	DEG_APCC_KENBOX_2	0.7237
p.K1670R	ACH-000985	Colon/Colorectal Cancer	CCLE	LKENS	DEG_APCC_KENBOX_2	0.7237
p.K1670R	LS-411N	large_intestine	COSMIC	LKENS	DEG_APCC_KENBOX_2	0.7237
p.A1676T	SIDM00887	Other Solid Cancers	GDSC	LKENS	DEG_APCC_KENBOX_2	0.25
p.A1676T	ACH-000211	Brain Cancer	CCLE	LKENS	DEG_APCC_KENBOX_2	0.25
p.A1676T	Daoy	central_nervous_system	COSMIC	LKENS	DEG_APCC_KENBOX_2	0.25
p.P1664Q	NCI-H1755	lung	COSMIC	LKENS	DEG_APCC_KENBOX_2	0.1944
p.P1677Q	NCI-H1755	lung	COSMIC	LKENS	DEG_APCC_KENBOX_2	0.3333
p.N1680D	LAMA-84	haematopoietic_and_lymphoid_tissue	COSMIC	LKENS	DEG_APCC_KENBOX_2	0.1389
p.D1669E	COLO-741	large_intestine	COSMIC	LKENS	DEG_APCC_KENBOX_2	0.6758
p.D1669H	NCI-H2342	lung	COSMIC	LKENS	DEG_APCC_KENBOX_2	0.7688

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P28289	Tropomodulin-1	DEG_APCC_KENBOX_2	220:224	LKENS	APC,CDC20,FZR1	0.5457	More...
Q8TBJ5	Fez family zinc finger protein 2	DEG_APCC_KENBOX_2	246:250	LKENS	APC,CDC20,FZR1	0.938	More...
Q8TF72	Protein Shroom3	DEG_APCC_KENBOX_2	1710:1714	LKENS	APC,CDC20,FZR1	0.735	More...
Q9H1H9	Kinesin-like protein KIF13A	DEG_APCC_KENBOX_2	1669:1673	LKENS	APC,CDC20,FZR1	0.9972	More...
A7XYQ1	Sine oculis-binding protein homolog	DEG_APCC_KENBOX_2	77:81	LKENS	APC,CDC20,FZR1	0.9117	More...
Q5THK1	Protein PRR14L	DEG_APCC_KENBOX_2	336:340	LKENS	APC,CDC20,FZR1	0.998	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons