FEZF2
UniProt ID: Q8TBJ5
Entrez ID: 55079
Protein name: Fez family zinc finger protein 2 (Forebrain embryonic zinc finger-like protein 2) (Zinc finger protein 312) (Zinc finger protein Fez-like)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Transcription repressor. Required for the specification of corticospinal motor neurons and other subcerebral projection neurons. May play a role in layer and neuronal subtype-specific patterning of subcortical projections and axonal fasciculation. Controls the development of dendritic arbo...
FUNCTION: Transcription repressor. Required for the specification of corticospinal motor neurons and other subcerebral projection neurons. May play a role in layer and neuronal subtype-specific patterning of subcortical projections and axonal fasciculation. Controls the development of dendritic arborization and spines of large layer V pyramidal neurons. May be involved in innate immunity (By similarity). {ECO:0000250}.
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GO - Biological processes (BP):
axonal fasciculation [GO:0007413]; cell dedifferentiation [GO:0043697]; cerebral cortex GABAergic interneuron migration [GO:0021853]; commitment of neuronal cell to specific neuron type in forebrain [GO:0021902]; dendrite development [GO:0016358]; dentate gyrus development [GO:0021542]; forebrain an...
axonal fasciculation [GO:0007413]; cell dedifferentiation [GO:0043697]; cerebral cortex GABAergic interneuron migration [GO:0021853]; commitment of neuronal cell to specific neuron type in forebrain [GO:0021902]; dendrite development [GO:0016358]; dentate gyrus development [GO:0021542]; forebrain anterior/posterior pattern specification [GO:0021797]; locomotory behavior [GO:0007626]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of neuron differentiation [GO:0045665]; neuron fate determination [GO:0048664]; positive regulation of neuron differentiation [GO:0045666]; regulation of axon guidance [GO:1902667]; regulation of gene expression [GO:0010468]; regulation of neurogenesis [GO:0050767]
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GO - Molecular function (MF):
chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA ...
chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]
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GO - Cellular component (CC):
nucleus [GO:0005634]...
nucleus [GO:0005634]
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FEZF2
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Kaplan plot for FEZF2 in
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*NOTE: the Kaplan plots were collected from OncoLnc