DegronMD

Uniprot ID: Q8TBJ5

Source protein: Fez family zinc finger protein 2

Source gene: FEZF2

Class: DEG_APCC_KENBOX_2

Location: 246:250

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.938

ASA_SCORE: 67.48

COIL: 0.5322

CONS_SCORE: 0.4729

DSS_SCORE: 0.5471

HELIX: 0.426

FCONS_SCORE: 1.1919

RIG_SCORE: 0.7418

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A251P	TCGA-25-1314	OV	TCGA	LKENS	DEG_APCC_KENBOX_2	0.3056
p.A251P	DO29338	OV	ICGC	LKENS	DEG_APCC_KENBOX_2	0.3056
p.A251T	TCGA-B5-A3FC	UCEC	TCGA	LKENS	DEG_APCC_KENBOX_2	0.3056
p.A251T	DO41871	UCEC	ICGC	LKENS	DEG_APCC_KENBOX_2	0.3056
p.P239R	TCGA-CG-4476	STAD	TCGA	LKENS	DEG_APCC_KENBOX_2	0.1389
p.P239R	DO38276	STAD	ICGC	LKENS	DEG_APCC_KENBOX_2	0.1389
p.E248K	TCGA-EE-A29S	SKCM	TCGA	LKENS	DEG_APCC_KENBOX_2	0.7022
p.E248K	DO37936	SKCM	ICGC	LKENS	DEG_APCC_KENBOX_2	0.7022
p.G257E	TCGA-JX-A3Q0	CESC	TCGA	LKENS	DEG_APCC_KENBOX_2	0.1389
p.G257E	DO51607	CESC	ICGC	LKENS	DEG_APCC_KENBOX_2	0.1389
p.R237H	DO228904	LICA	ICGC	LKENS	DEG_APCC_KENBOX_2	0.0833
p.R237C	SIDM02039	Colorectal Carcinoma	GDSC	LKENS	DEG_APCC_KENBOX_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P28289	Tropomodulin-1	DEG_APCC_KENBOX_2	220:224	LKENS	APC,CDC20,FZR1	0.5457	More...
Q8TBJ5	Fez family zinc finger protein 2	DEG_APCC_KENBOX_2	246:250	LKENS	APC,CDC20,FZR1	0.938	More...
Q8TF72	Protein Shroom3	DEG_APCC_KENBOX_2	1710:1714	LKENS	APC,CDC20,FZR1	0.735	More...
Q9H1H9	Kinesin-like protein KIF13A	DEG_APCC_KENBOX_2	1669:1673	LKENS	APC,CDC20,FZR1	0.9972	More...
A7XYQ1	Sine oculis-binding protein homolog	DEG_APCC_KENBOX_2	77:81	LKENS	APC,CDC20,FZR1	0.9117	More...
Q5THK1	Protein PRR14L	DEG_APCC_KENBOX_2	336:340	LKENS	APC,CDC20,FZR1	0.998	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons