DegronMD

Uniprot ID: Q5THK1

Source protein: Protein PRR14L

Source gene: PRR14L

Class: DEG_APCC_KENBOX_2

Location: 336:340

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.998

ASA_SCORE: 104.58

COIL: 0.7978

CONS_SCORE: 0.6271

DSS_SCORE: 0.5819

HELIX: 0.157

FCONS_SCORE: 1.2733

RIG_SCORE: 0.6488

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N339D	DO7801	COAD	ICGC	LKENS	DEG_APCC_KENBOX_2	0.6932
p.T326K	DO229028	LICA	ICGC	LKENS	DEG_APCC_KENBOX_2	0.0556
p.T331I	SIDM01133	Other Solid Cancers	GDSC	LKENS	DEG_APCC_KENBOX_2	0.1944
p.T331I	ACH-002177	Lung Cancer	CCLE	LKENS	DEG_APCC_KENBOX_2	0.1944
p.T331I	NCI-H835	lung	COSMIC	LKENS	DEG_APCC_KENBOX_2	0.1944
p.E341K	ACH-000554	Breast Cancer	CCLE	LKENS	DEG_APCC_KENBOX_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P28289	Tropomodulin-1	DEG_APCC_KENBOX_2	220:224	LKENS	APC,CDC20,FZR1	0.5457	More...
Q8TBJ5	Fez family zinc finger protein 2	DEG_APCC_KENBOX_2	246:250	LKENS	APC,CDC20,FZR1	0.938	More...
Q8TF72	Protein Shroom3	DEG_APCC_KENBOX_2	1710:1714	LKENS	APC,CDC20,FZR1	0.735	More...
Q9H1H9	Kinesin-like protein KIF13A	DEG_APCC_KENBOX_2	1669:1673	LKENS	APC,CDC20,FZR1	0.9972	More...
A7XYQ1	Sine oculis-binding protein homolog	DEG_APCC_KENBOX_2	77:81	LKENS	APC,CDC20,FZR1	0.9117	More...
Q5THK1	Protein PRR14L	DEG_APCC_KENBOX_2	336:340	LKENS	APC,CDC20,FZR1	0.998	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons