DegronMD - Q8TF72(SHROOM3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V1343F	TCGA-17-Z051	LUAD	TCGA	PLTPIGT	DEG_SCF_FBW7_1	1350:1356	Mutation rewiring degron network	0.1389
p.R1901W	TCGA-39-5034	LUSC	TCGA	LKENL	DEG_APCC_KENBOX_2	1894:1898	Mutation rewiring degron network	0.25
p.R1901W	DO26854	LUSC	ICGC	LKENL	DEG_APCC_KENBOX_2	1894:1898	Mutation rewiring degron network	0.25
p.E827Q	TCGA-3C-AALI	BRCA	TCGA	VSTSS	DEG_SPOP_SBC_1	815:819	Mutation rewiring degron network	0.1111
p.E827Q	DO219589	BRCA	ICGC	VSTSS	DEG_SPOP_SBC_1	815:819	Mutation rewiring degron network	0.1111
p.P471L	TCGA-3N-A9WD	SKCM	TCGA	TSIYPVPSL	DEG_COP1_1	465:473	Mutation altering degron motif	0.7582
p.P471L	DO51235	SKCM	ICGC	TSIYPVPSL	DEG_COP1_1	465:473	Mutation altering degron motif	0.7582
p.R1722I	TCGA-77-6842	LUSC	TCGA	LKENS	DEG_APCC_KENBOX_2	1710:1714	Mutation rewiring degron network	0.1111
p.R1722I	DO27413	LUSC	ICGC	LKENS	DEG_APCC_KENBOX_2	1710:1714	Mutation rewiring degron network	0.1111
p.G1701C	TCGA-85-8664	LUSC	TCGA	LKENS	DEG_APCC_KENBOX_2	1710:1714	Mutation rewiring degron network	0.0833
p.G1701C	DO45469	LUSC	ICGC	LKENS	DEG_APCC_KENBOX_2	1710:1714	Mutation rewiring degron network	0.0833
p.Q1887H	TCGA-A5-A0G2	UCEC	TCGA	LKENL	DEG_APCC_KENBOX_2	1894:1898	Mutation rewiring degron network	0.1389
p.Q1887H	DO41235	UCEC	ICGC	LKENL	DEG_APCC_KENBOX_2	1894:1898	Mutation rewiring degron network	0.1389
p.E474Q	TCGA-AC-A23H	BRCA	TCGA	TSIYPVPSL	DEG_COP1_1	465:473	Mutation rewiring degron network	0.3056
p.E474Q	DO2401	BRCA	ICGC	TSIYPVPSL	DEG_COP1_1	465:473	Mutation rewiring degron network	0.3056
p.D1706Y	TCGA-AJ-A3EL	UCEC	TCGA	LKENS	DEG_APCC_KENBOX_2	1710:1714	Mutation rewiring degron network	0.2222
p.D1706Y	DO41542	UCEC	ICGC	LKENS	DEG_APCC_KENBOX_2	1710:1714	Mutation rewiring degron network	0.2222
p.T817A	TCGA-AP-A0LG	UCEC	TCGA	VSTSS	DEG_SPOP_SBC_1	815:819	Mutation altering degron motif	0.825
p.T817A	DO41823	UCEC	ICGC	VSTSS	DEG_SPOP_SBC_1	815:819	Mutation altering degron motif	0.825
p.E826K	TCGA-AX-A2HC	UCEC	TCGA	VSTSS	DEG_SPOP_SBC_1	815:819	Mutation rewiring degron network	0.1389
p.E826K	DO41572	UCEC	ICGC	VSTSS	DEG_SPOP_SBC_1	815:819	Mutation rewiring degron network	0.1389
p.Y809F	TCGA-BJ-A0Z0	THCA	TCGA	VSTSS	DEG_SPOP_SBC_1	815:819	Mutation rewiring degron network	0.1667
p.Y809F	DO39276	THCA	ICGC	VSTSS	DEG_SPOP_SBC_1	815:819	Mutation rewiring degron network	0.1667
p.G1907D	TCGA-BR-8680	STAD	TCGA	LKENL	DEG_APCC_KENBOX_2	1894:1898	Mutation rewiring degron network	0.0833
p.G1907D	DO47769	STAD	ICGC	LKENL	DEG_APCC_KENBOX_2	1894:1898	Mutation rewiring degron network	0.0833
p.F825L	TCGA-BS-A0UJ	UCEC	TCGA	VSTSS	DEG_SPOP_SBC_1	815:819	Mutation rewiring degron network	0.1667
p.F825L	DO42745	UCEC	ICGC	VSTSS	DEG_SPOP_SBC_1	815:819	Mutation rewiring degron network	0.1667
p.R1900C	TCGA-CA-6717	COAD	TCGA	LKENL	DEG_APCC_KENBOX_2	1894:1898	Mutation rewiring degron network	0.2778
p.R1900C	DO8264	COAD	ICGC	LKENL	DEG_APCC_KENBOX_2	1894:1898	Mutation rewiring degron network	0.2778
p.R1892W	TCGA-DC-5869	READ	TCGA	LKENL	DEG_APCC_KENBOX_2	1894:1898	Mutation rewiring degron network	0.2778
p.R1892W	DO36584	READ	ICGC	LKENL	DEG_APCC_KENBOX_2	1894:1898	Mutation rewiring degron network	0.2778
p.L1898M	TCGA-DX-AB2W	SARC	TCGA	LKENL	DEG_APCC_KENBOX_2	1894:1898	Mutation altering degron motif	0.5999
p.L1898M	DO220095	SARC	ICGC	LKENL	DEG_APCC_KENBOX_2	1894:1898	Mutation altering degron motif	0.5999
p.P1704L	TCGA-EB-A3XF	SKCM	TCGA	LKENS	DEG_APCC_KENBOX_2	1710:1714	Mutation rewiring degron network	0.1667
p.P1704L	DO37437	SKCM	ICGC	LKENS	DEG_APCC_KENBOX_2	1710:1714	Mutation rewiring degron network	0.1667
p.P1704L	SIDM00145	T-Lymphoblastic Leukemia	GDSC	LKENS	DEG_APCC_KENBOX_2	1710:1714	Mutation rewiring degron network	0.1667
p.P1704L	ACH-001127	Leukemia	CCLE	LKENS	DEG_APCC_KENBOX_2	1710:1714	Mutation rewiring degron network	0.1667
p.P1704L	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	LKENS	DEG_APCC_KENBOX_2	1710:1714	Mutation rewiring degron network	0.1667
p.H812N	TCGA-EC-A24G	UCEC	TCGA	VSTSS	DEG_SPOP_SBC_1	815:819	Mutation rewiring degron network	0.25
p.H812N	DO40996	UCEC	ICGC	VSTSS	DEG_SPOP_SBC_1	815:819	Mutation rewiring degron network	0.25
p.P811A	TCGA-LL-A6FP	BRCA	TCGA	VSTSS	DEG_SPOP_SBC_1	815:819	Mutation rewiring degron network	0.2222
p.P811A	DO51212	BRCA	ICGC	VSTSS	DEG_SPOP_SBC_1	815:819	Mutation rewiring degron network	0.2222
p.G1886V	TCGA-P6-A5OG	ACC	TCGA	LKENL	DEG_APCC_KENBOX_2	1894:1898	Mutation rewiring degron network	0.1111
p.G1886V	DO228952	LICA	ICGC	LKENL	DEG_APCC_KENBOX_2	1894:1898	Mutation rewiring degron network	0.1111
p.A478S	TCGA-VS-A9V5	CESC	TCGA	TSIYPVPSL	DEG_COP1_1	465:473	Mutation rewiring degron network	0.1944
p.A478S	DO51650	CESC	ICGC	TSIYPVPSL	DEG_COP1_1	465:473	Mutation rewiring degron network	0.1944
p.P469A	DO230334	COCA	ICGC	TSIYPVPSL	DEG_COP1_1	465:473	Mutation altering degron motif	0.6392
p.P469A	DO229010	COCA	ICGC	TSIYPVPSL	DEG_COP1_1	465:473	Mutation altering degron motif	0.6392
p.P469A	DO230659	LAML	ICGC	TSIYPVPSL	DEG_COP1_1	465:473	Mutation altering degron motif	0.6392
p.P469A	DO231140	LAML	ICGC	TSIYPVPSL	DEG_COP1_1	465:473	Mutation altering degron motif	0.6392
p.P469A	DO228941	LICA	ICGC	TSIYPVPSL	DEG_COP1_1	465:473	Mutation altering degron motif	0.6392
p.P469A	DO230545	LUSC	ICGC	TSIYPVPSL	DEG_COP1_1	465:473	Mutation altering degron motif	0.6392
p.P469A	DO231207	LUSC	ICGC	TSIYPVPSL	DEG_COP1_1	465:473	Mutation altering degron motif	0.6392
p.P469L	DO52676	MALY	ICGC	TSIYPVPSL	DEG_COP1_1	465:473	Mutation altering degron motif	0.6471
p.E1896Q	DO47156	RECA	ICGC	LKENL	DEG_APCC_KENBOX_2	1894:1898	Mutation altering degron motif	0.6744
p.R1705Q	SIDM00334	Endometrial Carcinoma	GDSC	LKENS	DEG_APCC_KENBOX_2	1710:1714	Mutation rewiring degron network	0.1944
p.R1705Q	ACH-000879	Endometrial/Uterine Cancer	CCLE	LKENS	DEG_APCC_KENBOX_2	1710:1714	Mutation rewiring degron network	0.1944
p.R1705Q	MFE-296	endometrium	COSMIC	LKENS	DEG_APCC_KENBOX_2	1710:1714	Mutation rewiring degron network	0.1944
p.R1900H	SIDM00216	Colorectal Carcinoma	GDSC	LKENL	DEG_APCC_KENBOX_2	1894:1898	Mutation rewiring degron network	0.2778
p.R1900H	ACH-000989	Colon/Colorectal Cancer	CCLE	LKENL	DEG_APCC_KENBOX_2	1894:1898	Mutation rewiring degron network	0.2778
p.R1900H	SNU-175	large intestine	COSMIC	LKENL	DEG_APCC_KENBOX_2	1894:1898	Mutation rewiring degron network	0.2778
p.T1352I	SIDM00516	Melanoma	GDSC	PLTPIGT	DEG_SCF_FBW7_1	1350:1356	Mutation altering degron motif	0.8189
p.T1352I	ACH-002166	Skin Cancer	CCLE	PLTPIGT	DEG_SCF_FBW7_1	1350:1356	Mutation altering degron motif	0.8189
p.T1352I	MZ7-mel	skin	COSMIC	PLTPIGT	DEG_SCF_FBW7_1	1350:1356	Mutation altering degron motif	0.8189
p.R1722S	SIDM00940	Breast Carcinoma	GDSC	LKENS	DEG_APCC_KENBOX_2	1710:1714	Mutation rewiring degron network	0.1111
p.R1722S	ACH-000212	Breast Cancer	CCLE	LKENS	DEG_APCC_KENBOX_2	1710:1714	Mutation rewiring degron network	0.1111
p.R1722S	CAL-120	breast	COSMIC	LKENS	DEG_APCC_KENBOX_2	1710:1714	Mutation rewiring degron network	0.1111
p.V480M	ACH-000185	Non-Cancerous	CCLE	TSIYPVPSL	DEG_COP1_1	465:473	Mutation rewiring degron network	0.1389
p.P1353T	ACH-001367	Neuroblastoma	CCLE	PLTPIGT	DEG_SCF_FBW7_1	1350:1356	Mutation altering degron motif	0.7031
p.Q457K	ACH-001518	Endometrial/Uterine Cancer	CCLE	TSIYPVPSL	DEG_COP1_1	465:473	Mutation rewiring degron network	0.1111
p.V815I	ACH-001699	Head and Neck Cancer	CCLE	VSTSS	DEG_SPOP_SBC_1	815:819	Mutation altering degron motif	0.7076
p.P817S	NCI-H650	lung	COSMIC	VSTSS	DEG_SPOP_SBC_1	815:819	Mutation altering degron motif	0.6752
p.E1704K	NCI-H2347	lung	COSMIC	LKENS	DEG_APCC_KENBOX_2	1710:1714	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SHROOM3

UniProt ID: Q8TF72

Entrez ID: 57619

Protein name: Protein Shroom3 (Shroom-related protein) (hShrmL)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SHROOM3 in