DegronMD

Uniprot ID: Q8TF72

Source protein: Protein Shroom3

Source gene: SHROOM3

Class: DEG_SCF_FBW7_1

Location: 1350:1356

E3 ligase: FBXW7

DEGRON score: 0.9909

ASA_SCORE: 83.5429

COIL: 0.9583

CONS_SCORE: 0.2761

DSS_SCORE: 0.5875

HELIX: 0.0127

FCONS_SCORE: 0.8961

RIG_SCORE: 0.6989

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V1343F	TCGA-17-Z051	LUAD	TCGA	PLTPIGT	DEG_SCF_FBW7_1	0.1389
p.T1352I	SIDM00516	Melanoma	GDSC	PLTPIGT	DEG_SCF_FBW7_1	0.8189
p.T1352I	ACH-002166	Skin Cancer	CCLE	PLTPIGT	DEG_SCF_FBW7_1	0.8189
p.T1352I	MZ7-mel	skin	COSMIC	PLTPIGT	DEG_SCF_FBW7_1	0.8189
p.P1353T	ACH-001367	Neuroblastoma	CCLE	PLTPIGT	DEG_SCF_FBW7_1	0.7031

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TF72	Protein Shroom3	DEG_SCF_FBW7_1	1350:1356	PLTPIGT	FBXW7	0.9909	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons