DegronMD

Uniprot ID: Q8TF72

Source protein: Protein Shroom3

Source gene: SHROOM3

Class: DEG_COP1_1

Location: 465:473

E3 ligase: COP1

DEGRON score: 0.8308

ASA_SCORE: 88.9333

COIL: 0.9238

CONS_SCORE: 0.3145

DSS_SCORE: 0.4856

HELIX: 0.0232

FCONS_SCORE: 0.8001

RIG_SCORE: 0.7066

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P471L	TCGA-3N-A9WD	SKCM	TCGA	TSIYPVPSL	DEG_COP1_1	0.7582
p.P471L	DO51235	SKCM	ICGC	TSIYPVPSL	DEG_COP1_1	0.7582
p.E474Q	TCGA-AC-A23H	BRCA	TCGA	TSIYPVPSL	DEG_COP1_1	0.3056
p.E474Q	DO2401	BRCA	ICGC	TSIYPVPSL	DEG_COP1_1	0.3056
p.A478S	TCGA-VS-A9V5	CESC	TCGA	TSIYPVPSL	DEG_COP1_1	0.1944
p.A478S	DO51650	CESC	ICGC	TSIYPVPSL	DEG_COP1_1	0.1944
p.P469A	DO230334	COCA	ICGC	TSIYPVPSL	DEG_COP1_1	0.6392
p.P469A	DO229010	COCA	ICGC	TSIYPVPSL	DEG_COP1_1	0.6392
p.P469A	DO230659	LAML	ICGC	TSIYPVPSL	DEG_COP1_1	0.6392
p.P469A	DO231140	LAML	ICGC	TSIYPVPSL	DEG_COP1_1	0.6392
p.P469A	DO228941	LICA	ICGC	TSIYPVPSL	DEG_COP1_1	0.6392
p.P469A	DO230545	LUSC	ICGC	TSIYPVPSL	DEG_COP1_1	0.6392
p.P469A	DO231207	LUSC	ICGC	TSIYPVPSL	DEG_COP1_1	0.6392
p.P469L	DO52676	MALY	ICGC	TSIYPVPSL	DEG_COP1_1	0.6471
p.V480M	ACH-000185	Non-Cancerous	CCLE	TSIYPVPSL	DEG_COP1_1	0.1389
p.Q457K	ACH-001518	Endometrial/Uterine Cancer	CCLE	TSIYPVPSL	DEG_COP1_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TF72	Protein Shroom3	DEG_COP1_1	465:473	TSIYPVPSL	COP1	0.8308	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons