DegronMD

Uniprot ID: Q8TF72

Source protein: Protein Shroom3

Source gene: SHROOM3

Class: DEG_APCC_KENBOX_2

Location: 1710:1714

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.735

ASA_SCORE: 99.54

COIL: 0.5946

CONS_SCORE: 0.2183

DSS_SCORE: 0.3396

HELIX: 0.4002

FCONS_SCORE: 0.6173

RIG_SCORE: 0.7787

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1722I	TCGA-77-6842	LUSC	TCGA	LKENS	DEG_APCC_KENBOX_2	0.1111
p.R1722I	DO27413	LUSC	ICGC	LKENS	DEG_APCC_KENBOX_2	0.1111
p.G1701C	TCGA-85-8664	LUSC	TCGA	LKENS	DEG_APCC_KENBOX_2	0.0833
p.G1701C	DO45469	LUSC	ICGC	LKENS	DEG_APCC_KENBOX_2	0.0833
p.D1706Y	TCGA-AJ-A3EL	UCEC	TCGA	LKENS	DEG_APCC_KENBOX_2	0.2222
p.D1706Y	DO41542	UCEC	ICGC	LKENS	DEG_APCC_KENBOX_2	0.2222
p.P1704L	TCGA-EB-A3XF	SKCM	TCGA	LKENS	DEG_APCC_KENBOX_2	0.1667
p.P1704L	DO37437	SKCM	ICGC	LKENS	DEG_APCC_KENBOX_2	0.1667
p.P1704L	SIDM00145	T-Lymphoblastic Leukemia	GDSC	LKENS	DEG_APCC_KENBOX_2	0.1667
p.P1704L	ACH-001127	Leukemia	CCLE	LKENS	DEG_APCC_KENBOX_2	0.1667
p.P1704L	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	LKENS	DEG_APCC_KENBOX_2	0.1667
p.R1705Q	SIDM00334	Endometrial Carcinoma	GDSC	LKENS	DEG_APCC_KENBOX_2	0.1944
p.R1705Q	ACH-000879	Endometrial/Uterine Cancer	CCLE	LKENS	DEG_APCC_KENBOX_2	0.1944
p.R1705Q	MFE-296	endometrium	COSMIC	LKENS	DEG_APCC_KENBOX_2	0.1944
p.R1722S	SIDM00940	Breast Carcinoma	GDSC	LKENS	DEG_APCC_KENBOX_2	0.1111
p.R1722S	ACH-000212	Breast Cancer	CCLE	LKENS	DEG_APCC_KENBOX_2	0.1111
p.R1722S	CAL-120	breast	COSMIC	LKENS	DEG_APCC_KENBOX_2	0.1111
p.E1704K	NCI-H2347	lung	COSMIC	LKENS	DEG_APCC_KENBOX_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P28289	Tropomodulin-1	DEG_APCC_KENBOX_2	220:224	LKENS	APC,CDC20,FZR1	0.5457	More...
Q8TBJ5	Fez family zinc finger protein 2	DEG_APCC_KENBOX_2	246:250	LKENS	APC,CDC20,FZR1	0.938	More...
Q8TF72	Protein Shroom3	DEG_APCC_KENBOX_2	1710:1714	LKENS	APC,CDC20,FZR1	0.735	More...
Q9H1H9	Kinesin-like protein KIF13A	DEG_APCC_KENBOX_2	1669:1673	LKENS	APC,CDC20,FZR1	0.9972	More...
A7XYQ1	Sine oculis-binding protein homolog	DEG_APCC_KENBOX_2	77:81	LKENS	APC,CDC20,FZR1	0.9117	More...
Q5THK1	Protein PRR14L	DEG_APCC_KENBOX_2	336:340	LKENS	APC,CDC20,FZR1	0.998	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons