DegronMD

Uniprot ID: A7XYQ1

Source protein: Sine oculis-binding protein homolog

Source gene: SOBP

Class: DEG_APCC_KENBOX_2

Location: 77:81

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9117

ASA_SCORE: 99.58

COIL: 0.7372

CONS_SCORE: 0.6162

DSS_SCORE: 0.5413

HELIX: 0.186

FCONS_SCORE: 1.13

RIG_SCORE: 0.7143

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q72R	TCGA-AX-A1C4	UCEC	TCGA	LKENS	DEG_APCC_KENBOX_2	0.1944
p.Q72R	DO42480	UCEC	ICGC	LKENS	DEG_APCC_KENBOX_2	0.1944
p.E69K	TCGA-G9-6369	PRAD	TCGA	LKENS	DEG_APCC_KENBOX_2	0.1111
p.E69K	DO36310	PRAD	ICGC	LKENS	DEG_APCC_KENBOX_2	0.1111
p.D90Y	TCGA-W5-AA2U	CHOL	TCGA	LKENS	DEG_APCC_KENBOX_2	0.0833
p.S81Y	DO7801	COAD	ICGC	LKENS	DEG_APCC_KENBOX_2	0.6009
p.S81Y	SIDM00193	Colorectal Carcinoma	GDSC	LKENS	DEG_APCC_KENBOX_2	0.6009
p.S81Y	ACH-000991	Colon/Colorectal Cancer	CCLE	LKENS	DEG_APCC_KENBOX_2	0.6009
p.S81Y	SNU-81	large_intestine	COSMIC	LKENS	DEG_APCC_KENBOX_2	0.6009
p.L77I	DO8898	COAD	ICGC	LKENS	DEG_APCC_KENBOX_2	0.6063
p.L77R	DO233866	GACA	ICGC	LKENS	DEG_APCC_KENBOX_2	0.7316
p.G68V	DO228976	LICA	ICGC	LKENS	DEG_APCC_KENBOX_2	0.0833
p.R71W	SIDM01779	Gastric Carcinoma	GDSC	LKENS	DEG_APCC_KENBOX_2	0.1667
p.R71W	ACH-000761	Gastric Cancer	CCLE	LKENS	DEG_APCC_KENBOX_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P28289	Tropomodulin-1	DEG_APCC_KENBOX_2	220:224	LKENS	APC,CDC20,FZR1	0.5457	More...
Q8TBJ5	Fez family zinc finger protein 2	DEG_APCC_KENBOX_2	246:250	LKENS	APC,CDC20,FZR1	0.938	More...
Q8TF72	Protein Shroom3	DEG_APCC_KENBOX_2	1710:1714	LKENS	APC,CDC20,FZR1	0.735	More...
Q9H1H9	Kinesin-like protein KIF13A	DEG_APCC_KENBOX_2	1669:1673	LKENS	APC,CDC20,FZR1	0.9972	More...
A7XYQ1	Sine oculis-binding protein homolog	DEG_APCC_KENBOX_2	77:81	LKENS	APC,CDC20,FZR1	0.9117	More...
Q5THK1	Protein PRR14L	DEG_APCC_KENBOX_2	336:340	LKENS	APC,CDC20,FZR1	0.998	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons