DegronMD

Uniprot ID: P28289

Source protein: Tropomodulin-1

Source gene: TMOD1

Class: DEG_APCC_KENBOX_2

Location: 220:224

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5457

ASA_SCORE: 62.28

COIL: 0.6134

CONS_SCORE: 0.5841

DSS_SCORE: 0.1135

HELIX: 0.3934

FCONS_SCORE: 0.991

RIG_SCORE: 0.8069

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K221N	TCGA-AX-A05Z	UCEC	TCGA	LKENS	DEG_APCC_KENBOX_2	0.6918
p.K221N	DO40884	UCEC	ICGC	LKENS	DEG_APCC_KENBOX_2	0.6918
p.L220P	TCGA-HU-A4GT	STAD	TCGA	LKENS	DEG_APCC_KENBOX_2	0.6471
p.L220P	DO48020	STAD	ICGC	LKENS	DEG_APCC_KENBOX_2	0.6471
p.G233V	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	LKENS	DEG_APCC_KENBOX_2	0.0833
p.G233V	ACH-002272	Lymphoma	CCLE	LKENS	DEG_APCC_KENBOX_2	0.0833
p.G233V	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	LKENS	DEG_APCC_KENBOX_2	0.0833
p.V212L	MC-IXC	autonomic_ganglia	COSMIC	LKENS	DEG_APCC_KENBOX_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P28289	Tropomodulin-1	DEG_APCC_KENBOX_2	220:224	LKENS	APC,CDC20,FZR1	0.5457	More...
Q8TBJ5	Fez family zinc finger protein 2	DEG_APCC_KENBOX_2	246:250	LKENS	APC,CDC20,FZR1	0.938	More...
Q8TF72	Protein Shroom3	DEG_APCC_KENBOX_2	1710:1714	LKENS	APC,CDC20,FZR1	0.735	More...
Q9H1H9	Kinesin-like protein KIF13A	DEG_APCC_KENBOX_2	1669:1673	LKENS	APC,CDC20,FZR1	0.9972	More...
A7XYQ1	Sine oculis-binding protein homolog	DEG_APCC_KENBOX_2	77:81	LKENS	APC,CDC20,FZR1	0.9117	More...
Q5THK1	Protein PRR14L	DEG_APCC_KENBOX_2	336:340	LKENS	APC,CDC20,FZR1	0.998	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons