DegronMD - A7XYQ1(SOBP)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A515V	TCGA-A5-A2K7	UCEC	TCGA	LAPLVPPPTLLV	DEG_ODPH_VHL_1	514:525	Mutation altering degron motif	0.6936
p.A515V	TCGA-AP-A1DV	UCEC	TCGA	LAPLVPPPTLLV	DEG_ODPH_VHL_1	514:525	Mutation altering degron motif	0.6936
p.A515V	DO43186	UCEC	ICGC	LAPLVPPPTLLV	DEG_ODPH_VHL_1	514:525	Mutation altering degron motif	0.6936
p.A515V	DO41271	UCEC	ICGC	LAPLVPPPTLLV	DEG_ODPH_VHL_1	514:525	Mutation altering degron motif	0.6936
p.Q72R	TCGA-AX-A1C4	UCEC	TCGA	LKENS	DEG_APCC_KENBOX_2	77:81	Mutation rewiring degron network	0.1944
p.Q72R	DO42480	UCEC	ICGC	LKENS	DEG_APCC_KENBOX_2	77:81	Mutation rewiring degron network	0.1944
p.P526S	TCGA-CG-4460	STAD	TCGA	LAPLVPPPTLLV	DEG_ODPH_VHL_1	514:525	Mutation rewiring degron network	0.3056
p.P526S	DO38427	STAD	ICGC	LAPLVPPPTLLV	DEG_ODPH_VHL_1	514:525	Mutation rewiring degron network	0.3056
p.P521S	TCGA-EE-A2MR	SKCM	TCGA	LAPLVPPPTLLV	DEG_ODPH_VHL_1	514:525	Mutation altering degron motif	0.5641
p.P521S	DO37819	SKCM	ICGC	LAPLVPPPTLLV	DEG_ODPH_VHL_1	514:525	Mutation altering degron motif	0.5641
p.E69K	TCGA-G9-6369	PRAD	TCGA	LKENS	DEG_APCC_KENBOX_2	77:81	Mutation rewiring degron network	0.1111
p.E69K	DO36310	PRAD	ICGC	LKENS	DEG_APCC_KENBOX_2	77:81	Mutation rewiring degron network	0.1111
p.D90Y	TCGA-W5-AA2U	CHOL	TCGA	LKENS	DEG_APCC_KENBOX_2	77:81	Mutation rewiring degron network	0.0833
p.S81Y	DO7801	COAD	ICGC	LKENS	DEG_APCC_KENBOX_2	77:81	Mutation altering degron motif	0.6009
p.S81Y	SIDM00193	Colorectal Carcinoma	GDSC	LKENS	DEG_APCC_KENBOX_2	77:81	Mutation altering degron motif	0.6009
p.S81Y	ACH-000991	Colon/Colorectal Cancer	CCLE	LKENS	DEG_APCC_KENBOX_2	77:81	Mutation altering degron motif	0.6009
p.S81Y	SNU-81	large intestine	COSMIC	LKENS	DEG_APCC_KENBOX_2	77:81	Mutation altering degron motif	0.6009
p.L77I	DO8898	COAD	ICGC	LKENS	DEG_APCC_KENBOX_2	77:81	Mutation altering degron motif	0.6063
p.L77R	DO233866	GACA	ICGC	LKENS	DEG_APCC_KENBOX_2	77:81	Mutation altering degron motif	0.7316
p.V529L	DO228948	LICA	ICGC	LAPLVPPPTLLV	DEG_ODPH_VHL_1	514:525	Mutation rewiring degron network	0.2222
p.G68V	DO228976	LICA	ICGC	LKENS	DEG_APCC_KENBOX_2	77:81	Mutation rewiring degron network	0.0833
p.P504T	DO232224	PBCA	ICGC	LAPLVPPPTLLV	DEG_ODPH_VHL_1	514:525	Mutation rewiring degron network	0.0556
p.P534L	SIDM00789	Colorectal Carcinoma	GDSC	LAPLVPPPTLLV	DEG_ODPH_VHL_1	514:525	Mutation rewiring degron network	0.0833
p.P534L	ACH-000997	Colon/Colorectal Cancer	CCLE	LAPLVPPPTLLV	DEG_ODPH_VHL_1	514:525	Mutation rewiring degron network	0.0833
p.P534L	HCT-15	large intestine	COSMIC	LAPLVPPPTLLV	DEG_ODPH_VHL_1	514:525	Mutation rewiring degron network	0.0833
p.R71W	SIDM01779	Gastric Carcinoma	GDSC	LKENS	DEG_APCC_KENBOX_2	77:81	Mutation rewiring degron network	0.1667
p.R71W	ACH-000761	Gastric Cancer	CCLE	LKENS	DEG_APCC_KENBOX_2	77:81	Mutation rewiring degron network	0.1667

Kaplan plot for SOBP in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SOBP

UniProt ID: A7XYQ1

Entrez ID: 55084

Protein name: Sine oculis-binding protein homolog (Jackson circler protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SOBP in