DegronMD

Uniprot ID: A7XYQ1

Source protein: Sine oculis-binding protein homolog

Source gene: SOBP

Class: DEG_ODPH_VHL_1

Location: 514:525

E3 ligase: VHL

DEGRON score: 0.9778

ASA_SCORE: 82.0833

COIL: 0.9353

CONS_SCORE: 0.7059

DSS_SCORE: 0.0666

HELIX: 0.0168

FCONS_SCORE: 1.2099

RIG_SCORE: 0.7431

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A515V	TCGA-A5-A2K7	UCEC	TCGA	LAPLVPPPTLLV	DEG_ODPH_VHL_1	0.6936
p.A515V	TCGA-AP-A1DV	UCEC	TCGA	LAPLVPPPTLLV	DEG_ODPH_VHL_1	0.6936
p.A515V	DO43186	UCEC	ICGC	LAPLVPPPTLLV	DEG_ODPH_VHL_1	0.6936
p.A515V	DO41271	UCEC	ICGC	LAPLVPPPTLLV	DEG_ODPH_VHL_1	0.6936
p.P526S	TCGA-CG-4460	STAD	TCGA	LAPLVPPPTLLV	DEG_ODPH_VHL_1	0.3056
p.P526S	DO38427	STAD	ICGC	LAPLVPPPTLLV	DEG_ODPH_VHL_1	0.3056
p.P521S	TCGA-EE-A2MR	SKCM	TCGA	LAPLVPPPTLLV	DEG_ODPH_VHL_1	0.5641
p.P521S	DO37819	SKCM	ICGC	LAPLVPPPTLLV	DEG_ODPH_VHL_1	0.5641
p.V529L	DO228948	LICA	ICGC	LAPLVPPPTLLV	DEG_ODPH_VHL_1	0.2222
p.P504T	DO232224	PBCA	ICGC	LAPLVPPPTLLV	DEG_ODPH_VHL_1	0.0556
p.P534L	SIDM00789	Colorectal Carcinoma	GDSC	LAPLVPPPTLLV	DEG_ODPH_VHL_1	0.0833
p.P534L	ACH-000997	Colon/Colorectal Cancer	CCLE	LAPLVPPPTLLV	DEG_ODPH_VHL_1	0.0833
p.P534L	HCT-15	large_intestine	COSMIC	LAPLVPPPTLLV	DEG_ODPH_VHL_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A7XYQ1	Sine oculis-binding protein homolog	DEG_ODPH_VHL_1	514:525	LAPLVPPPTLLV	VHL	0.9778	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons