DegronMD - Q5THK1(PRR14L)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S616L	TCGA-A5-A0G1	UCEC	TCGA	DYR	CBL_MET	604:606	Mutation rewiring degron network	0.0556
p.S616L	DO42472	UCEC	ICGC	DYR	CBL_MET	604:606	Mutation rewiring degron network	0.0556
p.E610Q	DO44097	BLCA	ICGC	DYR	CBL_MET	604:606	Mutation rewiring degron network	0.2222
p.N339D	DO7801	COAD	ICGC	LKENS	DEG_APCC_KENBOX_2	336:340	Mutation altering degron motif	0.6932
p.T326K	DO229028	LICA	ICGC	LKENS	DEG_APCC_KENBOX_2	336:340	Mutation rewiring degron network	0.0556
p.A595D	DO229006	LICA	ICGC	DYR	CBL_MET	604:606	Mutation rewiring degron network	0.0833
p.E433V	DO38404	STAD	ICGC	PKENI	DEG_APCC_KENBOX_2	438:442	Mutation rewiring degron network	0.1944
p.H452R	SIDM00151	Ovarian Carcinoma	GDSC	PKENI	DEG_APCC_KENBOX_2	438:442	Mutation rewiring degron network	0.0556
p.H452R	ACH-000966	Ovarian Cancer	CCLE	PKENI	DEG_APCC_KENBOX_2	438:442	Mutation rewiring degron network	0.0556
p.H452R	IGROV-1	ovary	COSMIC	PKENI	DEG_APCC_KENBOX_2	438:442	Mutation rewiring degron network	0.0556
p.H452Y	SIDM00801	Melanoma	GDSC	PKENI	DEG_APCC_KENBOX_2	438:442	Mutation rewiring degron network	0.0556
p.H452Y	ACH-000008	Skin Cancer	CCLE	PKENI	DEG_APCC_KENBOX_2	438:442	Mutation rewiring degron network	0.0556
p.H452Y	A101D	skin	COSMIC	PKENI	DEG_APCC_KENBOX_2	438:442	Mutation rewiring degron network	0.0556
p.T331I	SIDM01133	Other Solid Cancers	GDSC	LKENS	DEG_APCC_KENBOX_2	336:340	Mutation rewiring degron network	0.1944
p.T331I	ACH-002177	Lung Cancer	CCLE	LKENS	DEG_APCC_KENBOX_2	336:340	Mutation rewiring degron network	0.1944
p.T331I	NCI-H835	lung	COSMIC	LKENS	DEG_APCC_KENBOX_2	336:340	Mutation rewiring degron network	0.1944
p.E341K	ACH-000554	Breast Cancer	CCLE	LKENS	DEG_APCC_KENBOX_2	336:340	Mutation rewiring degron network	0.3056

Kaplan plot for PRR14L in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PRR14L

UniProt ID: Q5THK1

Entrez ID: 253143

Protein name: Protein PRR14L (Proline rich 14-like protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PRR14L in