DegronMD

Uniprot ID: Q5THK1

Source protein: Protein PRR14L

Source gene: PRR14L

Class: DEG_APCC_KENBOX_2

Location: 438:442

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8839

ASA_SCORE: 107.38

COIL: 0.871

CONS_SCORE: 0.3359

DSS_SCORE: 0.5179

HELIX: 0.087

FCONS_SCORE: 0.9983

RIG_SCORE: 0.6831

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E433V	DO38404	STAD	ICGC	PKENI	DEG_APCC_KENBOX_2	0.1944
p.H452R	SIDM00151	Ovarian Carcinoma	GDSC	PKENI	DEG_APCC_KENBOX_2	0.0556
p.H452R	ACH-000966	Ovarian Cancer	CCLE	PKENI	DEG_APCC_KENBOX_2	0.0556
p.H452R	IGROV-1	ovary	COSMIC	PKENI	DEG_APCC_KENBOX_2	0.0556
p.H452Y	SIDM00801	Melanoma	GDSC	PKENI	DEG_APCC_KENBOX_2	0.0556
p.H452Y	ACH-000008	Skin Cancer	CCLE	PKENI	DEG_APCC_KENBOX_2	0.0556
p.H452Y	A101D	skin	COSMIC	PKENI	DEG_APCC_KENBOX_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P63151	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform	DEG_APCC_KENBOX_2	426:430	PKENI	APC,CDC20,FZR1	0.8287	More...
Q5JSH3	WD repeat-containing protein 44	DEG_APCC_KENBOX_2	277:281	PKENI	APC,CDC20,FZR1	0.7835	More...
Q5THK1	Protein PRR14L	DEG_APCC_KENBOX_2	438:442	PKENI	APC,CDC20,FZR1	0.8839	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons