DegronMD - Q5JSH3(WDR44)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L104M	TCGA-06-5416	GBM	TCGA	ARTDLSNIP	DEG_APCC_DBOX_1	100:108	Mutation altering degron motif	0.711
p.G365V	TCGA-44-7670	LUAD	TCGA	NLDTGE	DEG_Kelch_Keap1_1	361:366	Mutation altering degron motif	0.7532
p.S283C	TCGA-55-8302	LUAD	TCGA	PKENI	DEG_APCC_KENBOX_2	277:281	Mutation rewiring degron network	0.2778
p.S96R	TCGA-75-6211	LUAD	TCGA	ARTDLSNIP	DEG_APCC_DBOX_1	100:108	Mutation blocking phosphorylation signal	0.6667
p.D273H	TCGA-98-8022	LUSC	TCGA	PKENI	DEG_APCC_KENBOX_2	277:281	Mutation rewiring degron network	0.2222
p.M358I	TCGA-AJ-A5DW	UCEC	TCGA	NLDTGE	DEG_Kelch_Keap1_1	361:366	Mutation rewiring degron network	0.25
p.P97H	TCGA-B5-A0JY	UCEC	TCGA	ARTDLSNIP	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.25
p.L370F	TCGA-BA-5152	HNSC	TCGA	NLDTGE	DEG_Kelch_Keap1_1	361:366	Mutation rewiring degron network	0.2222
p.M291I	TCGA-D3-A2JD	SKCM	TCGA	PKENI	DEG_APCC_KENBOX_2	277:281	Mutation rewiring degron network	0.0556
p.D91Y	TCGA-EB-A24D	SKCM	TCGA	ARTDLSNIP	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.0833
p.P277S	TCGA-FR-A8YC	SKCM	TCGA	PKENI	DEG_APCC_KENBOX_2	277:281	Mutation altering degron motif	0.5641
p.P277S	SIDM01522	B-Lymphoblastic Leukemia	GDSC	PKENI	DEG_APCC_KENBOX_2	277:281	Mutation altering degron motif	0.5641
p.P277S	ACH-000080	Leukemia	CCLE	PKENI	DEG_APCC_KENBOX_2	277:281	Mutation altering degron motif	0.5641
p.D114E	TCGA-GL-7773	KIRP	TCGA	ARTDLSNIP	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.1667
p.S290G	TCGA-JX-A3Q0	CESC	TCGA	PKENI	DEG_APCC_KENBOX_2	277:281	Mutation blocking phosphorylation signal	0.5278
p.K270E	TCGA-KQ-A41N	BLCA	TCGA	PKENI	DEG_APCC_KENBOX_2	277:281	Mutation substituting flanking lysine	0.25
p.E279Q	TCGA-Q1-A73O	CESC	TCGA	PKENI	DEG_APCC_KENBOX_2	277:281	Mutation altering degron motif	0.6744
p.L112F	DO44037	BLCA	ICGC	ARTDLSNIP	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.2222
p.E269K	DO2755	BRCA	ICGC	PKENI	DEG_APCC_KENBOX_2	277:281	Mutation rewiring degron network	0.1111
p.E269K	DO224563	LUSC	ICGC	PKENI	DEG_APCC_KENBOX_2	277:281	Mutation rewiring degron network	0.1111
p.A375V	DO14582	HNSC	ICGC	NLDTGE	DEG_Kelch_Keap1_1	361:366	Mutation rewiring degron network	0.0833
p.S101T	DO49773	KIRP	ICGC	ARTDLSNIP	DEG_APCC_DBOX_1	100:108	Mutation altering degron motif	0.7116
p.Q102H	DO229026	LICA	ICGC	ARTDLSNIP	DEG_APCC_DBOX_1	100:108	Mutation altering degron motif	0.7582
p.C115R	DO46396	OV	ICGC	ARTDLSNIP	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.1389
p.A376T	DO219319	PRAD	ICGC	NLDTGE	DEG_Kelch_Keap1_1	361:366	Mutation substituting flanking lysine	0.1667
p.P358S	DO37881	SKCM	ICGC	NLDTGE	DEG_Kelch_Keap1_1	361:366	Mutation rewiring degron network	0.25
p.D280N	DO47623	SKCM	ICGC	PKENI	DEG_APCC_KENBOX_2	277:281	Mutation altering degron motif	0.6932
p.V91L	DO229213	THCA	ICGC	ARTDLSNIP	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.0833
p.R366M	DO43266	UCEC	ICGC	NLDTGE	DEG_Kelch_Keap1_1	361:366	Mutation altering degron motif	0.8632
p.P358H	DO41572	UCEC	ICGC	NLDTGE	DEG_Kelch_Keap1_1	361:366	Mutation rewiring degron network	0.25
p.S101N	DO41871	UCEC	ICGC	ARTDLSNIP	DEG_APCC_DBOX_1	100:108	Mutation altering degron motif	0.7069
p.K368N	DO43755	UCEC	ICGC	NLDTGE	DEG_Kelch_Keap1_1	361:366	Mutation rewiring degron network	0.2778
p.D288N	DO43755	UCEC	ICGC	PKENI	DEG_APCC_KENBOX_2	277:281	Mutation rewiring degron network	0.1389
p.S275Y	DO43971	UCEC	ICGC	PKENI	DEG_APCC_KENBOX_2	277:281	Mutation rewiring degron network	0.2778
p.I113M	SIDM01722	Non-Cancerous	GDSC	ARTDLSNIP	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.1944
p.I113M	SIDM00174	Head and Neck Carcinoma	GDSC	ARTDLSNIP	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.1944
p.G109R	SIDM00845	Burkitt's Lymphoma	GDSC	ARTDLSNIP	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.3056
p.G109R	ACH-000786	Lymphoma	CCLE	ARTDLSNIP	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.3056
p.G109R	Daudi	haematopoietic and lymphoid tissue	COSMIC	ARTDLSNIP	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.3056
p.D284A	SIDM00410	Other Blood Cancers	GDSC	PKENI	DEG_APCC_KENBOX_2	277:281	Mutation rewiring degron network	0.25
p.D284A	ACH-002317	Leukemia	CCLE	PKENI	DEG_APCC_KENBOX_2	277:281	Mutation rewiring degron network	0.25
p.D284A	YT	haematopoietic and lymphoid tissue	COSMIC	PKENI	DEG_APCC_KENBOX_2	277:281	Mutation rewiring degron network	0.25
p.S290R	SIDM00758	Non-Small Cell Lung Carcinoma	GDSC	PKENI	DEG_APCC_KENBOX_2	277:281	Mutation blocking phosphorylation signal	0.5278
p.S290R	SIDM00757	Non-Small Cell Lung Carcinoma	GDSC	PKENI	DEG_APCC_KENBOX_2	277:281	Mutation blocking phosphorylation signal	0.5278
p.S290R	ACH-000590	Lung Cancer	CCLE	PKENI	DEG_APCC_KENBOX_2	277:281	Mutation blocking phosphorylation signal	0.5278
p.S290R	ACH-001137	Lung Cancer	CCLE	PKENI	DEG_APCC_KENBOX_2	277:281	Mutation blocking phosphorylation signal	0.5278
p.S290R	NCI-H1993	lung	COSMIC	PKENI	DEG_APCC_KENBOX_2	277:281	Mutation blocking phosphorylation signal	0.5278
p.N280S	SIDM00121	T-Lymphoblastic Leukemia	GDSC	PKENI	DEG_APCC_KENBOX_2	277:281	Mutation altering degron motif	0.7069
p.N280S	ACH-001738	Leukemia	CCLE	PKENI	DEG_APCC_KENBOX_2	277:281	Mutation altering degron motif	0.7069
p.N280S	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	PKENI	DEG_APCC_KENBOX_2	277:281	Mutation altering degron motif	0.7069
p.S96C	SIDM00182	Head and Neck Carcinoma	GDSC	ARTDLSNIP	DEG_APCC_DBOX_1	100:108	Mutation blocking phosphorylation signal	0.6667
p.S96C	ACH-002265	Head and Neck Cancer	CCLE	ARTDLSNIP	DEG_APCC_DBOX_1	100:108	Mutation blocking phosphorylation signal	0.6667
p.S96C	LB771-HNC	upper aerodigestive tract	COSMIC	ARTDLSNIP	DEG_APCC_DBOX_1	100:108	Mutation blocking phosphorylation signal	0.6667
p.K278R	SIDM00930	Osteosarcoma	GDSC	PKENI	DEG_APCC_KENBOX_2	277:281	Mutation altering degron motif	0.7237
p.E352D	ACH-000993	Endometrial/Uterine Cancer	CCLE	NLDTGE	DEG_Kelch_Keap1_1	361:366	Mutation rewiring degron network	0.0833
p.S118F	HCC-827	lung	COSMIC	ARTDLSNIP	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.0556
p.A375T	REH	haematopoietic and lymphoid tissue	COSMIC	NLDTGE	DEG_Kelch_Keap1_1	361:366	Mutation rewiring degron network	0.0833
p.P117L	HCC-827	lung	COSMIC	ARTDLSNIP	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.0833
p.E94K	NCI-H835	lung	COSMIC	ARTDLSNIP	DEG_APCC_DBOX_1	100:108	Mutation blocking phosphorylation signal	0.6111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

WDR44

UniProt ID: Q5JSH3

Entrez ID: 54521

Protein name: WD repeat-containing protein 44 (Rabphilin-11)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for WDR44 in