DegronMD

Uniprot ID: Q5JSH3

Source protein: WD repeat-containing protein 44

Source gene: WDR44

Class: DEG_APCC_DBOX_1

Location: 100:108

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8126

ASA_SCORE: 70.1333

COIL: 0.6338

CONS_SCORE: 0.1728

DSS_SCORE: 0.3271

HELIX: 0.2567

FCONS_SCORE: 0.7561

RIG_SCORE: 0.762

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L104M	TCGA-06-5416	GBM	TCGA	ARTDLSNIP	DEG_APCC_DBOX_1	0.711
p.S96R	TCGA-75-6211	LUAD	TCGA	ARTDLSNIP	DEG_APCC_DBOX_1	0.6667
p.P97H	TCGA-B5-A0JY	UCEC	TCGA	ARTDLSNIP	DEG_APCC_DBOX_1	0.25
p.D91Y	TCGA-EB-A24D	SKCM	TCGA	ARTDLSNIP	DEG_APCC_DBOX_1	0.0833
p.D114E	TCGA-GL-7773	KIRP	TCGA	ARTDLSNIP	DEG_APCC_DBOX_1	0.1667
p.L112F	DO44037	BLCA	ICGC	ARTDLSNIP	DEG_APCC_DBOX_1	0.2222
p.S101T	DO49773	KIRP	ICGC	ARTDLSNIP	DEG_APCC_DBOX_1	0.7116
p.Q102H	DO229026	LICA	ICGC	ARTDLSNIP	DEG_APCC_DBOX_1	0.7582
p.C115R	DO46396	OV	ICGC	ARTDLSNIP	DEG_APCC_DBOX_1	0.1389
p.V91L	DO229213	THCA	ICGC	ARTDLSNIP	DEG_APCC_DBOX_1	0.0833
p.S101N	DO41871	UCEC	ICGC	ARTDLSNIP	DEG_APCC_DBOX_1	0.7069
p.I113M	SIDM01722	Non-Cancerous	GDSC	ARTDLSNIP	DEG_APCC_DBOX_1	0.1944
p.I113M	SIDM00174	Head and Neck Carcinoma	GDSC	ARTDLSNIP	DEG_APCC_DBOX_1	0.1944
p.G109R	SIDM00845	Burkitt's Lymphoma	GDSC	ARTDLSNIP	DEG_APCC_DBOX_1	0.3056
p.G109R	ACH-000786	Lymphoma	CCLE	ARTDLSNIP	DEG_APCC_DBOX_1	0.3056
p.G109R	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	ARTDLSNIP	DEG_APCC_DBOX_1	0.3056
p.S96C	SIDM00182	Head and Neck Carcinoma	GDSC	ARTDLSNIP	DEG_APCC_DBOX_1	0.6667
p.S96C	ACH-002265	Head and Neck Cancer	CCLE	ARTDLSNIP	DEG_APCC_DBOX_1	0.6667
p.S96C	LB771-HNC	upper_aerodigestive_tract	COSMIC	ARTDLSNIP	DEG_APCC_DBOX_1	0.6667
p.S118F	HCC-827	lung	COSMIC	ARTDLSNIP	DEG_APCC_DBOX_1	0.0556
p.P117L	HCC-827	lung	COSMIC	ARTDLSNIP	DEG_APCC_DBOX_1	0.0833
p.E94K	NCI-H835	lung	COSMIC	ARTDLSNIP	DEG_APCC_DBOX_1	0.6111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5JSH3	WD repeat-containing protein 44	DEG_APCC_DBOX_1	100:108	ARTDLSNIP	APC,CDC20,FZR1	0.8126	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons