DegronMD

Uniprot ID: Q5JSH3

Source protein: WD repeat-containing protein 44

Source gene: WDR44

Class: DEG_Kelch_Keap1_1

Location: 361:366

E3 ligase: KEAP1

DEGRON score: 0.9763

ASA_SCORE: 69.6

COIL: 0.8695

CONS_SCORE: 0.4209

DSS_SCORE: 0.3042

HELIX: 0.0132

FCONS_SCORE: 1.3465

RIG_SCORE: 0.7553

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G365V	TCGA-44-7670	LUAD	TCGA	NLDTGE	DEG_Kelch_Keap1_1	0.7532
p.M358I	TCGA-AJ-A5DW	UCEC	TCGA	NLDTGE	DEG_Kelch_Keap1_1	0.25
p.L370F	TCGA-BA-5152	HNSC	TCGA	NLDTGE	DEG_Kelch_Keap1_1	0.2222
p.A375V	DO14582	HNSC	ICGC	NLDTGE	DEG_Kelch_Keap1_1	0.0833
p.A376T	DO219319	PRAD	ICGC	NLDTGE	DEG_Kelch_Keap1_1	0.1667
p.P358S	DO37881	SKCM	ICGC	NLDTGE	DEG_Kelch_Keap1_1	0.25
p.R366M	DO43266	UCEC	ICGC	NLDTGE	DEG_Kelch_Keap1_1	0.8632
p.P358H	DO41572	UCEC	ICGC	NLDTGE	DEG_Kelch_Keap1_1	0.25
p.K368N	DO43755	UCEC	ICGC	NLDTGE	DEG_Kelch_Keap1_1	0.2778
p.E352D	ACH-000993	Endometrial/Uterine Cancer	CCLE	NLDTGE	DEG_Kelch_Keap1_1	0.0833
p.A375T	REH	haematopoietic_and_lymphoid_tissue	COSMIC	NLDTGE	DEG_Kelch_Keap1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5JSH3	WD repeat-containing protein 44	DEG_Kelch_Keap1_1	361:366	NLDTGE	KEAP1	0.9763	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons