DegronMD

Uniprot ID: Q5JSH3

Source protein: WD repeat-containing protein 44

Source gene: WDR44

Class: DEG_APCC_KENBOX_2

Location: 277:281

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7835

ASA_SCORE: 90.32

COIL: 0.8188

CONS_SCORE: 0.2449

DSS_SCORE: 0.5306

HELIX: 0.1204

FCONS_SCORE: 0.9378

RIG_SCORE: 0.7335

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S283C	TCGA-55-8302	LUAD	TCGA	PKENI	DEG_APCC_KENBOX_2	0.2778
p.D273H	TCGA-98-8022	LUSC	TCGA	PKENI	DEG_APCC_KENBOX_2	0.2222
p.M291I	TCGA-D3-A2JD	SKCM	TCGA	PKENI	DEG_APCC_KENBOX_2	0.0556
p.P277S	TCGA-FR-A8YC	SKCM	TCGA	PKENI	DEG_APCC_KENBOX_2	0.5641
p.P277S	SIDM01522	B-Lymphoblastic Leukemia	GDSC	PKENI	DEG_APCC_KENBOX_2	0.5641
p.P277S	ACH-000080	Leukemia	CCLE	PKENI	DEG_APCC_KENBOX_2	0.5641
p.S290G	TCGA-JX-A3Q0	CESC	TCGA	PKENI	DEG_APCC_KENBOX_2	0.5278
p.K270E	TCGA-KQ-A41N	BLCA	TCGA	PKENI	DEG_APCC_KENBOX_2	0.25
p.E279Q	TCGA-Q1-A73O	CESC	TCGA	PKENI	DEG_APCC_KENBOX_2	0.6744
p.E269K	DO2755	BRCA	ICGC	PKENI	DEG_APCC_KENBOX_2	0.1111
p.E269K	DO224563	LUSC	ICGC	PKENI	DEG_APCC_KENBOX_2	0.1111
p.D280N	DO47623	SKCM	ICGC	PKENI	DEG_APCC_KENBOX_2	0.6932
p.D288N	DO43755	UCEC	ICGC	PKENI	DEG_APCC_KENBOX_2	0.1389
p.S275Y	DO43971	UCEC	ICGC	PKENI	DEG_APCC_KENBOX_2	0.2778
p.D284A	SIDM00410	Other Blood Cancers	GDSC	PKENI	DEG_APCC_KENBOX_2	0.25
p.D284A	ACH-002317	Leukemia	CCLE	PKENI	DEG_APCC_KENBOX_2	0.25
p.D284A	YT	haematopoietic_and_lymphoid_tissue	COSMIC	PKENI	DEG_APCC_KENBOX_2	0.25
p.S290R	SIDM00758	Non-Small Cell Lung Carcinoma	GDSC	PKENI	DEG_APCC_KENBOX_2	0.5278
p.S290R	SIDM00757	Non-Small Cell Lung Carcinoma	GDSC	PKENI	DEG_APCC_KENBOX_2	0.5278
p.S290R	ACH-000590	Lung Cancer	CCLE	PKENI	DEG_APCC_KENBOX_2	0.5278
p.S290R	ACH-001137	Lung Cancer	CCLE	PKENI	DEG_APCC_KENBOX_2	0.5278
p.S290R	NCI-H1993	lung	COSMIC	PKENI	DEG_APCC_KENBOX_2	0.5278
p.N280S	SIDM00121	T-Lymphoblastic Leukemia	GDSC	PKENI	DEG_APCC_KENBOX_2	0.7069
p.N280S	ACH-001738	Leukemia	CCLE	PKENI	DEG_APCC_KENBOX_2	0.7069
p.N280S	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	PKENI	DEG_APCC_KENBOX_2	0.7069
p.K278R	SIDM00930	Osteosarcoma	GDSC	PKENI	DEG_APCC_KENBOX_2	0.7237

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P63151	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform	DEG_APCC_KENBOX_2	426:430	PKENI	APC,CDC20,FZR1	0.8287	More...
Q5JSH3	WD repeat-containing protein 44	DEG_APCC_KENBOX_2	277:281	PKENI	APC,CDC20,FZR1	0.7835	More...
Q5THK1	Protein PRR14L	DEG_APCC_KENBOX_2	438:442	PKENI	APC,CDC20,FZR1	0.8839	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PKENI

Degron related mutations and impact score

Drug responses associated with WDR44 mutations

All proteins holding degron of PKENI