DegronMD

Uniprot ID: P63151

Source protein: Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

Source gene: PPP2R2A

Class: DEG_APCC_KENBOX_2

Location: 426:430

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8287

ASA_SCORE: 62.92

COIL: 0.786

CONS_SCORE: 0.4938

DSS_SCORE: 0.1649

HELIX: 0.0096

FCONS_SCORE: 0.8788

RIG_SCORE: 0.8609

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A433V	TCGA-24-1552	OV	TCGA	PKENI	DEG_APCC_KENBOX_2	0.25
p.A433V	DO31551	OV	ICGC	PKENI	DEG_APCC_KENBOX_2	0.25
p.S419I	TCGA-A5-A0G2	UCEC	TCGA	PKENI	DEG_APCC_KENBOX_2	0.1389
p.S419I	DO41235	UCEC	ICGC	PKENI	DEG_APCC_KENBOX_2	0.1389
p.K427T	TCGA-CA-6717	COAD	TCGA	PKENI	DEG_APCC_KENBOX_2	0.7306
p.K427T	DO8264	COAD	ICGC	PKENI	DEG_APCC_KENBOX_2	0.7306
p.D424H	TCGA-DX-AB2W	SARC	TCGA	PKENI	DEG_APCC_KENBOX_2	0.2778
p.D424H	DO220095	SARC	ICGC	PKENI	DEG_APCC_KENBOX_2	0.2778
p.A433S	DO229019	LICA	ICGC	PKENI	DEG_APCC_KENBOX_2	0.25
p.V433I	ACH-001669	Leukemia	CCLE	PKENI	DEG_APCC_KENBOX_2	0.25
p.V433I	ACH-002238	Leukemia	CCLE	PKENI	DEG_APCC_KENBOX_2	0.25
p.V433I	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	PKENI	DEG_APCC_KENBOX_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P63151	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform	DEG_APCC_KENBOX_2	426:430	PKENI	APC,CDC20,FZR1	0.8287	More...
Q5JSH3	WD repeat-containing protein 44	DEG_APCC_KENBOX_2	277:281	PKENI	APC,CDC20,FZR1	0.7835	More...
Q5THK1	Protein PRR14L	DEG_APCC_KENBOX_2	438:442	PKENI	APC,CDC20,FZR1	0.8839	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons