DegronMD

Uniprot ID: Q9H1H9

Source protein: Kinesin-like protein KIF13A

Source gene: KIF13A

Class: DEG_SPOP_SBC_1

Location: 519:523

E3 ligase: SPOP

DEGRON score: 0.6481

ASA_SCORE: 54.04

COIL: 0.4248

CONS_SCORE: 0.4012

DSS_SCORE: 0.0909

HELIX: 0.0024

FCONS_SCORE: 0.6973

RIG_SCORE: 0.8694

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T517I	TCGA-21-1079	LUSC	TCGA	VCSTT	DEG_SPOP_SBC_1	0.2778
p.T517I	DO26846	LUSC	ICGC	VCSTT	DEG_SPOP_SBC_1	0.2778
p.L525M	TCGA-A5-A1OF	UCEC	TCGA	VCSTT	DEG_SPOP_SBC_1	0.2778
p.L525M	DO42568	UCEC	ICGC	VCSTT	DEG_SPOP_SBC_1	0.2778
p.H527N	DO229037	LICA	ICGC	VCSTT	DEG_SPOP_SBC_1	0.2222
p.R530Q	TCGA-A5-A2K5	UCEC	TCGA	VCSTT	DEG_SPOP_SBC_1	0.1389
p.R530Q	TCGA-AA-A00N	COAD	TCGA	VCSTT	DEG_SPOP_SBC_1	0.1389
p.R530Q	DO9876	COAD	ICGC	VCSTT	DEG_SPOP_SBC_1	0.1389
p.R530Q	DO41379	UCEC	ICGC	VCSTT	DEG_SPOP_SBC_1	0.1389
p.L532P	TCGA-06-0649	GBM	TCGA	VCSTT	DEG_SPOP_SBC_1	0.0833
p.L532P	DO11142	GBM	ICGC	VCSTT	DEG_SPOP_SBC_1	0.0833

Showing 1 to 11 of 11 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H1H9	Kinesin-like protein KIF13A	DEG_SPOP_SBC_1	519:523	VCSTT	SPOP	0.6481	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons