DegronMD

Uniprot ID: Q9H1H9

Source protein: Kinesin-like protein KIF13A

Source gene: KIF13A

Class: DEG_SPOP_SBC_1

Location: 1590:1594

E3 ligase: SPOP

DEGRON score: 0.9958

ASA_SCORE: 71.92

COIL: 0.8218

CONS_SCORE: 0.338

DSS_SCORE: 0.3949

HELIX: 0.0466

FCONS_SCORE: 1.0941

RIG_SCORE: 0.6552

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1598C	TCGA-AA-A02O	COAD	TCGA	PTTSS	DEG_SPOP_SBC_1	0.2222
p.R1588H	TCGA-BW-A5NP	LIHC	TCGA	PTTSS	DEG_SPOP_SBC_1	0.2778
p.R1588H	TCGA-GR-A4D9	DLBC	TCGA	PTTSS	DEG_SPOP_SBC_1	0.2778
p.R1588L	TCGA-CV-6962	HNSC	TCGA	PTTSS	DEG_SPOP_SBC_1	0.2778
p.R1588S	TCGA-GN-A265	SKCM	TCGA	PTTSS	DEG_SPOP_SBC_1	0.2778
p.Q1591K	DO229015	LICA	ICGC	PTTSS	DEG_SPOP_SBC_1	0.6944
p.H1600N	DO229045	LICA	ICGC	PTTSS	DEG_SPOP_SBC_1	0.1667
p.S1581C	DO24830	LUAD	ICGC	PTTSS	DEG_SPOP_SBC_1	0.0833
p.T1592M	DO232761	PBCA	ICGC	PTTSS	DEG_SPOP_SBC_1	0.7423
p.S1585L	DO37896	SKCM	ICGC	PTTSS	DEG_SPOP_SBC_1	0.1944
p.D1586N	DO50284	SKCM	ICGC	PTTSS	DEG_SPOP_SBC_1	0.2222
p.S1604L	DO43306	UCEC	ICGC	PTTSS	DEG_SPOP_SBC_1	0.0556
p.R1588C	SIDM01154	T-Lymphoblastic Leukemia	GDSC	PTTSS	DEG_SPOP_SBC_1	0.2778
p.R1588C	ACH-000953	Leukemia	CCLE	PTTSS	DEG_SPOP_SBC_1	0.2778
p.R1588C	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	PTTSS	DEG_SPOP_SBC_1	0.2778
p.S1599F	NCI-H847	lung	COSMIC	PTTSS	DEG_SPOP_SBC_1	0.1944
p.D1594E	COLO-741	large_intestine	COSMIC	PTTSS	DEG_SPOP_SBC_1	0.6758
p.D1581E	COLO-741	large_intestine	COSMIC	PTTSS	DEG_SPOP_SBC_1	0.0833
p.S1600L	NCI-H847	lung	COSMIC	PTTSS	DEG_SPOP_SBC_1	0.1667
p.D1581H	NCI-H2342	lung	COSMIC	PTTSS	DEG_SPOP_SBC_1	0.0833
p.D1594H	NCI-H2342	lung	COSMIC	PTTSS	DEG_SPOP_SBC_1	0.7688
p.L1604S	SNU-1040	large_intestine	COSMIC	PTTSS	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14776	Transcription elongation regulator 1	DEG_SPOP_SBC_1	261:265	PTTSS	SPOP	0.9948	More...
O15054	Lysine-specific demethylase 6B	DEG_SPOP_SBC_1	549:553	PTTSS	SPOP	0.8155	More...
O60336	Mitogen-activated protein kinase-binding protein 1	DEG_SPOP_SBC_1	1250:1254	PTTSS	SPOP	0.9955	More...
P35869	Aryl hydrocarbon receptor	DEG_SPOP_SBC_1	730:734	PTTSS	SPOP	0.9973	More...
P55055	Oxysterols receptor LXR-beta	DEG_SPOP_SBC_1	4:8	PTTSS	SPOP	0.9972	More...
Q12955	Ankyrin-3	DEG_SPOP_SBC_1	2207:2211	PTTSS	SPOP	0.9961	More...
Q15915	Zinc finger protein ZIC 1	DEG_SPOP_SBC_1	417:421	PTTSS	SPOP	0.9909	More...
Q7Z7G0	Target of Nesh-SH3	DEG_SPOP_SBC_1	341:345	PTTSS	SPOP	0.992	More...
Q8IZF0	Sodium leak channel NALCN	DEG_SPOP_SBC_1	682:686	PTTSS	SPOP	0.8231	More...
Q8N0V3	Putative ribosome-binding factor A, mitochondrial	DEG_SPOP_SBC_1	230:234	PTTSS	SPOP	0.9938	More...
Q8N7W2	BEN domain-containing protein 7	DEG_SPOP_SBC_1	144:148	PTTSS	SPOP	0.6957	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	6756:6760	PTTSS	SPOP	0.7898	More...
Q9BRK4	Leucine zipper putative tumor suppressor 2	DEG_SPOP_SBC_1	238:242	PTTSS	SPOP	0.9196	More...
Q9H1H9	Kinesin-like protein KIF13A	DEG_SPOP_SBC_1	1590:1594	PTTSS	SPOP	0.9958	More...
Q9H254	Spectrin beta chain, non-erythrocytic 4	DEG_SPOP_SBC_1	2540:2544	PTTSS	SPOP	0.9961	More...
Q9Y5J3	Hairy/enhancer-of-split related with YRPW motif protein 1	DEG_SPOP_SBC_1	41:45	PTTSS	SPOP	0.6104	More...
Q9H3M9	Ataxin-3-like protein	DEG_SPOP_SBC_1	314:318	PTTSS	SPOP	0.999	More...
O75333	T-box transcription factor TBX10	DEG_SPOP_SBC_1	21:25	PTTSS	SPOP	0.988	More...
Q5JXX7	Transmembrane protein 31	DEG_SPOP_SBC_1	60:64	PTTSS	SPOP	0.5118	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTTSS

Degron related mutations and impact score

Drug responses associated with KIF13A mutations

All proteins holding degron of PTTSS