DegronMD - Q12955(ANK3)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T3583M	TCGA-06-0154	GBM	TCGA	PATTPDTT	DEG_SCF_FBW7_1	3576:3583	Mutation altering degron motif	0.7423
p.T3583M	TCGA-IG-A3I8	ESCA	TCGA	PATTPDTT	DEG_SCF_FBW7_1	3576:3583	Mutation altering degron motif	0.7423
p.T3583M	DO12292	GBM	ICGC	PATTPDTT	DEG_SCF_FBW7_1	3576:3583	Mutation altering degron motif	0.7423
p.T3583M	DO32817	PACA	ICGC	PATTPDTT	DEG_SCF_FBW7_1	3576:3583	Mutation altering degron motif	0.7423
p.T3583M	SIDM01135	Pancreatic Carcinoma	GDSC	PATTPDTT	DEG_SCF_FBW7_1	3576:3583	Mutation altering degron motif	0.7423
p.T3583M	ACH-000060	Pancreatic Cancer	CCLE	PATTPDTT	DEG_SCF_FBW7_1	3576:3583	Mutation altering degron motif	0.7423
p.T3583M	PANC-10-05	pancreas	COSMIC	PATTPDTT	DEG_SCF_FBW7_1	3576:3583	Mutation altering degron motif	0.7423
p.F2200Y	TCGA-21-1079	LUSC	TCGA	PTTSS	DEG_SPOP_SBC_1	2207:2211	Mutation rewiring degron network	0.1389
p.F2200Y	DO26846	LUSC	ICGC	PTTSS	DEG_SPOP_SBC_1	2207:2211	Mutation rewiring degron network	0.1389
p.E4347Q	TCGA-56-7822	LUSC	TCGA	LSLHEE	LIG_APCC_ABBA_1	4341:4346	Mutation rewiring degron network	0.3056
p.E4347Q	TCGA-56-7822	LUSC	TCGA	RLSLHEE	LIG_APCC_ABBAyCdc20_2	4340:4346	Mutation rewiring degron network	0.3056
p.E4347Q	DO26638	LUSC	ICGC	LSLHEE	LIG_APCC_ABBA_1	4341:4346	Mutation rewiring degron network	0.3056
p.E4347Q	DO26638	LUSC	ICGC	RLSLHEE	LIG_APCC_ABBAyCdc20_2	4340:4346	Mutation rewiring degron network	0.3056
p.S1563F	TCGA-A5-A0G2	UCEC	TCGA	ASTTS	DEG_SPOP_SBC_1	1555:1559	Mutation rewiring degron network	0.2222
p.S1563F	DO222908	MELA	ICGC	ASTTS	DEG_SPOP_SBC_1	1555:1559	Mutation rewiring degron network	0.2222
p.S1563F	DO41235	UCEC	ICGC	ASTTS	DEG_SPOP_SBC_1	1555:1559	Mutation rewiring degron network	0.2222
p.T3587M	TCGA-A5-A0VP	UCEC	TCGA	PARTPTDE	DEG_SCF_FBW7_2	3584:3591	Mutation altering degron motif	0.7423
p.T3587M	DO50786	LICA	ICGC	PARTPTDE	DEG_SCF_FBW7_2	3584:3591	Mutation altering degron motif	0.7423
p.T3587M	DO42600	UCEC	ICGC	PARTPTDE	DEG_SCF_FBW7_2	3584:3591	Mutation altering degron motif	0.7423
p.S4333Y	TCGA-AA-A010	COAD	TCGA	LSLHEE	LIG_APCC_ABBA_1	4341:4346	Mutation blocking phosphorylation signal	0.5556
p.S4333Y	TCGA-AA-A010	COAD	TCGA	RLSLHEE	LIG_APCC_ABBAyCdc20_2	4340:4346	Mutation blocking phosphorylation signal	0.5833
p.T2199N	TCGA-AG-3892	READ	TCGA	PTTSS	DEG_SPOP_SBC_1	2207:2211	Mutation rewiring degron network	0.1111
p.T2199N	DO36394	READ	ICGC	PTTSS	DEG_SPOP_SBC_1	2207:2211	Mutation rewiring degron network	0.1111
p.T1738N	TCGA-AJ-A3EK	UCEC	TCGA	PSSST	DEG_SPOP_SBC_1	1726:1730	Mutation rewiring degron network	0.1111
p.T1738N	DO41584	UCEC	ICGC	PSSST	DEG_SPOP_SBC_1	1726:1730	Mutation rewiring degron network	0.1111
p.F1387C	TCGA-AJ-A5DW	UCEC	TCGA	FKENR	DEG_APCC_KENBOX_2	1390:1394	Mutation rewiring degron network	0.25
p.A1608V	TCGA-AX-A1CE	UCEC	TCGA	VTEATPLK	DEG_SCF_SKP2-CKS1_1	1605:1612	Mutation altering degron motif	0.5825
p.A1608V	DO42280	UCEC	ICGC	VTEATPLK	DEG_SCF_SKP2-CKS1_1	1605:1612	Mutation altering degron motif	0.5825
p.D3590G	TCGA-B5-A11E	UCEC	TCGA	PARTPTDE	DEG_SCF_FBW7_2	3584:3591	Mutation altering degron motif	0.6087
p.D3590G	DO41644	UCEC	ICGC	PARTPTDE	DEG_SCF_FBW7_2	3584:3591	Mutation altering degron motif	0.6087
p.T1619M	TCGA-B5-A11E	UCEC	TCGA	VTEATPLK	DEG_SCF_SKP2-CKS1_1	1605:1612	Mutation rewiring degron network	0.1389
p.T1619M	DO35597	PBCA	ICGC	VTEATPLK	DEG_SCF_SKP2-CKS1_1	1605:1612	Mutation rewiring degron network	0.1389
p.T1619M	DO41644	UCEC	ICGC	VTEATPLK	DEG_SCF_SKP2-CKS1_1	1605:1612	Mutation rewiring degron network	0.1389
p.E3180G	TCGA-B5-A1MX	UCEC	TCGA	PETPSSE	DEG_SCF_FBW7_2	3169:3175	Mutation rewiring degron network	0.1944
p.E3180G	DO41999	UCEC	ICGC	PETPSSE	DEG_SCF_FBW7_2	3169:3175	Mutation rewiring degron network	0.1944
p.P3169L	TCGA-B5-A1MX	UCEC	TCGA	PETPSSE	DEG_SCF_FBW7_2	3169:3175	Mutation altering degron motif	0.6471
p.P3169L	DO41999	UCEC	ICGC	PETPSSE	DEG_SCF_FBW7_2	3169:3175	Mutation altering degron motif	0.6471
p.S3165N	TCGA-BB-7870	HNSC	TCGA	PETPSSE	DEG_SCF_FBW7_2	3169:3175	Mutation rewiring degron network	0.2222
p.S3165N	DO14378	HNSC	ICGC	PETPSSE	DEG_SCF_FBW7_2	3169:3175	Mutation rewiring degron network	0.2222
p.E2632Q	TCGA-BH-A0HP	BRCA	TCGA	PTSSS	DEG_SPOP_SBC_1	2626:2630	Mutation rewiring degron network	0.2778
p.E2632Q	TCGA-FD-A5C1	BLCA	TCGA	PTSSS	DEG_SPOP_SBC_1	2626:2630	Mutation rewiring degron network	0.2778
p.E2632Q	DO44043	BLCA	ICGC	PTSSS	DEG_SPOP_SBC_1	2626:2630	Mutation rewiring degron network	0.2778
p.E2632Q	DO1755	BRCA	ICGC	PTSSS	DEG_SPOP_SBC_1	2626:2630	Mutation rewiring degron network	0.2778
p.E3572Q	TCGA-BH-A1EV	BRCA	TCGA	PATTPDTT	DEG_SCF_FBW7_1	3576:3583	Mutation rewiring degron network	0.2222
p.E3572Q	DO1797	BRCA	ICGC	PATTPDTT	DEG_SCF_FBW7_1	3576:3583	Mutation rewiring degron network	0.2222
p.T3666A	TCGA-BQ-7048	KIRP	TCGA	VETPTVE	DEG_SCF_FBW7_2	3675:3681	Mutation rewiring degron network	0.0833
p.T3666A	DO20936	KIRP	ICGC	VETPTVE	DEG_SCF_FBW7_2	3675:3681	Mutation rewiring degron network	0.0833
p.T1606M	TCGA-BR-4201	STAD	TCGA	VTEATPLK	DEG_SCF_SKP2-CKS1_1	1605:1612	Mutation altering degron motif	0.6312
p.T1606M	TCGA-L5-A8NM	ESCA	TCGA	VTEATPLK	DEG_SCF_SKP2-CKS1_1	1605:1612	Mutation altering degron motif	0.6312
p.T1606M	DO38707	STAD	ICGC	VTEATPLK	DEG_SCF_SKP2-CKS1_1	1605:1612	Mutation altering degron motif	0.6312
p.T3903A	TCGA-CK-4951	COAD	TCGA	ALTTS	DEG_SPOP_SBC_1	3900:3904	Mutation altering degron motif	0.7139
p.T3903A	DO10582	COAD	ICGC	ALTTS	DEG_SPOP_SBC_1	3900:3904	Mutation altering degron motif	0.7139
p.C3906S	TCGA-CQ-7071	HNSC	TCGA	ALTTS	DEG_SPOP_SBC_1	3900:3904	Mutation rewiring degron network	0.2778
p.C3906S	DO49069	HNSC	ICGC	ALTTS	DEG_SPOP_SBC_1	3900:3904	Mutation rewiring degron network	0.2778
p.S1721F	TCGA-D3-A2JF	SKCM	TCGA	PSSST	DEG_SPOP_SBC_1	1726:1730	Mutation rewiring degron network	0.1944
p.S1721F	TCGA-EE-A2MS	SKCM	TCGA	PSSST	DEG_SPOP_SBC_1	1726:1730	Mutation rewiring degron network	0.1944
p.S1721F	TCGA-YG-AA3N	SKCM	TCGA	PSSST	DEG_SPOP_SBC_1	1726:1730	Mutation rewiring degron network	0.1944
p.S1721F	DO222868	MELA	ICGC	PSSST	DEG_SPOP_SBC_1	1726:1730	Mutation rewiring degron network	0.1944
p.S1721F	DO37567	SKCM	ICGC	PSSST	DEG_SPOP_SBC_1	1726:1730	Mutation rewiring degron network	0.1944
p.S1721F	DO51298	SKCM	ICGC	PSSST	DEG_SPOP_SBC_1	1726:1730	Mutation rewiring degron network	0.1944
p.S1721F	DO38153	SKCM	ICGC	PSSST	DEG_SPOP_SBC_1	1726:1730	Mutation rewiring degron network	0.1944
p.E1635D	TCGA-D3-A3CE	SKCM	TCGA	ITMTPPAS	DEG_SCF_FBW7_1	1639:1646	Mutation rewiring degron network	0.2222
p.E1635D	DO37405	SKCM	ICGC	ITMTPPAS	DEG_SCF_FBW7_1	1639:1646	Mutation rewiring degron network	0.2222
p.P3678L	TCGA-D3-A3MV	SKCM	TCGA	VETPTVE	DEG_SCF_FBW7_2	3675:3681	Mutation altering degron motif	0.7582
p.P3678L	DO37727	SKCM	ICGC	VETPTVE	DEG_SCF_FBW7_2	3675:3681	Mutation altering degron motif	0.7582
p.P1644L	TCGA-D3-A8GI	SKCM	TCGA	ITMTPPAS	DEG_SCF_FBW7_1	1639:1646	Mutation altering degron motif	0.6471
p.P1644L	DO50284	SKCM	ICGC	ITMTPPAS	DEG_SCF_FBW7_1	1639:1646	Mutation altering degron motif	0.6471
p.P1644S	TCGA-D3-A8GI	SKCM	TCGA	ITMTPPAS	DEG_SCF_FBW7_1	1639:1646	Mutation altering degron motif	0.5641
p.P1644S	DO50284	SKCM	ICGC	ITMTPPAS	DEG_SCF_FBW7_1	1639:1646	Mutation altering degron motif	0.5641
p.P2205T	TCGA-DX-A6YR	SARC	TCGA	PTTSS	DEG_SPOP_SBC_1	2207:2211	Mutation rewiring degron network	0.2778
p.P2205T	DO220003	SARC	ICGC	PTTSS	DEG_SPOP_SBC_1	2207:2211	Mutation rewiring degron network	0.2778
p.D4336N	TCGA-EE-A182	SKCM	TCGA	LSLHEE	LIG_APCC_ABBA_1	4341:4346	Mutation rewiring degron network	0.1944
p.D4336N	TCGA-EE-A182	SKCM	TCGA	RLSLHEE	LIG_APCC_ABBAyCdc20_2	4340:4346	Mutation rewiring degron network	0.2222
p.S1728F	TCGA-EE-A183	SKCM	TCGA	PSSST	DEG_SPOP_SBC_1	1726:1730	Mutation altering degron motif	0.7982
p.S1728F	DO37715	SKCM	ICGC	PSSST	DEG_SPOP_SBC_1	1726:1730	Mutation altering degron motif	0.7982
p.S1551F	TCGA-EE-A29D	SKCM	TCGA	ASTTS	DEG_SPOP_SBC_1	1555:1559	Mutation blocking phosphorylation signal	0.6667
p.S1551F	DO38123	SKCM	ICGC	ASTTS	DEG_SPOP_SBC_1	1555:1559	Mutation blocking phosphorylation signal	0.6667
p.E3572D	TCGA-EE-A2A2	SKCM	TCGA	PATTPDTT	DEG_SCF_FBW7_1	3576:3583	Mutation rewiring degron network	0.2222
p.E3572D	DO37583	SKCM	ICGC	PATTPDTT	DEG_SCF_FBW7_1	3576:3583	Mutation rewiring degron network	0.2222
p.T3582I	TCGA-EE-A3AB	SKCM	TCGA	PATTPDTT	DEG_SCF_FBW7_1	3576:3583	Mutation altering degron motif	0.5966
p.T3582I	DO222670	MELA	ICGC	PATTPDTT	DEG_SCF_FBW7_1	3576:3583	Mutation altering degron motif	0.5966
p.T3582I	DO38057	SKCM	ICGC	PATTPDTT	DEG_SCF_FBW7_1	3576:3583	Mutation altering degron motif	0.5966
p.P1726L	TCGA-EE-A3AE	SKCM	TCGA	PSSST	DEG_SPOP_SBC_1	1726:1730	Mutation altering degron motif	0.7582
p.P1726L	DO37802	SKCM	ICGC	PSSST	DEG_SPOP_SBC_1	1726:1730	Mutation altering degron motif	0.7582
p.R4340K	TCGA-ER-A19A	SKCM	TCGA	RLSLHEE	LIG_APCC_ABBAyCdc20_2	4340:4346	Mutation altering degron motif	0.6126
p.P3580T	TCGA-ER-A19G	SKCM	TCGA	PATTPDTT	DEG_SCF_FBW7_1	3576:3583	Mutation altering degron motif	0.7031
p.P3580T	DO47284	SKCM	ICGC	PATTPDTT	DEG_SCF_FBW7_1	3576:3583	Mutation altering degron motif	0.7031
p.H4344N	TCGA-F7-A624	HNSC	TCGA	LSLHEE	LIG_APCC_ABBA_1	4341:4346	Mutation altering degron motif	0.7423
p.H4344N	TCGA-F7-A624	HNSC	TCGA	RLSLHEE	LIG_APCC_ABBAyCdc20_2	4340:4346	Mutation altering degron motif	0.7423
p.A1568T	TCGA-FI-A2EU	UCEC	TCGA	ASTTS	DEG_SPOP_SBC_1	1555:1559	Mutation rewiring degron network	0.0833
p.A1568T	DO42865	UCEC	ICGC	ASTTS	DEG_SPOP_SBC_1	1555:1559	Mutation rewiring degron network	0.0833
p.E2202K	TCGA-FR-A3YN	SKCM	TCGA	PTTSS	DEG_SPOP_SBC_1	2207:2211	Mutation rewiring degron network	0.1944
p.E2202K	DO38111	SKCM	ICGC	PTTSS	DEG_SPOP_SBC_1	2207:2211	Mutation rewiring degron network	0.1944
p.K4355E	TCGA-FR-A44A	SKCM	TCGA	LSLHEE	LIG_APCC_ABBA_1	4341:4346	Mutation substituting flanking lysine	0.1944
p.K4355E	TCGA-FR-A44A	SKCM	TCGA	RLSLHEE	LIG_APCC_ABBAyCdc20_2	4340:4346	Mutation substituting flanking lysine	0.1944
p.G3163E	TCGA-FR-A7U9	SKCM	TCGA	PETPSSE	DEG_SCF_FBW7_2	3169:3175	Mutation rewiring degron network	0.1667
p.G3163E	DO48546	SKCM	ICGC	PETPSSE	DEG_SCF_FBW7_2	3169:3175	Mutation rewiring degron network	0.1667
p.S1621F	TCGA-FS-A1ZK	SKCM	TCGA	VTEATPLK	DEG_SCF_SKP2-CKS1_1	1605:1612	Mutation rewiring degron network	0.0833
p.S1621F	DO222710	MELA	ICGC	VTEATPLK	DEG_SCF_SKP2-CKS1_1	1605:1612	Mutation rewiring degron network	0.0833
p.S1621F	DO218840	SKCA	ICGC	VTEATPLK	DEG_SCF_SKP2-CKS1_1	1605:1612	Mutation rewiring degron network	0.0833
p.S1621F	DO37474	SKCM	ICGC	VTEATPLK	DEG_SCF_SKP2-CKS1_1	1605:1612	Mutation rewiring degron network	0.0833
p.P2205L	TCGA-FW-A3R5	SKCM	TCGA	PTTSS	DEG_SPOP_SBC_1	2207:2211	Mutation rewiring degron network	0.2778
p.P2205L	DO37406	SKCM	ICGC	PTTSS	DEG_SPOP_SBC_1	2207:2211	Mutation rewiring degron network	0.2778
p.R1394K	TCGA-FW-A3R5	SKCM	TCGA	FKENR	DEG_APCC_KENBOX_2	1390:1394	Mutation altering degron motif	0.6126
p.E3676Q	TCGA-G2-A2EJ	BLCA	TCGA	VETPTVE	DEG_SCF_FBW7_2	3675:3681	Mutation altering degron motif	0.5633
p.E3676Q	DO554	BLCA	ICGC	VETPTVE	DEG_SCF_FBW7_2	3675:3681	Mutation altering degron motif	0.5633
p.P3914A	TCGA-GM-A2D9	BRCA	TCGA	ALTTS	DEG_SPOP_SBC_1	3900:3904	Mutation rewiring degron network	0.0556
p.P3914A	DO4810	BRCA	ICGC	ALTTS	DEG_SPOP_SBC_1	3900:3904	Mutation rewiring degron network	0.0556
p.P3576L	TCGA-GN-A4U4	SKCM	TCGA	PATTPDTT	DEG_SCF_FBW7_1	3576:3583	Mutation altering degron motif	0.6471
p.P3576L	DO51256	SKCM	ICGC	PATTPDTT	DEG_SCF_FBW7_1	3576:3583	Mutation altering degron motif	0.6471
p.R541Q	TCGA-GN-A4U7	SKCM	TCGA	AATTS	DEG_SPOP_SBC_1	527:531	Mutation rewiring degron network	0.0556
p.T1609M	TCGA-HT-8011	LGG	TCGA	VTEATPLK	DEG_SCF_SKP2-CKS1_1	1605:1612	Mutation altering degron motif	0.7423
p.T1609M	DO22197	LGG	ICGC	VTEATPLK	DEG_SCF_SKP2-CKS1_1	1605:1612	Mutation altering degron motif	0.7423
p.S1649L	TCGA-RP-A695	SKCM	TCGA	ITMTPPAS	DEG_SCF_FBW7_1	1639:1646	Mutation rewiring degron network	0.25
p.S1649L	DO51270	SKCM	ICGC	ITMTPPAS	DEG_SCF_FBW7_1	1639:1646	Mutation rewiring degron network	0.25
p.T3582A	TCGA-T3-A92N	HNSC	TCGA	PATTPDTT	DEG_SCF_FBW7_1	3576:3583	Mutation altering degron motif	0.6028
p.T3582A	DO219073	HNSC	ICGC	PATTPDTT	DEG_SCF_FBW7_1	3576:3583	Mutation altering degron motif	0.6028
p.K2619E	TCGA-VQ-A8PZ	STAD	TCGA	PTSSS	DEG_SPOP_SBC_1	2626:2630	Mutation substituting flanking lysine	0.25
p.K2619E	DO51780	STAD	ICGC	PTSSS	DEG_SPOP_SBC_1	2626:2630	Mutation substituting flanking lysine	0.25
p.E1607K	TCGA-WE-AAA3	SKCM	TCGA	VTEATPLK	DEG_SCF_SKP2-CKS1_1	1605:1612	Mutation altering degron motif	0.7022
p.E1607K	DO51295	SKCM	ICGC	VTEATPLK	DEG_SCF_SKP2-CKS1_1	1605:1612	Mutation altering degron motif	0.7022
p.E3591K	TCGA-XF-AAN2	BLCA	TCGA	PARTPTDE	DEG_SCF_FBW7_2	3584:3591	Mutation altering degron motif	0.7022
p.E3591K	DO219052	BLCA	ICGC	PARTPTDE	DEG_SCF_FBW7_2	3584:3591	Mutation altering degron motif	0.7022
p.G522V	TCGA-YD-A89C	SKCM	TCGA	AATTS	DEG_SPOP_SBC_1	527:531	Mutation rewiring degron network	0.1944
p.G538A	DO219098	BLCA	ICGC	AATTS	DEG_SPOP_SBC_1	527:531	Mutation rewiring degron network	0.1389
p.V530M	DO225281	BRCA	ICGC	AATTS	DEG_SPOP_SBC_1	527:531	Mutation altering degron motif	0.7208
p.D1726H	DO1755	BRCA	ICGC	PSSST	DEG_SPOP_SBC_1	1726:1730	Mutation altering degron motif	0.7688
p.D1719N	DO2204	BRCA	ICGC	PSSST	DEG_SPOP_SBC_1	1726:1730	Mutation rewiring degron network	0.1389
p.P3951A	DO229363	BTCA	ICGC	VTTTT	DEG_SPOP_SBC_1	3959:3963	Mutation rewiring degron network	0.1111
p.L1546F	DO219722	CESC	ICGC	ASTTS	DEG_SPOP_SBC_1	1555:1559	Mutation rewiring degron network	0.0833
p.D1613G	DO7783	COAD	ICGC	VTEATPLK	DEG_SCF_SKP2-CKS1_1	1605:1612	Mutation rewiring degron network	0.3056
p.P1610S	DO228935	COCA	ICGC	VTEATPLK	DEG_SCF_SKP2-CKS1_1	1605:1612	Mutation altering degron motif	0.6752
p.S1720I	DO227549	COCA	ICGC	PSSST	DEG_SPOP_SBC_1	1726:1730	Mutation rewiring degron network	0.1667
p.T3898P	DO227802	COCA	ICGC	ALTTS	DEG_SPOP_SBC_1	3900:3904	Mutation rewiring degron network	0.2778
p.A1645V	DO227802	COCA	ICGC	ITMTPPAS	DEG_SCF_FBW7_1	1639:1646	Mutation altering degron motif	0.5825
p.A1645V	DO23132	LINC	ICGC	ITMTPPAS	DEG_SCF_FBW7_1	1639:1646	Mutation altering degron motif	0.5825
p.S2622F	DO222762	COCA	ICGC	PTSSS	DEG_SPOP_SBC_1	2626:2630	Mutation rewiring degron network	0.2222
p.F1391L	DO228745	EOPC	ICGC	FKENR	DEG_APCC_KENBOX_2	1390:1394	Mutation altering degron motif	0.6981
p.S1619A	DO50450	ESAD	ICGC	VTEATPLK	DEG_SCF_SKP2-CKS1_1	1605:1612	Mutation rewiring degron network	0.1389
p.A1555T	DO233888	GACA	ICGC	ASTTS	DEG_SPOP_SBC_1	1555:1559	Mutation altering degron motif	0.7139
p.S1645Y	DO14307	HNSC	ICGC	ITMTPPAS	DEG_SCF_FBW7_1	1639:1646	Mutation altering degron motif	0.712
p.A532V	DO51816	LGG	ICGC	AATTS	DEG_SPOP_SBC_1	527:531	Mutation rewiring degron network	0.3056
p.A532V	DO229213	THCA	ICGC	AATTS	DEG_SPOP_SBC_1	527:531	Mutation rewiring degron network	0.3056
p.A532V	DO42713	UCEC	ICGC	AATTS	DEG_SPOP_SBC_1	527:531	Mutation rewiring degron network	0.3056
p.E3668D	DO228947	LICA	ICGC	VETPTVE	DEG_SCF_FBW7_2	3675:3681	Mutation rewiring degron network	0.1389
p.F533L	DO228974	LICA	ICGC	AATTS	DEG_SPOP_SBC_1	527:531	Mutation blocking phosphorylation signal	0.7222
p.S2630R	DO228974	LICA	ICGC	PTSSS	DEG_SPOP_SBC_1	2626:2630	Mutation altering degron motif	0.7427
p.T1598N	DO228971	LICA	ICGC	VTEATPLK	DEG_SCF_SKP2-CKS1_1	1605:1612	Mutation rewiring degron network	0.1389
p.T1598N	DO229019	LICA	ICGC	VTEATPLK	DEG_SCF_SKP2-CKS1_1	1605:1612	Mutation rewiring degron network	0.1389
p.T3903N	DO228986	LICA	ICGC	ALTTS	DEG_SPOP_SBC_1	3900:3904	Mutation altering degron motif	0.7055
p.P1643T	DO232033	LICA	ICGC	ITMTPPAS	DEG_SCF_FBW7_1	1639:1646	Mutation altering degron motif	0.7031
p.H527N	DO229032	LICA	ICGC	AATTS	DEG_SPOP_SBC_1	527:531	Mutation altering degron motif	0.7423
p.V3909L	DO50790	LICA	ICGC	ALTTS	DEG_SPOP_SBC_1	3900:3904	Mutation rewiring degron network	0.1944
p.V3907I	DO228898	LICA	ICGC	ALTTS	DEG_SPOP_SBC_1	3900:3904	Mutation rewiring degron network	0.25
p.A1645S	DO45083	LINC	ICGC	ITMTPPAS	DEG_SCF_FBW7_1	1639:1646	Mutation altering degron motif	0.6477
p.R3586K	DO23518	LIRI	ICGC	PARTPTDE	DEG_SCF_FBW7_2	3584:3591	Mutation altering degron motif	0.6126
p.I1562V	DO45312	LUAD	ICGC	ASTTS	DEG_SPOP_SBC_1	1555:1559	Mutation substituting flanking lysine	0.3611
p.E3896K	DO230942	LUSC	ICGC	ALTTS	DEG_SPOP_SBC_1	3900:3904	Mutation rewiring degron network	0.2222
p.E3896K	SIDM01664	Prostate Carcinoma	GDSC	ALTTS	DEG_SPOP_SBC_1	3900:3904	Mutation rewiring degron network	0.2222
p.E3896K	ACH-000952	Prostate Cancer	CCLE	ALTTS	DEG_SPOP_SBC_1	3900:3904	Mutation rewiring degron network	0.2222
p.T1653N	DO224539	LUSC	ICGC	ITMTPPAS	DEG_SCF_FBW7_1	1639:1646	Mutation rewiring degron network	0.1389
p.T1653N	DO231010	LUSC	ICGC	ITMTPPAS	DEG_SCF_FBW7_1	1639:1646	Mutation rewiring degron network	0.1389
p.T3578R	DO231114	LUSC	ICGC	PATTPDTT	DEG_SCF_FBW7_1	3576:3583	Mutation altering degron motif	0.6765
p.A523T	DO52654	MALY	ICGC	AATTS	DEG_SPOP_SBC_1	527:531	Mutation rewiring degron network	0.2222
p.S1595F	DO220877	MELA	ICGC	VTEATPLK	DEG_SCF_SKP2-CKS1_1	1605:1612	Mutation rewiring degron network	0.0556
p.M1641I	DO220882	MELA	ICGC	ITMTPPAS	DEG_SCF_FBW7_1	1639:1646	Mutation altering degron motif	0.6507
p.P1650L	DO220886	MELA	ICGC	ITMTPPAS	DEG_SCF_FBW7_1	1639:1646	Mutation rewiring degron network	0.2222
p.M2221I	DO220890	MELA	ICGC	PTTSS	DEG_SPOP_SBC_1	2207:2211	Mutation rewiring degron network	0.0556
p.G1634R	DO220903	MELA	ICGC	ITMTPPAS	DEG_SCF_FBW7_1	1639:1646	Mutation rewiring degron network	0.1944
p.P3914S	DO222595	MELA	ICGC	ALTTS	DEG_SPOP_SBC_1	3900:3904	Mutation rewiring degron network	0.0556
p.D1613N	DO222578	MELA	ICGC	VTEATPLK	DEG_SCF_SKP2-CKS1_1	1605:1612	Mutation rewiring degron network	0.3056
p.D1633N	DO222632	MELA	ICGC	ITMTPPAS	DEG_SCF_FBW7_1	1639:1646	Mutation rewiring degron network	0.1667
p.D529N	DO222702	MELA	ICGC	AATTS	DEG_SPOP_SBC_1	527:531	Mutation altering degron motif	0.6932
p.D1613Y	DO222708	MELA	ICGC	VTEATPLK	DEG_SCF_SKP2-CKS1_1	1605:1612	Mutation rewiring degron network	0.3056
p.G1380R	DO232761	PBCA	ICGC	FKENR	DEG_APCC_KENBOX_2	1390:1394	Mutation rewiring degron network	0.0556
p.G1380R	DO229459	SKCA	ICGC	FKENR	DEG_APCC_KENBOX_2	1390:1394	Mutation rewiring degron network	0.0556
p.V3959I	DO232224	PBCA	ICGC	VTTTT	DEG_SPOP_SBC_1	3959:3963	Mutation altering degron motif	0.7076
p.A532E	DO220314	SARC	ICGC	AATTS	DEG_SPOP_SBC_1	527:531	Mutation rewiring degron network	0.3056
p.L1633F	DO229446	SKCA	ICGC	ITMTPPAS	DEG_SCF_FBW7_1	1639:1646	Mutation rewiring degron network	0.1667
p.P1721H	DO37835	SKCM	ICGC	PSSST	DEG_SPOP_SBC_1	1726:1730	Mutation rewiring degron network	0.1944
p.P1637L	DO37406	SKCM	ICGC	ITMTPPAS	DEG_SCF_FBW7_1	1639:1646	Mutation rewiring degron network	0.2778
p.R1395K	DO37406	SKCM	ICGC	FKENR	DEG_APCC_KENBOX_2	1390:1394	Mutation rewiring degron network	0.3056
p.E1740K	DO50297	SKCM	ICGC	PSSST	DEG_SPOP_SBC_1	1726:1730	Mutation rewiring degron network	0.0556
p.R524Q	DO51258	SKCM	ICGC	AATTS	DEG_SPOP_SBC_1	527:531	Mutation blocking phosphorylation signal	0.6944
p.V1652I	DO51784	STAD	ICGC	ITMTPPAS	DEG_SCF_FBW7_1	1639:1646	Mutation rewiring degron network	0.1667
p.V1652I	SIDM00429	B-Lymphoblastic Leukemia	GDSC	ITMTPPAS	DEG_SCF_FBW7_1	1639:1646	Mutation rewiring degron network	0.1667
p.V1652I	NALM-6	haematopoietic and lymphoid tissue	COSMIC	ITMTPPAS	DEG_SCF_FBW7_1	1639:1646	Mutation rewiring degron network	0.1667
p.V1545F	DO229272	THCA	ICGC	ASTTS	DEG_SPOP_SBC_1	1555:1559	Mutation rewiring degron network	0.0556
p.F1388C	DO50075	UCEC	ICGC	FKENR	DEG_APCC_KENBOX_2	1390:1394	Mutation rewiring degron network	0.2778
p.A539V	DO41644	UCEC	ICGC	AATTS	DEG_SPOP_SBC_1	527:531	Mutation blocking phosphorylation signal	0.5556
p.T1729A	DO41644	UCEC	ICGC	PSSST	DEG_SPOP_SBC_1	1726:1730	Mutation altering degron motif	0.7139
p.L1725I	DO41572	UCEC	ICGC	PSSST	DEG_SPOP_SBC_1	1726:1730	Mutation rewiring degron network	0.3056
p.D1718Y	DO43971	UCEC	ICGC	PSSST	DEG_SPOP_SBC_1	1726:1730	Mutation rewiring degron network	0.1111
p.R1636K	SIDM01151	Hepatocellular Carcinoma	GDSC	ITMTPPAS	DEG_SCF_FBW7_1	1639:1646	Mutation rewiring degron network	0.25
p.R1636K	SIDM00237	Non-Small Cell Lung Carcinoma	GDSC	ITMTPPAS	DEG_SCF_FBW7_1	1639:1646	Mutation rewiring degron network	0.25
p.R1636K	SIDM01029	Esophageal Squamous Cell Carcinoma	GDSC	ITMTPPAS	DEG_SCF_FBW7_1	1639:1646	Mutation rewiring degron network	0.25
p.C3958R	SIDM00845	Burkitt's Lymphoma	GDSC	VTTTT	DEG_SPOP_SBC_1	3959:3963	Mutation rewiring degron network	0.3056
p.C3958R	SIDM00461	Acute Myeloid Leukemia	GDSC	VTTTT	DEG_SPOP_SBC_1	3959:3963	Mutation rewiring degron network	0.3056
p.T3679A	SIDM01090	Colorectal Carcinoma	GDSC	VETPTVE	DEG_SCF_FBW7_2	3675:3681	Mutation altering degron motif	0.6028
p.T3679A	ACH-000943	Colon/Colorectal Cancer	CCLE	VETPTVE	DEG_SCF_FBW7_2	3675:3681	Mutation altering degron motif	0.6028
p.T3679A	RKO	large intestine	COSMIC	VETPTVE	DEG_SCF_FBW7_2	3675:3681	Mutation altering degron motif	0.6028
p.A1630V	SIDM00454	Rhabdomyosarcoma	GDSC	ITMTPPAS	DEG_SCF_FBW7_1	1639:1646	Mutation rewiring degron network	0.0833
p.T1740M	SIDM00525	Osteosarcoma	GDSC	PSSST	DEG_SPOP_SBC_1	1726:1730	Mutation rewiring degron network	0.0556
p.T1740M	SIDM00217	Colorectal Carcinoma	GDSC	PSSST	DEG_SPOP_SBC_1	1726:1730	Mutation rewiring degron network	0.0556
p.T1740M	ACH-000359	Bone Cancer	CCLE	PSSST	DEG_SPOP_SBC_1	1726:1730	Mutation rewiring degron network	0.0556
p.T1740M	ACH-000999	Colon/Colorectal Cancer	CCLE	PSSST	DEG_SPOP_SBC_1	1726:1730	Mutation rewiring degron network	0.0556
p.T1740M	SNU-1040	large intestine	COSMIC	PSSST	DEG_SPOP_SBC_1	1726:1730	Mutation rewiring degron network	0.0556
p.T1740M	MG-63	bone	COSMIC	PSSST	DEG_SPOP_SBC_1	1726:1730	Mutation rewiring degron network	0.0556
p.E3175D	SIDM00789	Colorectal Carcinoma	GDSC	PETPSSE	DEG_SCF_FBW7_2	3169:3175	Mutation altering degron motif	0.6758
p.E3175D	ACH-000997	Colon/Colorectal Cancer	CCLE	PETPSSE	DEG_SCF_FBW7_2	3169:3175	Mutation altering degron motif	0.6758
p.E3175D	HCT-15	large intestine	COSMIC	PETPSSE	DEG_SCF_FBW7_2	3169:3175	Mutation altering degron motif	0.6758
p.P3584S	SIDM01060	Melanoma	GDSC	PARTPTDE	DEG_SCF_FBW7_2	3584:3591	Mutation altering degron motif	0.6752
p.P3584S	ACH-000882	Skin Cancer	CCLE	PARTPTDE	DEG_SCF_FBW7_2	3584:3591	Mutation altering degron motif	0.6752
p.P3584S	IGR-1	skin	COSMIC	PARTPTDE	DEG_SCF_FBW7_2	3584:3591	Mutation altering degron motif	0.6752
p.Q2624E	SIDM00963	Breast Carcinoma	GDSC	PTSSS	DEG_SPOP_SBC_1	2626:2630	Mutation rewiring degron network	0.2778
p.Q2624E	ACH-000927	Breast Cancer	CCLE	PTSSS	DEG_SPOP_SBC_1	2626:2630	Mutation rewiring degron network	0.2778
p.Q2624E	BT-474	breast	COSMIC	PTSSS	DEG_SPOP_SBC_1	2626:2630	Mutation rewiring degron network	0.2778
p.S1619C	SIDM00375	Head and Neck Carcinoma	GDSC	VTEATPLK	DEG_SCF_SKP2-CKS1_1	1605:1612	Mutation rewiring degron network	0.1389
p.S1619C	SIDM00240	Cervical Carcinoma	GDSC	VTEATPLK	DEG_SCF_SKP2-CKS1_1	1605:1612	Mutation rewiring degron network	0.1389
p.S1619C	SIDM00381	Cervical Carcinoma	GDSC	VTEATPLK	DEG_SCF_SKP2-CKS1_1	1605:1612	Mutation rewiring degron network	0.1389
p.S1619C	SIDM01622	Breast Carcinoma	GDSC	VTEATPLK	DEG_SCF_SKP2-CKS1_1	1605:1612	Mutation rewiring degron network	0.1389
p.S1619C	SIDM01446	Glioblastoma	GDSC	VTEATPLK	DEG_SCF_SKP2-CKS1_1	1605:1612	Mutation rewiring degron network	0.1389
p.S1619C	SKG-IIIa	cervix	COSMIC	VTEATPLK	DEG_SCF_SKP2-CKS1_1	1605:1612	Mutation rewiring degron network	0.1389
p.S1619C	OMC-1	cervix	COSMIC	VTEATPLK	DEG_SCF_SKP2-CKS1_1	1605:1612	Mutation rewiring degron network	0.1389
p.S1619C	SKN-3	upper aerodigestive tract	COSMIC	VTEATPLK	DEG_SCF_SKP2-CKS1_1	1605:1612	Mutation rewiring degron network	0.1389
p.S539F	SIDM00006	Other Solid Cancers	GDSC	AATTS	DEG_SPOP_SBC_1	527:531	Mutation blocking phosphorylation signal	0.5556
p.S539F	ACH-001552	Skin Cancer	CCLE	AATTS	DEG_SPOP_SBC_1	527:531	Mutation blocking phosphorylation signal	0.5556
p.S539F	MCC26	skin	COSMIC	AATTS	DEG_SPOP_SBC_1	527:531	Mutation blocking phosphorylation signal	0.5556
p.R3574H	SIDM00431	T-Lymphoblastic Leukemia	GDSC	PATTPDTT	DEG_SCF_FBW7_1	3576:3583	Mutation rewiring degron network	0.2778
p.R3574H	SIDM00431	T-Lymphoblastic Leukemia	GDSC	PARTPTDE	DEG_SCF_FBW7_2	3584:3591	Mutation rewiring degron network	0.0556
p.R3574H	ACH-000918	Leukemia	CCLE	PATTPDTT	DEG_SCF_FBW7_1	3576:3583	Mutation rewiring degron network	0.2778
p.R3574H	ACH-000918	Leukemia	CCLE	PARTPTDE	DEG_SCF_FBW7_2	3584:3591	Mutation rewiring degron network	0.0556
p.R3574H	MOLT-16	haematopoietic and lymphoid tissue	COSMIC	PATTPDTT	DEG_SCF_FBW7_1	3576:3583	Mutation rewiring degron network	0.2778
p.R3574H	MOLT-16	haematopoietic and lymphoid tissue	COSMIC	PARTPTDE	DEG_SCF_FBW7_2	3584:3591	Mutation rewiring degron network	0.0556
p.F1620L	SIDM00118	Colorectal Carcinoma	GDSC	VTEATPLK	DEG_SCF_SKP2-CKS1_1	1605:1612	Mutation rewiring degron network	0.1111
p.F1620L	ACH-001081	Colon/Colorectal Cancer	CCLE	VTEATPLK	DEG_SCF_SKP2-CKS1_1	1605:1612	Mutation rewiring degron network	0.1111
p.F1620L	HCC2998	large intestine	COSMIC	VTEATPLK	DEG_SCF_SKP2-CKS1_1	1605:1612	Mutation rewiring degron network	0.1111
p.E2620K	SIDM01150	Non-Small Cell Lung Carcinoma	GDSC	PTSSS	DEG_SPOP_SBC_1	2626:2630	Mutation rewiring degron network	0.1667
p.E2620K	ACH-000416	Lung Cancer	CCLE	PTSSS	DEG_SPOP_SBC_1	2626:2630	Mutation rewiring degron network	0.1667
p.E2620K	NCI-H838	lung	COSMIC	PTSSS	DEG_SPOP_SBC_1	2626:2630	Mutation rewiring degron network	0.1667
p.N1733D	SIDM01608	Endometrial Carcinoma	GDSC	PSSST	DEG_SPOP_SBC_1	1726:1730	Mutation rewiring degron network	0.25
p.N1733D	ACH-000990	Endometrial/Uterine Cancer	CCLE	PSSST	DEG_SPOP_SBC_1	1726:1730	Mutation rewiring degron network	0.25
p.L3950W	SIDM01588	Endometrial Carcinoma	GDSC	VTTTT	DEG_SPOP_SBC_1	3959:3963	Mutation rewiring degron network	0.0833
p.S3905P	ACH-001991	Primary	CCLE	ALTTS	DEG_SPOP_SBC_1	3900:3904	Mutation rewiring degron network	0.3056
p.P3678S	ACH-002396	Bone Cancer	CCLE	VETPTVE	DEG_SCF_FBW7_2	3675:3681	Mutation altering degron motif	0.6752
p.P3678S	Sarc9371	bone	COSMIC	VETPTVE	DEG_SCF_FBW7_2	3675:3681	Mutation altering degron motif	0.6752
p.S1637L	ACH-002508	Skin Cancer	CCLE	ITMTPPAS	DEG_SCF_FBW7_1	1639:1646	Mutation rewiring degron network	0.2778
p.V1645I	NALM-6	haematopoietic and lymphoid tissue	COSMIC	ITMTPPAS	DEG_SCF_FBW7_1	1639:1646	Mutation altering degron motif	0.7076
p.S1651F	M14	skin	COSMIC	ITMTPPAS	DEG_SCF_FBW7_1	1639:1646	Mutation rewiring degron network	0.1944
p.S1612C	OMC-1	cervix	COSMIC	VTEATPLK	DEG_SCF_SKP2-CKS1_1	1605:1612	Mutation altering degron motif	0.7541
p.S1612C	SKN-3	upper aerodigestive tract	COSMIC	VTEATPLK	DEG_SCF_SKP2-CKS1_1	1605:1612	Mutation altering degron motif	0.7541
p.S1612C	SKG-IIIa	cervix	COSMIC	VTEATPLK	DEG_SCF_SKP2-CKS1_1	1605:1612	Mutation altering degron motif	0.7541
p.S533F	MCC26	skin	COSMIC	AATTS	DEG_SPOP_SBC_1	527:531	Mutation blocking phosphorylation signal	0.7222
p.G538R	Mewo	skin	COSMIC	AATTS	DEG_SPOP_SBC_1	527:531	Mutation rewiring degron network	0.1389
p.S1569L	DU-145	prostate	COSMIC	ASTTS	DEG_SPOP_SBC_1	1555:1559	Mutation rewiring degron network	0.0556
p.A532T	C-33-A	cervix	COSMIC	AATTS	DEG_SPOP_SBC_1	527:531	Mutation rewiring degron network	0.3056
p.L534F	COLO-792	skin	COSMIC	AATTS	DEG_SPOP_SBC_1	527:531	Mutation blocking phosphorylation signal	0.6944
p.S522F	MCC26	skin	COSMIC	AATTS	DEG_SPOP_SBC_1	527:531	Mutation rewiring degron network	0.1944
p.S1562L	DU-145	prostate	COSMIC	ASTTS	DEG_SPOP_SBC_1	1555:1559	Mutation substituting flanking lysine	0.3611

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ANK3

UniProt ID: Q12955

Entrez ID: 288

Protein name: Ankyrin-3 (ANK-3) (Ankyrin-G)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ANK3 in