DegronMD

Uniprot ID: Q12955

Source protein: Ankyrin-3

Source gene: ANK3

Class: LIG_APCC_ABBA_1

Location: 4341:4346

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9463

ASA_SCORE: 95.15

COIL: 0.723

CONS_SCORE: 0.2498

DSS_SCORE: 0.7365

HELIX: 0.065

FCONS_SCORE: 1.0583

RIG_SCORE: 0.6311

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E4347Q	TCGA-56-7822	LUSC	TCGA	LSLHEE	LIG_APCC_ABBA_1	0.3056
p.E4347Q	DO26638	LUSC	ICGC	LSLHEE	LIG_APCC_ABBA_1	0.3056
p.S4333Y	TCGA-AA-A010	COAD	TCGA	LSLHEE	LIG_APCC_ABBA_1	0.5556
p.D4336N	TCGA-EE-A182	SKCM	TCGA	LSLHEE	LIG_APCC_ABBA_1	0.1944
p.H4344N	TCGA-F7-A624	HNSC	TCGA	LSLHEE	LIG_APCC_ABBA_1	0.7423
p.K4355E	TCGA-FR-A44A	SKCM	TCGA	LSLHEE	LIG_APCC_ABBA_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12955	Ankyrin-3	LIG_APCC_ABBA_1	4341:4346	LSLHEE	APC,CDC20,FZR1	0.9463	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons